Abstract
Animal models of psychiatric conditions such as anxiety and depression attempt to represent some aspect of the etiology, symptomatology, or treatment of these disorders, in order to facilitate their scientific study (Treit, 1994; Mineka, 1985; Marks, 1987; Willner, 1994). Within this broad context, animal models of anxiolytic or antidepressant drug action can be viewed as treatment models concerned with the pharmacological control of human anxiety and depression. Animal models of anxiety, for example, have been particularly useful in the preclmical testing of benzodiazepme-type anxiolytics, in studying the functional relevance of the GABAA-benzodiazepine receptor system, and in characterizing the effects of benzodiazepine antagonists (e.g., Ro 15–1788 [flumazeml]), partial agonists (e.g., CGS 98961, and inverse agonists (e.g., B-CCM). For reviews see Thlebot (1983); La1 and Emmett-Oglesby (1983); File (1984;1985;1987); Crawley (1985); Treit (1985a;1994); Shephard (1986); Gardner (1988); Thiebot et al. (1988); and Lister (1990).
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References
Abe, M, Tabata, R, Saito, K, Matsuda, T, Baba, A, and Egawa, M (1996) Novel benzodioxan derivative, 5-[3-[((2S)-l, 4-benzodioxan-2-ylmethyl)-amino]propoxy]-l, 3-benzodioxole HCL (MKC-242), with anxiolytic-hke and antidepressant-like effects in animal models J Pharmacol Exp Ther 278, 898–905
Abel, E L and Hannigan, J H (1994) The immobility response in the forced swim test paradoxical effect of lmipramine Eur J Pharmacol 258, 261–264
Ad Sitsen, J M and Montgomery, S A (1994) The pharmacological treatment of depression and its problems, in Handbook of Depression and Anxiety A Biological Approach (den Boer J A. and Ad Sitsen J M, eds), Marcel Dekker, New York, pp 349–377
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, (DSM-IV™) 4th ed American Psychiatric Association, Washington, DC
Amsman, H, Remington, G, and Sklar, L S (1979) Effect of inescapable shock on subsequent escape performance catecholaminergic and cholinergic mediation of response initiation and maintenance Psychopharmacol 61, 107–124
Baizman E R, Eznn, A M, Ferrari, R. A, and Luttinger, D (1987) Pharmacologic profile of fezolamine fumarate a nontricyclic antidepressant in animal models. J Pharmacol Exp Ther 243, 40–54
Baldwin, H A, Johnston, A. L, and File, S E (1989) Antagonistic effects of caffeine and yohimbine in animal tests of anxiety. Eur. J Pharmacol 159, 211–215
Barrett, J E, Witkin, J M, Mansbach, R S., Skolnick, P., and Weissman, B A (1986) Behavioral studies with anxiolytic drugs. III. Antrpunishment actions of buspirone in the pigeon do not involve benodiazepine receptor mechanisms J Pharmacol Exp Ther 238, 1009–1013
Baudrie, V, De Vry, J, Broqua, P, Schmidt, B, Chaouloff, F, and Glaser, T (1993) Subchronic treatment with anxiolytic doses of the 5-HT1A receptor agonist 1psapirone does not affect 5-HT2 receptor sensitivity in the rat Eur J Pharmacol 231, 395–406
Beardslee, S L., Papadakis, E. Fontana, D J, and Commissans, R L (1990) Antipanic drug treatments’ failure to exert anxiolytic-hke effects on defensive burying behavior Pharmacol. Biochem Behav 35, 451–455
Benton, D and Nastiti, K. (1988) The influence of psychotropic drugs on the ultrasonic calling of mouse pups Psychopharmacol 95, 99–102
Benvenga, M J and Leander, J D (1993) Antidepressant-hke effect of LY228729 as measured in the rodent forced swim paradigm Eur J Pharmacol 239, 249–252
Besson, A, Pnvat, A M, Eschaher, A, and Fialip, J. (1996) Effects of morphine, naloxone and their interaction in the learned helplessness paradigm Psychopharmacol 123, 71–78
Blampied, N M and Kirk, R C (1983) Defensive burying effects of diazepam and oxprenolol measured in extinction Life Sci 33, 695–699
Blumstein, L. K and Crawley, J N (1983) Further characterization of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines Pharmacol Biochem Behav 18, 37–40
Borsini, F (1995) Role of the serotonergic system in the forced swimming test Neurosci Biobehav Rev 19, 377–395
Borsini, F., Evangelista, S, and Meli, A (1986) Effect of GABAergic drugs in the behavioural ‘despair’ test in rats Eur J Pharmacol 121, 265–268
Borison, R. L, Albrecht, J W, and Diamond, B. I (1990) Efficacy and safety of a putative anxyiolytic agent: ipsapirone Psychopharmacol Bull 26, 207–210
Brocco, M J., Koek, W, Degryse, A D., and Colpaert, F. C (1990) Comparative studies on the anti-punishment effects of chlordiazepoxide, buspirone and ritanserin in the pigeon, Geller-Seifter and Vogel conflict procedures Behav Pharmacol 1, 403–418
Broekkamp, C. L, Garngou, D, and Lloyd, K G (1980) Serotonin-mimetic and antidepressant drugs on passive avoidance learning by olfactory bulb ectomized rats Pharmacol Biochem Behav 13, 643–646
Broekkamp, C L., Rijk, H W., Joly-Gelouin, D, and Lloyd, K L (1986) Major tranquilizers can be distinguished from minor tranquilizers on the basis of effects on marble burying and swim-induced grooming in mice Eur. J Pharmacol 126, 223–229
Brown, J. S, Kahsh, H I., and Farber, I E. (1951) Conditioned fear as revealed by magnitude of startle response to an auditory stimulus J Exp Psychol 41, 317–328
Browne, R G. (1979) Effects of antidepressants and anticholinergics in a mouse “behavioral despair” test Eur J Pharmacol 58, 331–334
Buckett, W R and Luscombe, G P (1985) Anomolous “depressant” activity of trazodone and related halogenated phenylpipenzines in a putative model of depression Br J Pharmacol 86, 590P.
Burkard, W P, Bonetti, E P, Da Prada, M, Martin, J R, Pole, P, Schaffner, R, Scherschhcht, R, Hefti, F, Muller, R K, Wyss, P C, and Haefely, W (1989) Pharmacological profile of moclobemide, a short-acting and reversible inhibitor of monamine oxidase type A J Pharmacol Exp Ther 248, 391–399
Cadogan, A K, Wright, I K, Coombs, I, Marsden, C A, Kendall, D A, and Tulloch, I (1992) Repeated paxroxetine administration in the rat produces an anxiolytic profile in the elevated X-maze and decreased [3H]-ketansenn binding Neurosci Lett 42(Suppl) S8
Caille, D., Bergis, O. E., Fankhauser, C, Gardes, A., Adam, R., Chaneras, T, Grosset, A, Rovei, V, and Jarreau, F X. (1996) Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor 11 Pharmacological profile. J Pharmacol Exp Ther 277, 265–277
Cairncross, K D, Cox, B, Forster, C, and Wren, A T (1979) Olfactory pro jection systems, drugs and behaviour a review Pyschoneuroendocrmol 4, 253–272
Cairncross, K D, Schofield, S P M, and Bassett, J R (1975) Endogenous brain norepinephrine levels following bilateral olfactory bulb ablation Pharmacol Biochem Behav 3, 425–427
Cairncross, K D, Wren, A F., Cox, B, and Schnieden, H (1977) Effects of olfac tory bulbectomy and domicile on stress induced corticosterone release in the rat. Physiol Behav 19, 485–487
Cannizzaro, G, Flugy, A, Cannizzaro, C, Gaghano, M, and Sabatino, M (1993) Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetet razol Eur Neuropsychopharmacol 3, 477–484
Carden, S E, and Hofer, M A (1990) Independence of benzodiazepine and opiate action in the suppression of isolation distress in rat pups Behav Neurosci 104, 160–166
Carh, M., Prontera, C, and Samanin, R (1989) Evidence that central 5-hydroxytryptaminergic neurons are involved in the anxiolytic activity of buspirone Br.J Pharmacol 96, 829–836
Cassella, J V. and Davis, M (1985) Fear-enhanced acoustic startle is not attenu ated by acute or chronic lmipramine treatment in rats Psychopharmacol 87, 278–282.
Cervo, L, Gngnaschi, G, Rossi, C, and Samanin, R (1991) Role of central sero tonergic neurons in the effect of sertraline in rats in the forced swimming test Eur J Pharmacol 196, 217–222
Cheeta, S, Broekkamp, C, and Willner, P (1994) Stereospecific reversal of stress-induced anhedonia by mianserin and its (+)-enantiomer Psychopharmacol 116, 523–528.
Chojnacka-Wojcik, E, Tatarczynska, E, Golembiowska, K, and Przegahnski, E (1991) Involvement of 5-HT1A receptors in the antidepressant-hke ac tivity of gepirone in the forced swimming test in rats Neuropharmacol 30, 711–717
Christensen, A V and Geoffroy, M (1991) The effect of different serotonergic drugs in the learned helplessness model of depression Animal Models Psychopharmacol 205–209
Cole, J. C, Burroughs, G. J., Laverty, C. R., Sheriff, N C, Sparham, E A, and Rodgers, R J. (1995) Anxiolytic-hke effects of yohimbine in the murine plus-maze strain independence and evidence against alpha 2-adrenoceptor mediation. Psychopharmacol 118, 425–436
Cole, J C and Rodgers, R J (1994) Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test com parison with halopendol Psychopharmacol 114, 288–296
Cole, J C and Rodgers, R J (1995) Ethological comparison of the effects of diazepam and acute/chronic lmipramine on the behaviour of mice in the elevated plus-maze Pharmacol Biochem Behav 52, 473–478
Commissaris, R L and Fontana, D J. (1991) Pharmacological evaluation of potential animal models for the study of antipanic and panicogenic treat ment effects, in Animal Models in Psychiatry, Neuromethods, vol. 19, 11 (Boulton, A A, Baker, G B, and Martin-Iverson, M T, eds), Humana Press, Totowa, NJ, pp199–232.
Commissaris, R L and Hill, R J (1995) High-dose subchronic lmipramine treatment effects on anxiety-like (conflict) behavior in rats Anxiety 1, 109–113
Commissaris, R L, Ellis, D M, Hill, T J Schefke, D M, Becker, C A, and Fontana, D J (1990) Chronic antidepressant and clomdine treatment effects on conflict behavior in the rat Pharmacol Biochem Behav 37, 167–176
Commissaris, R L, Humrich, J, Johns, J, Greere, D. G, and Fontana, D J (1995) The effects of monoamine oxidase (MAO) inhibitors on conflict behavior in the rat Behav Pharmacol 6, 195–202
Cook, L and Davidson, A B (1973) Effects of behaviorally active drugs in a conflict-punishment procedure in rats, in The Benzodiazepines ((Garattini, S., Mussini, E and Randall, L O.), eds), Raven, New York, pp. 327–345
Cook, M. and Mineka, S (1990) Selective associations in the observational con ditioning of fear in rhesus monkeys J Exp Psychol Anim Behav Proc 16, 372–389.
Costall, B, Domeney, A. M, Gerrard, P A., Kelly, M. E, and Naylor, R J. (1988a) Zacopride: anxiolytic profile in rodent and primate models of anxiety J Pharm Pharmacol 40, 302–305.
Costall, B, Domeney, A. M, Farre, A. J, Kelly, M. E, Martinez, L, and Naylor, R. J (1992) Profile of action of a novel 5-hydroxytryptaminelA receptor ligand E-4424 to inhibit aversive behavior in the mouse, rat and marmoset J. Pharmacol Exp. Ther 262, 90–98.
Costall, B, Jones, B J, Kelly, M. E., Naylor, R. J and Tomkins, D M. (1989) Exploration of mice in a black and white test box’ validation as a model of anxiety Pharmacol Biochem Behav 32, 777–785
Costall, B, Hendrie, C A, Kelly, M E, and Naylor, R. J (1987) Actions of sulpiride and tiapride in a simple model of anxiety in mice. Neuropharmacol 26, 195–200
Costall, B, Kelly, M E, Naylor, R. J, and Onaivi, E. S. (1988b) Actions of buspirone in a putative model of anxiety in the mouse. JPharm. Pharmacol 40, 494–500
Costello, N L., Carlson, J. N, and Glick, S. D (1991) Acute administration of diazepam and buspirone in rats trained on conflict schedules having differ ent degrees of predictability Pharmacol Biochem Behav 40, 787–794
Craft, R M, Howard, J L, and Pollard, G T. (1988) Conditioned defensive burying as a model for identifying anxiolytics Pharmacol Biochem Behav 30, 775–780
Crawley, J N (1981) Neuropharmacology specificity of a simple animal model for the behavioral actions of benzodiazepines Pharmacol Biochem Behav 15, 695–699
Crawley, J N (1985) Exploratory behavior models of anxiety in mice Neurosct Biobehav Rev 9, 37–44
Crawley, J. N and Goodwin, F K, (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines Pharmacol Biochem Behav 13, 167–170
Crawley, J N, Skolnick, P, and Paul, S M (1984) Absence of intrinsic antago nist actions of benzodiazepine antagonists on an exploratory model of anxi ety in the mouse Neuropharmacology 23, 531–537
Critchley, MAE and Handley, S L (1987a) 5-HT 1A hgand effects in the X-maze anxiety test Br J Pharmacol 92, 660P
Critchley, M A E and Handley, S L (1987b) Effects in the X-maze model of agents acting at 5-HT 1 and 5-HT 2 receptors Psychopharmacol 93, 502–506
Cuomo, V, Cagiano, R De-Salvia, M A, Maselli, M, Renna, G, and Racagni, G (1988) Ultrasonic vocalization in response to unavoidable aversive stimuli in rats effects of benzodiazepines Life Set 43, 485–491
Cutler, M G (1991) An ethological study of the effects of buspirone and the 5-HT3 receptor antagonist, BRL 43694 (gramsetron) on behaviour during social interactions in female and male mice. Neuropharmacology 30, 299–306
Danysz, W, Plaznik, A, Kostowski, W, Malatynska, E, Jarbe, T U, Hiltunen, A J, and Archer, T (1988) Comparison of desipramine, amitriptyhne, zimehdine and alaproclate in six animal models used to investigate antide pressant drugs Pharmacol Toxicol 62, 42–50
Davis, M (1979) Diazepam and flurazepam effects on conditioned fear as mea sured with the potentiated startle paradigm Psychopharmacol 62, 1–7
Davis, M (1986) Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm Behav Neurosct 100, 814–824
Davis, M (1990) Animal models of anxiety based on classical conditioning the conditioned emotional response (CER) and the fear-potentiated startle effect Pharmacol Ther 47, 147–165
Davis, M, Cassella, J V, and Kehne, J H (1988) Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm com parison with 8-OH-DPAT and ipsapirone Psychopharmacol 94, 14–20
Davis, M., Redmond Jr, D E, and Baraban, J. M (1979) Noradrenergic ago nists and antagonists; effects on conditioned fear as measured by the poten tiated startle paradigm Psychopharmacol 65, 111–118
de Angehs, L. (1996) Experimental anxiety and antidepressant drugs the effects of moclobemide, a selective reversible MAO A inhibitor, fluoxetine and lmi-pramine in mice Naunyn Schmtedeberg’s Arch Pharmacol 354, 379–383
De Boer, S F, Slangen, J L, and van der Gugten, J (1990) Plasma catechola mine and corticosterone levels during active and passive shock-prod avoid ance behavior in rats effects of chlordiazepoxide Pharmacol Biochem Behav 47, 1089–1098
De Graff, J S, Van Riezen, H, Berendsen, H H G, and Van Delft, A M L (1985) A set of behavioral tests predicting antidepressant activity Drug Dev Res 5, 291–301
De Pablo, J. M., Ortiz-Caro, J., Sanchez-Santed, F, and Guillamon, A (1991) Effects of diazepam, pentobarbitol, scopolamine and the timing of saline injection on learned immobility in rats Physiol Behav 50, 895–899.
De Pablo, J M, Parra, A, Segovia, S, and Guillamon, A (1989) Learned immo bility explains the behavior of rats in the forced swimming test Physiol Behav 46, 229–237.
Detke, M J., Rickels, M, and Lucki, I (1995a) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants Psychopharmacol 121, 66–72
Detke, M J, Wieland, S, and Lucki, I (1995b) Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists Psychopharmacology 119, 47–54
Devoize, J L, Rigal, F, Eschaher, A, Trolese, F J, and Renoux, M (1984) Influ ence of naloxone on antidepressant drug effects in the forced swimming test in mice Psychopharmacology 84, 71–75
De Vry, J, Benz, U, Schreiber, R, and Traber, J (1993) Shock-induced ultra sonic vocalization in young adult rats a model for testing putative anti-anxi-ety agents Eur J Pharmacol 249, 331–339
Drugan, R C, Crawley, J, Paul, S M., and Skolnick, P (1987) Buspirone attenuates learned helplessness behavior in rats Drug Dev Res 10, 63–67
Drugan, R C, Ryan, S M, Minor, T R, and Maier, S F (1984) Librium pre vents the analgesia and shuttlebox escape deficit typically observed follow ing inescapable shock Pharmacol Biochem Behav 21, 749–754
Duncan, G E, Knapp, D J, Johnson, K. B, and Breese, G R. (1996) Functional classification of antidepressants based on antagonism of swim stress-induced fos-hke immunoreactivity J Pharmacol Exp Ther, 277, 1076–1089
Dunn, R W, Corbett, R, and Fielding, S (1989) Effects of 5-HT1A receptor and NMDA receptor antagonists in the social interaction test and the elevated plus maze Eur J Pharmacol 169, 1–10.
Earley, B, Glennon, M, Lally, M, Leonard, B. E, and Junien, J L (1994) Auto radiographic distribution of chohngeric muscarinic receptors and serotonin(2) receptors in olfactory bulbectomized (OB) rats after chronic treatment with mianserin and desipramine. Human Psycopharmacol Clin Exp 9, 397–407.
Egawa, T, Ichimaru, Y, Imanishi, T, and Sawa, A. (1995) Neither the 5-HT1A nor the 5-HT2A receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on forced swimming induced immo bility in mice Jap J Pharmacol 68, 71–75
Ellis, D M, Fontana, D. J, McCloskey, C and Commissaris, R. L. (1990) Chronic anxiolytic treatment effects on conflict behavior m the rat. Pharmacol Biochem Behav 37, 177–186
Engel, J, Hard, E, and Lindh, A S (1987) Effects of diazepam, ethanol and Ro 15-1788 on ultrasonic vocalization, locomotor activity and body righting in the neonatal rat Alcohol Alcoholism Suppl. 1, 709–712
Feighner, J P., Aden, G. C Fabre, L. F, Rickels, K and Smith, W T. (1983) Comparison of alprazolam, imipramine, and placebo in the treatment of depression JAMA 249, 3057–3064
Fernandez-Guasti, A and Lopez-Rubalcava, C (1990) Evidence for the involve ment of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone Psychopharmacology 101, 354–358
Fernandez-Guasti, A and Picazo, O (1990) The actions of diazepam and sero tonergic anxiolytics vary according to the gender and the estrous cycle phase Pharmacol Biochem Behav 37, 77–81.
Fernandez-Guasti, A, Hong, E, and Lopez-Rubalcava, C (1992) Species dif ferences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action Psychopharmacology 107, 61–68
File, S. E (1984) The validation of animal tests of anxiety-pharmacological implications Pol J Pharmacol Pharm 36, 505–512
File, S E (1985) Animal models for predicting clinical efficacy of anxiolytic drugs social behaviour Neuropsychobiology 13, 55–62
File, S E. (1987) The contribution of behavioral studies to the neuropharmacol ogy of anxiety Neuropharmacology 26, 877–886
File, S E and Hyde, J R G (1979) A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquihsers and stimulants Pharmacol Biochem Behav 11, 65–69
File, S E and Hyde, J R G (1978) Can social interaction be used to measure anxiety? Br J Pharmacol 62, 19–24
File, S E and Johnston, A L (1987) Chronic treatment with lmipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat. Neuropsychobiology 17, 187–192
File, S E and Mabbutt, P S. (1991) Effects of tianeptine in animal models of anxiety and on learning and memory Drug Dev Res 23, 47–56
File, S E and Pellow, S (1983) Anxiogenic action of a convulsant benzodiaz epine reversal by chlordiazepoxide Brain Res 278, 370–372
File, S E and Pellow, S. (1984a) The anxiogenic action of FG 7142 in the social interaction test is reversed by chlordiazepoxide and Ro 15-1788 but not by CGS 8216 Arch Int Pharmacodyn Ther 271, 198–205
File, S E and Pellow, S (1984b) The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide Brain Res 310, 154–156
File, S. E and Pellow, S (1985a) The anxiogenic action of RO 5-4864 in the social interaction test effect of chlordiazepoxide, RO 15-1788 and CGS 8216 Naunyn Schmiedeberg’s Arch Pharmacol 328, 225–228
File, S. E and Pellow, S (1985b) The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard Br J Pharmacol 86, 729–735
Flugy, A., Gagliano, M, Cannizzaro, C, Novara, V., and Cannizzaro, G (1992) Antidepressant and anxiolytic effects of alprazolam versus the conventional antidepressant desipramine and the anxiolytic diazepam in the forced swim test in rats Eur J Pharmacol 214, 233–238
Fontana, D J and Commissans, R L (1988) Effects of acute and chronic lmi-pramine administration on conflict behavior in the rat a potential “animal model” for the study of panic disorder? Psychopharmacology 95, 147–150
Fontana, D J, Carbary, T M and Commissaris, R L (1989) Effects of acute and chronic anti-panic drug administration on conflict behavior in the rat Psychopharmacology 98, 157–162
Garattini, S and Samanin, R (1988) Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists? Psychol. Med 18, 287–304
Garcia, J. and Koelling, R (1966) Relation of cue to consequence in avoidance learning Psychon, Sct 4, 123–124
Gardner, C R (1988) Functional in vivo correlates of the benzodiazepine ago nist-inverse agonist continuum Prog Neurobiol 31, 425–476
Gardner, C. R (1985a) Inhibition of ultrasonic distress vocalizations in rat pups by chlordiazepoxide and diazepam Drug Dev Res 5, 185–193
Gardner, C R (1985b) Distress vocalization in rats pups A simple screening method for anxiolytic drugs. J Pharmacol Meth 14, 181–187
Gardner, C R (1986) Recent developments in 5-HT-related pharmacology of animal models of anxiety Pharmacol Biochem Behav. 24, 1479–1485
Gardner, C. R. and Guy, A P (1984) A social interaction model of anxiety sen sitive to acutely administered benzodiazepines Drug Dev. Res 4, 207–216
Geoffroy, M, Mogilmcka, E, Nielson, M., and Rafaelsen, O J (1988) Effect of nifedipine on the shuttlebox escape deficit induced by inescapable shock in the rat Eur J Pharmacol 154, 277–283
Geoffroy, M, Scheel-Kruger, J, and Christensen, A. V (1990) Effect of imi-pramine in the “learned helplessness” model of depression in rats is not mimicked by combinations of specific reuptake inhibitors and scopolamine Psychopharmacology 101, 371–375
Giral, P, Martin, P., Soubne, P, and Simon, P (1988) Reversal of helpless behavior in rats by putative 5-HT1A agonists Bio Psychiat 23, 237–242
Guisti, R, Guidetti, G, Costa, E, and Guidotti, A (1991) The preferential antagonism of pentylenetetrazole proconflict responses differentiates a class of pentylenetetrazole proconflict responses differentiates a class of anxiolytic benzodiazepines with potential antipanic action. J Pharmacol Exp Ther 257, 1062–1068
Goa, K. and Ward, A. (1986) Buspirone a preliminary review of its pharmaco logical properties and therapeutic efficacy as an anxiolytic Drugs 32, 114–129
Gorka, Z, Moryl, E, and Papp, M (1996) Effect of chronic mild stress on arca dian rythms in the locomotor activity in rats Pharmacol Biochem Behav 54, 229–234
Gorka, Z., Wojtasik, E, and Kwiatek, H. (1979) Action of serotonin mimetics in the behavioural despair test in rats Commun. Psychopharmacology 3, 133–136
Graeff, F G, Audi, E A, Almeida, S S, Graeff, E. O, and Hunziker, M H L (1990) Behavioral effects of 5-HT receptor ligands in the aversive brain stimu lation, elevated plus-maze and learned helplessness tests Neurosci. Biobehav Rev 14, 501–506
Griebel, G, Misslin, R., Pawlowski, M, and Vogel, E. (1991) m-Chlorophenyl-piperazine enhances neophobic and anxious behaviour in mice Neuroreport 2, 627–629
Griebel, G., Moreau, J L, Jenck, F, Misslin, R., and Martin, J R (1994) Acute and chronic treatment with 5-HT reuptake inhibitors differentially modu late emotional responses in anxiety models in rodents. Psychopharmacology 113, 463–470
Griebel, G., Sanger, D. J., and Perrault, G. (1996) The use of the rat elevated plus-maze to discriminate between non-selective and BZ-1 (omega) (1) selective, benzodiazepine receptor ligands. Psychopharmacology 124, 245–254.
Guy, A. P. and Gardner, C. R. (1985) Pharmacological characterisation of a modified social interaction model of anxiety in the rat. Neuropsychobiology 13, 194–200
Gyertyan, I (1995) Analysis of the marble burying response marbles serve to measure digging rather than evoke burying. Behav Pharmacol 6, 24–31
Haefely, W (1994) Benzodiazepines, benzodiazepine receptors, and endogenous ligands, in Handbook of Depression and Anxiety A Biological Approach (den Boer, J A and Ad Sitsen, J M, eds), Marcel Dekker, New York, pp 573–607.
Hand, T H, Marek, G. J, and Seidon, L S (1991) Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity Psychopharmacology 105, 453–458
Handley, S L and McBlane, J W (1992) Opposite effects of fluoxetine in two animal models of anxiety Br J Pharmacol 107(Suppl.), 446P
Handley, S L and Mithani, S (1984) Effects of alpha-adrenoreceptor agonists and antagonists in a X-maze-exploration model of ‘fear’-motivated behaviour Naunyn-Schmtedeberg’s Arch Pharmacol 327, 1–5
Harto, N E, Branconnier, R. J, Spera, K F, and Dessain, E C (1988) Clinical profile of gepirone, a nonbenzodiazepine anxiolytic Psychopharmacol Bull 24, 154–160
Heller, A H, Beneke, M, Kuemmel, B, Spencer, D, and Kurtz, N M (1990) Ipsapirone evidence for efficacy in depression Psychopharmacol Bull 26, 219–222
Hijzen, T H and Slangen, J L (1989) Effects of midazolam, DMCM and lin dane on potentiated startle in the rat. Psychopharmacology 99, 362–365
Hijzen, T. H., Houtzager, S. W., Joordens, R J, Oliver, B, and Slangen, J L (1995) Predicitive validity of the potentiated startle response as a behavioral model for anxiolytic drugs Psychopharmacology 118, 150–154
Hogg, S (1996) A review of the validity and variability of the elevated plus-maze as an animal model of anxiety Pharmacol Biochem Behav 54, 21–30
Howard, J L and Pollard, G T (1990) Effects of buspirone in the Geller-Seifter conflict test with incremental shock Drug Dev Res 19, 37–47
Ichimaru, Y, Egawa, T, and Sawa, A. (1995) 5-HTlA-receptor subtype medi ates the effect of fluvoxamme, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice Jap J Pharmacol 68, 65–70
Insel, T R (1989) Decreased in vivo binding to brain benzodiazepine receptors during social isolation Psychopharmacology 97, 142–144
Insel, T. R, Hill J. L. and Mayor, R B (1986) Rat pup ultrasonic isolation calls possible mediation by the benzodiazepine receptor complex Pharmacol Biochem Behav 24, 1262–1267
Jackson, A. Koek, W, and Colpaert, F C (1995) Can the DRL 72s schedule selec tively reveal antidepressant drug activity? Psychopharmacology 117, 154–161
Jenkins, S W, Robinson, O S, Fabre, Jr L F, Andary, J J, Messina, M E, and Reich, L. A (1990) Gepirone in the treatment of major depression J Clin Psychopharmacol 10, 77S.
Johnston, A L and File, S E (1989a) Yohimbine’s anxiogenic action, evidence for noradrenergic and dopaminergic sites Pharmacol Biochem Behav 32, 151–156
Johnston, A L. and File, S E (1989b) Sodium phenobarbitone reverses the anxiogenic effects of compounds acting at three different central sites Neuropharmacology 28, 83–88
Johnston, A L and File, S. E. (1988) Profiles of the antipanic compounds, triazolobenzodiazepmes and phenelzine, in two animal tests of anxiety Psychiat Res 25, 81–90
Joly, D and Sanger, D. J (1986) The effects of fluoxetine and zimelidine on the behaviour of olfactory bulbectomized rats Pharmacol Biochem Behav 24, 199–204
Jonas, J M and Cohon, M S (1993) A comparison of the safety and efficacy of alprazolam versus other agents in the treatment of anxiety, panic and depression review of the literature J Clin Psychiat 54, 25–48
Jones, G H, Schneider, C, Schneider, H H, Seider, J, Cole, B J, Stephans, D. N (1994) Comparison of several benzodiazepine receptor ligands in two mod els of anxiolytic activity in the mouse, an analysis based on fractional recep tor occupancies Psychopharmacology 114, 191–199
Joordens, R J, Hijzen, T H, Peeters, B W, and Olivier, B (1996) Fear potenti ated startle response is remarkably similar in two laboratories Psychophar macology 126, 104–109
Kametam, H, Numura, S, and Shimizu, J (1983) The reversal of antidepres sants on the escape deficit induced by inescapable shocks in rats Psychop harmacology 80, 206–208
Kehne, J H, Cassella, J V, and Davis, M (1988) Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm Psychopharmacology 94, 8–13
Kehne, J. H, McCloskey, T C Baron, B M Chi, E M. Harnson, B L Whitten, J P and Palfreyman, M G (1991) NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations Eur J Pharmacol 193, 283–292
Kelly, J P and Leonard, B E. (1994) The effect of tianeptine and sertraline in three animal models of depression Neuropharmacology 33, 1011–1016.
Kelly, J P and Leonard, B E (1996) Effects of chronic desipramine on waiting behaviour for a food reward in olfactory bulbectomized rats J Psycho-pharmacol 10, 153–156
Kennedy, A. J., Gibson, E L, O’Connell, M T, and Curzon, G (1993) Effects of housing, restraint and chronic treatments with mCPP and sertraline on behavioural responses to mCPP. Psychopharmacology 113, 262–268
Kennett, G A (1992) 5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model Psychopharmacology 107, 379–384
Kilfoil, T, Michel, A, Montgomery, D, and Whiting, R. L. (1989) Effects of anxiolytic and anxiogemc drugs on exploratory activity in a simple model of anxiety in mice. Neuropharmacology 28, 901–905.
Kitata Y, Miyauchi, T, Satoh, A., and Satoh, S, (1981) Effects of antidepres sants on duration of immobility in the rat forced swimming test Eur J Pharmacol 72, 145–152
Klein, D F (1981) Anxiety reconceptualized, in Anxiety. Research and Changing Concepts (Klein, D F and Rabkm, J, eds), Raven, New York, pp 235–262
Korte, S M and Bohus, B (1990) The effect of ipsapirone on behavioral and cardiac responses in the shock-probe/ defensive burying test in male rats Eur J Pharmacol 181, 307–310.
Kostowski, W, Dyr, W, Krzascik, P., and Archer, T. (1992) 5-Hydroxtryptamine 1A receptor agonists in animal models of depression and anxiety. Pharmacol Toxicol 71, 24–30
Kshama, D, Hnshikeshavan, H J, Shanbhogue, R, and Munonyedi, U S (1990) Modulation of baseline behavior in rats by putative serotonergic agents in three ethoexpenmental paradigms Behav Neural Biol 54, 234–253
Lai, H and Emmett-Oglesby, M W (1983) Behavioral analogues of anxiety Animal models Neuropharmacology 22(12B), 1423–1444
Lehmann, H E and Ban, T A (1971) Effects of psychoactive drugs on conflict avoidance behavior in human subjects Acta Nerv Sup 13, 82–85
Li, A A., Marek, G J, Hand, T H, and Seidon, L S (1990) Antidepressant-like effects of trazodone on a behavioral screen are mediated by trazodone, not the metabolite m-chlorophenylpiperazine Eur J Pharmacol 177, 137–144
Lightowler, S, Kennett, G A, Williamson, I J, Blackburn, T P, and Tulloch, I F (1994) Anxiolytic-like effect of paroxetine in a rat social interaction test Pharmacol Biochem Behav 49, 281–285
Linnoila, M, Eckardt, M, Durcan, M, Lister, R, and Martin, P (1987) Interac tions of serotonin with ethanol clinical and animal studies Psychopharmacol Bull 23, 452–457
Lister, R G (1990) Ethologically-based animal models of anxiety disorders Pharmac Ther 46, 321–340
Lister, R G (1987) The use of a plus-maze to measure anxiety in the mouse Psychopharmacology 92, 180–185
Lopez-Rubalcava, C, Fernandez-Gausti, A, Urbaholmgren, R (1996) Age-dependant differences in the rat conditioned defensive burying behavior effect of 5-HT1A compounds Dev Psychobiol 29, 157–169
Luscombe, G P, Mazurkiewicz, S E, and Buckett, W R (1990) Evaluation of tricyclic antidepressants in the elevated plus-maze in rats anxiolytic effects of dothiepin and doxepme Br J Pharmacol 100(Suppl.), 356P
Luttinger, D, Freedman, M, Hamel, L, Ward, S J, and Perrone, M (1984) The effects of serotonin antagonists in a behavioral despair procedure m mice Eur J Pharmacol 107, 53–58
Maier, S F (1990) Role of fear conditioning in mediating shuttle learning deficit produced by inescapable shock J Exp Psychol An Behav Proc 16, 137–149
Maisonnette, S, Morato, S, and Brandao, M L (1993) Role of resociahzation and of 5-HT1A receptor activation on the anxiogenic effects induced by iso lation in the elevated plus-maze test Physiol Behav 54, 753–758
Maj, J, Rogoz, Z, Skuza, G, and Sowinska, H (1992) Effects of MK-801 and antidepressant drugs in the forced swimming test in rats Eur Neuropharmacol 2, 37–41
Maj, J, Rogoz, Z, and Skuza, G (1982) Fluvoxamine, a new antidepressant drug, failed to show antiserotonin activity Eur J Pharmacol 81, 287–292
Mansbach, R S and Geyer, M. A (1988) Blockade of potentiated startle respond ing in rats by 5-hydroxytryptamine 1A receptor hgands. Eur J Pharmacol 156, 375–383
Marek, G J and Seiden, L S (1988a) Effects of selective 5-hydroxytryptamine-2 and nonselective 5-hydroxytryptamine antagonists on the differential-reinforcement-of-low-rate 72-second schedule J Pharmacol Exp Ther 244, 650–658
Marek, G. J and Seiden, L S (1988b) Selective inhibition of MAO-A, not MAO-B, results in antidepressant-like effects on DRL 72s behavior Psychopharma cology 96, 153–160
Marek, G J, Li, A. A, and Seiden, L. S (1989) Evidence for involvement of 5-hydroxytryptamine 1 receptors in antidepressant-hke drug effects on dif-ferential-reinforcement-of-low-rate 72-second behavior J Pharmacol Exp Ther 250, 60–71
Marek, G.J., Heffner, T.G., Richards, J B., Shaughnessy, R. A, Li, A A., and Seidon, L S. (1993) Effects of caffeine and PD 116, 600 on the differential-reinforcement-of-low-rate 72-S (DRL 72-S) schedual of reinforcement Pharmacol Biochem Behav 45, 987–990
Marks, I M. (1987) Fears, Phobias, and Rituals, Oxford University Press, New York
Martin, P. (1991) l-(2-Pnmindyl)-piperazine may alter the effects of the 5-HT1A agonists in the learned helpless paradigm. Psychopharmacology 104, 275–278
Martin, P and Peuch, A J (1991) Is there a relationship between 5-HT1B recep tors and the mechanisms of action of antidepressant drugs in the learned helplessness paradigm in rats Eur J Pharmacol 192, 193–196
Martin, P and Peuch, A J. (1996) Antagonism by benzodiazepines of the effects of serotonin, but not norepinephrine, uptake blockers in the learned help lessness paradigm in rats Biol Psychiat 39, 882–890.
Martin, P, Soubne, P, and Puech, A J (1990) Reversal of helpless behavior by serotonin uptake blockers in rats. Psychopharmacology 101, 403–407.
Martin, P, Soubne, P., and Simon, P (1986) Noradrenergic and opiod media tion of tricychc-induced reversal of escape deficits caused by inescapable shock pretreatment in rats Psychopharmacology 90, 90–94.
Martin, P, Soubne, P., and Simon, P (1987) The effect of monoamine oxidase inhibitors compared with classical tricyclic antidepressants on learned help lessness paradigm Prog Neuro-Psychopharmacol Bio Psychiat 11, 1–7
Mason, P, Skinner, J, and Luttinger, D. (1987) Two tests in rats for antianxiety effect of clinically anxiety attenuating antidepressants Psychopharmacology 92, 30–34
McCloskey, T. C, Paul, B K, and Commissans, R. L. (1987) Buspirone effects in an animal conflict procedure comparison with diazepam and phenobar-bital. Pharmacol Biochem Behav. 27, 171–175.
McGuire P S. and Seidon, L S (1980) Differential effects of imipramine in rats as a function of DRL schedual Pharmacol Biochem Behav 13, 691–694
McNally, R J. (1987) Preparedness and phobias, a review Psychol Bull 101, 283–303
McNamara, M. G, Kelly, J P, and Leonard, B E. (1996) Some behavioural and neurochemical effects of ipsapirone in two rodent models of depression J Psychopharmacol 10, 126–133
Meert, T F and Colpaert, F C (1986) The shock probe conflict procedure A new assay responsive to benzodiazepines, barbiturates and related com pounds Psychopharmacol 88, 445–450.
Meneses, A. and Hong, E. (1993) Modification of the anxiolytic effects of 5-HT1Aagomsts by shock intensity. Pharmacol Biochem Behav 46, 569–573
Miczek, K A, Weerts, E M, Vivan, J A, and Barros, H M. (1995) Aggression, anxiety and vocalizations in animals. GABAA and 5-HT anxiolytics Psychop harmacology 121, 38–56
Mineka, S. (1985) Animal models of anxiety-based disorders their usefulness and limitations, in Anxiety and Anxiety Disorders (Tuma, A. H. and Maser, J. D, eds.), Erlbaum, Hillsdale, N J, pp 191–244
Mineka, S, Keir, R, and Price, V (1980) Fear of snakes m wild-and lab-reared rhesus monkeys Amm Learn Behav 8, 653–663
Monleon, S, D’Aquila, P, Parra, A, Simon, V M, Brain, P F, and Willner, P (1995) Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by lmipramine. Psychopharmacology 117, 453–457
Montgomery, S A and Fineberg, N (1989) Is there a relationship between serotonin receptor subtypes and selectivity of response in psychiatric ill nesses? Br J Psychtat 155(Suppl.8), 63–70
Moreau, J L, Bourson, A, Jenck, F, Martin, J R, and Mortas, P (1994) Cura tive effects of the atypical antidepressant mianserin in the chronic mild stress-induced anhedonia model of depression J Psychtat Neurosa 19, 51–56
Moreau, J L, Jenck, F, Martin, J R, Mortas, P, and Haefely, W E (1992) Anti depressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats Eur Neuropharmacol 2, 43–49
Moreau, J L, Jenck, F, Martin, J R, Mortas, P, and Haefely, W. (1993) Effects of moclobemide, a new generation reversible Mao-A inhibitor, in a novel animal model of depression Pharmacopsychiatry 26, 30–33
Moreau, J L, Scherschhcht, R., Jenck, F, and Martin, J R (1995) Chronic mild stress induced anhedonia model of depression sleep abnormalities and cura tive effects of electroshock treatment Behav Pharmacol 6, 682–687
Moser, P C (1989) An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone Psychopharmacology 99, 48–53
Moser, P. C, Tncklebank, M. D Middlemiss, D N., Mir, A K Hibert, M F and Fozard, J R (1990) Characterization of MDL 73005EF as a 5-HT 1A selective ligand and its effects in animal models of anxiety comparison with buspirone, 8-OH-DPAT and diazepam Br J Pharmacol 99, 343–349
Motta, V, Maisonnette, S, Morato, S, Castrechini, P, and Brandao, M L (1992) Effects of blockade of 5-HT2 receptors and activation of 5-HT1A receptors on the exploratory activity of rats in the elevated plus-maze Psychopharma cology 107, 135–139
Mudunkotuwa, N T and Horton, R W (1996) Desipramine administration in the olfactory bulbectomized rat changes in brain beta adrenoceptor and 5 HT2A binding sites and their relationship to behaviour Br J Pharmacol 117, 1481–1486
Murua, V S and Molina, V A. (1991) Antidepressants reduce inactivity during both inescapable shock administration and shuttle-box testing Eur J Pharmacol 204, 187–192.
Muscat, R, Papp, M, Willner, P (1992) Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotihne Psychopharma cology 109, 433–438.
Nakagawa, Y, Ishima, T, Ishibashi, Y, Yoshi, T, and Takashima, T (1996) Involvement of GABA(B) receptor systems in action of antidepressants baclofen but not bicuculline attenuates the effects of antidepressants on the forced swim test in rats Brain Res 709, 215–220
Nanry, K P, Howard, J L, and Pollard, G T (1991) Effects of buspirone and other anxiolytics on punished key-pecking in the pigeon Drug Dev Res 24, 269–276
Nastiti, K, Benton, D, Brain, P F., and Haug, M. (1991) The effects of 5-HT receptor ligands on ultrasonic calling in mouse pups Neurosci Biobehav Rev 15, 483–487.
Nevins, M E. and Anthony, E W (1994) Antagonists at the serotonin-3 recep tor can reduce the fear-potentiated startle response in the rat: evidence for different types of anxiolytic activity? J Pharmacol. Exp. Ther 268, 248–254
Nijssen, A and Schelvis, P R (1987) Effect of an anti-anxiety drug in a learned helplessness experiment Neuropsychobtology 18, 195–198
Nishimura, H, Ida, Y, Tsuda, A, and Tanaka, M (1989) Opposite effects of diazepam and beta-CCE on immobility and straw-climbing behavior of rats in a modified forced-swim test Pharamcol Biochem Behav 33, 227–231
Nishimura H and Tanaka, M (1992) Effects of alprazolam on anxiety-related behavior of rats in a modified forced swim-test employing straw suspen sion Pharmacol Biochem Behav 41, 425–427
Nishimura H, Tanaka, M, Tsuda, A,, and Gondoh, Y. (1993) Atypical anxiolytic profile of buspirone and a related drug, SM-3997, in a modified forced swim test employing straw suspension. Pharmacol Biochem Behav 46, 647–651.
Nishimura, H, Tsuda, A, Ida, Y, and Tanaka, M (1988) The modified forced-swim test in rats influence of rope-or straw-suspension on climbing behav ior Physiol Behav 43, 665–688
Njung’e, K and Handley, S L (1991a) Evaluation of marble-burying as a model of anxiety Pharmacol Biochem Behav 38, 63–67.
Njung’e, K and Handley, S L (1991b) Effects of 5-HT uptake inhibitors, ago nists and antagonists on the burying of harmless objects by mice, a putative test for anxiolytic agents Br J Pharmacol 104, 105–112
Noirot, E (1972) Ultrasounds and maternal behavior in small rodents Dev Psychobiol 5, 371–387
Nomura, S, Okada, H, Naruse, R., and Yamaoka, K. (1991) The tail supension test for screening antidepressant drugs comparison of movement in ICR and NMRImice Jap J Psychiat Neurol 45, 113–114
Noreika, L., Pastor, G, and Liebman, J (1981) Delayed emergence of antide pressant efficacy following withdrawl in olfactory bulbectomized rats Pharmacol Biochem Behav 15, 393–398.
O’Connor, W T. and Leonard, B E (1988) Behavioural and neuropharmaco-logical properties of dibenzazepines, desipramine and lofepraminc studies on the olfactory bulbectomized rat model of depression Prog NeuroPsychopharmacol Biol Psychiat 12, 41–51
O’Connor, W T and Leonard, B E. (1986) Effect of chronic administration of the 6-aza analogue of mianserin (ORG 3770) and its enantiomers on behaviour and noradrenaline metabolism of olfactory bulbectomized rats in the ‘openfield’ apparatus Neuropharmacology 25, 267–270
O’Connor, W. T., Earley, B., and Leonard, B E (1985) Antidepressant proper ties of the triazolobenzodiazepines alprazolam and adinazolam; studies on the olfactory bulbectomized rat model of depression Br. J Clin Pharmacol 19, 45S-56S
O’Donnell, J M and Seidon, L S (1982) Effects of monamine oxidase inhibi tors on performance during differential reinforcement of low response rate Psychopharmacology 78, 214–218
Ohman, A (1986) Face the beast and fear the face. Animal and social fears as prototypes for evolutionary analyses of emotion Psychophysiology 23, 123–145
Ohman, A, Dimberg, U, and Ost, L G (1985) Animal and social phobias bio logical constraints on learned fear responses, in Theoretical Issues in Behavior Therapy (Reiss, S. and Bootzin, R R., eds) Academic, New York, pp 123–175
Olajide, D. and Lader, M (1984) A double-blind comparison of buspirone and diazepam in outpatients with chronic anxiety states Abstract at C I N P meeting, Florence
Olds, J and Milner, P (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain J Comp Physiol Psychol 47, 419–427
Olivier, B, Molewrjk, E., van Oorshot, R, van der Poel, G, Zethof, T, van der Heyden, J, and Mos, J (1994) New animal models of anxiety Eur Neuropsychopharmacol 4, 93–102
Onaivi, E. S and Martin, B R (1989) Neuropharmacological and physiological validation of a computer-controlled two-compartment black and white box for the assesment of anxiety Prog Neuro-Psychopharmacol Biol Psychiat 13, 963–976
O’Neill, M F, Fernandez, A G, and Palacios, J M (1996) GR 127935 blocks the locomotor and antidepressant like effects of RU 24969 and the action of anti depressants in the mouse tail suspension test Pharmacol Biochem Behav 53, 535–539
Palaska, E, Erol, D, and Demirdamar, R (1996) Synthesis and antidepressant activities of some 1, 3, 5 triphenyl 2 prazohnes Eur J Med Chem 31, 43–47
Paslawski, T., Treit, D, Baker, G. B, George, M, and Coutts, R T (1996) The antidepressant drug phenelzine produces antianxiety effects in the plus-maze and increases rat brain GABA Psychopharmacology 127, 19–24
Papp, M, Moryl, E, and Willner, P (1996) Pharmacological validation of the chronic mild stress model of depression Eur J Pharmacol 296, 129–136
Papp, M, Muscat, R, and Willner, P (1992) Additive effects of chronic treat ment with antidepressant drugs and intermittent treatment with a dopam ine agonist Eur Neuropsychopharmacol 2, 121–125
Papp, M, Willner, P, and Muscat, R. (1991) An animal model of anhedonia attenutation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology 104, 225–229
Paul, S M (1988) Anxiety and depression a common neurobiological substrate? J Clin Psychiatry 49, 13–16.
Paul, I A, Duncan, G E, Kuhn, C, Mueller, R A, Hong, J S, and Breese, G R (1990) Neural adaptation in lmipramme-treated rats processed in forced swimming test assessment of time course, handling, rat strain and amine uptake J Pharmacol Exp Ther 252, 997–1005
Pecknold, J C, Familamin, P Chang, H Wilson, R Alarcia, J and McClure, D J (1985) Buspirone, anxiolytic? Prog Neuropsychopharmacol Biol Psychiat 9, 639–642
Pellow, S. (1986) Anxiolytic and anxiogenic drug effects in a novel test of anxi ety are exploratory models of anxiety in rodents valid? Meth Find Expt Clin Pharmacol 8, 557–565
Pellow, S, Chopin, P, File, S E., and Bnley, M (1985) Validation of open closed arm entries in an elevated plus-maze as a measure of anxiety in the rat J Neurosci Meth 14, 149–167
Pellow, S and File, S E (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze a novel test of anxiety in the rat Pharmacol Biochem Behav 24, 525–529
Pellow, S and File, S. E (1987) Can anti-panic drugs antagonise the anxiety produced in the rat by drugs acting at the GABA-benzodiazepine receptor complex? Neuropsychobiology 17, 60–65
Pellow, S, Johnston, A L, and File, S E. (1987) Selective agonists and antago nists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat J Pharm Pharmacol 39, 917–928
Peroutka, S J (1985) Selective interaction of novel anxiolytics with 5-hydrox-ytryptamine 1A receptors Biol Psychiat 20, 971–979
Perrault, G, Morel, E., Zivkovic, B, and Sanger, D J (1992) Activity of htoxetine and other serotonin uptake inhibitors in the tail suspension test m mice Pharmacol. Biochem Behav 42, 45–47
Peterson, C, Maier, S F, and Seligman, MEP (1993) Learned Helplessness A Theory of the Age of Personal Control, Oxford University Press, New York
Petty, F (1995) GABA and mood disorders, a brief review and hypothesis J Affect Disorders 34, 275–281
Picazo, O Lopez-Rubalcava, C, and Fernandez-Gausti, A (1995) Anxiolytic effect of the 5-HT1A compounds 8-hydroxy-2-(di-n-propylamino)tetrahn and ipsapirone in the social interaction paradigm evidence of a presynaptic action Brain Res Bull 37, 169–175
Pich, E M and Samanin, R (1986) Dismhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats possible role of dopamine Psychopharmacology 89, 125–130
Pinel, J P J and Treit, D (1983) The conditioned defensive burying paradigm and behavioral neuroscience, in Behavioral Approaches to Brain Research (Robinson, T, ed), Oxford Press, Oxford, pp 212–234
Pinel, J. P J and Treit, D (1978) Burying as a defensive response in rats. J Comp Physiol Psychol 92, 708–712
Pollard, G T and Howard, J L (1990) Effects of drugs on punished behavior pre-clinical test for anxiolytics Pharmacol Ther 45, 403–424
Popik, P and Vetulani, J (1993) Similar action of lmipramine and argmme-vasopressin in the social interaction test. Pol J Pharmacol 45, 323–325
Porsolt, R. D, Anton, G., Blavet, N, and Jalfre, M (1978) Behavioural despair in rats a new model sensitive to antidepressant treatments Eur J Pharmacol 47, 379–391
Porsolt, R D., Bertin, A, and Jalfre, M (1977a) Behavioral despair in mice a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229, 327–336
Porsolt, R. D, Bertin, A, Blavet, N., Daniel, ML, and Jalfre, M. (1979) Immobility induced by forced swimming in rats effects of agents which modify central catecholamine and serotonin activity Eur J Pharmacol 57, 201–210
Porsolt, R D, Chermat, R, Lenegre, A, Avnl, I., Janvier, S, and Steru, L (1987) Use of the automated tail suspension test for the primary screening of psy chotropic drugs Arch Int Pharmacodyn. Ther 288, 11–30
Porsolt, R D, LePichon, M, and Jalfre, M (1977b) Depression a new animal model sensitive to antidepressant treatments Nature 266, 730–732
Possidente, B, Lumia, A R, McGinnis, M Y, Rapp, M, and McEldowney, S (1996) Effects of fluoxetine and olfactory bulbectomy on mouse arcadian activity rythms Brain Res 713, 108–113
Prezgahnski, E, Moryl, E, and Papp, M. (1995) The effect of 5-HT1A receptor ligands in a chronic mild stress model of depression Neuropharmacology 34, 1305–1310.
Prunell, M, Esconhuela, R M, Fernandez-Tereul, A, Nunez, J F, and Tobena, A (1994) Anxiolytic profiles of alprazolam and ethanol m the elevated plus-maze test and the early acquisition of shuttle-box avoidance. Pharmacol Res 29, 37–46
Rausch, J L, Reugg, R, and Moeller, F G (1990) Gepirone as a 5-HT1A agonist in the treatment of major depression. Psychopharmacol Bull 26, 169–171
Reis de Ohvera, I, Diquet, B, Van der Meersch, V, Dardennes, R, Gonidec, J, and do Prado-Lima, P A (1990) Self-inhibiting action of nortriptyline’s anti-Immobilty effect at high plasma and brain levels in mice Psychopharmacology 102, 553–556
Richards, J B, Sabol, K E, Hand, T H, Jolly, D C, Marek, G J, and Seidon, L S. (1994) Buspirone, gepirone, ipsapirone, and zalospirone have distinct effects on the differential-reinforcement-of-low-rate 72-s schedual when com pared with 5-HTP and diazepam Psychopharmacology 114, 39–46
Richardson, J S (1991) The olfactory bulbectomized rat as a model of major depressive disorder, in Neuromethods Animal Models in Psychiatry, (Boulton, A A, Baker, G B, and Martin-Iverson, M T, eds), Humana Press, Totowa, NJ, pp 61–79
Rickels, K, Amsterdam, J, Clary, C, Hassman, J, London, J, Puzzuoli, G, and Schweizer, E (1990) Buspirone in depressed outpatients a controlled study Psychopharmacol Bull 26, 163–167
Rickels K, Downing R, Schweizer E, and Hassman H (1993) Antidepressants for the treatment of generalized anxiety disorder Arch Gen Psychtat 50, 884–895
Rickels, K, Feighner, J P, and Smith, W T (1985) Alprazolam, amitnptylme, doxepine and placebo in the treatment of depression Arch Gen Psychtat 42, 134–141
Rocha, B, Rigo, M., Di Scala, G., Sander, G, and Hoyer, D (1994) Chronic mianserin or eltoprazine treatment in rats effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels Eur J Pharmacol 262, 125–131.
Rohmer, J G, Di Scala, G, and Sandner, G (1990) Behavioral analysis of the effects of benzodiazepine receptor ligands in the conditioned burying para digm Behav Brain Res 38, 45–54
Roth, M (1990) Anxiety disorders-normal, pathological and episodic a dilemma for aetiology, in Handbook of Anxiety, vol 3 (Burrows, G D, Roth, M., and Noyes Jr, R, eds), Elsevier, Amsterdam, pp. 439–477
Rudzik, A. D, Hester, J B, Tang, A H, Straw, R. N and Priis, W (1973) Triazolobenzodiazepmes, a new class of central nervous system depressant compounds, in The Benzodiazepines (Garattim, S, Mussini, E and Randall, L O, eds), Raven, New York, pp 285–326
Sampson, D, Willner, P, and Muscat, R. (1991) Reversal of antidepressant action by dopamine antagonists in an animal model of depression Psychopharma cology 104, 491–495.
Sanchez, C (1995) Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two compartment black and white test box. Pharmacol Toxicol 77, 71–78.
Sanger, D J (1990) Effects of buspirone and related compounds on suppressed operant responding in rats J Pharmacol Exp Ther 254, 420–426.
Sanger, D. J (1991) Animal models of anxiety and the screening and develop ment of novel anxiolytic drugs, in Animal Models of Psychiatry, II (Boulton, A A, Baker, G G, and Martin-Iverson, M, eds), Humana Press, Totowa, NJ, pp 147–198
Sanger, D J (1992) Increased rates of responding produced by buspirone-like compounds in rats J Pharmacol Exp Ther 261, 513–517
Schechter, M D and Chance, W T (1979) Non-specificty of “behavioral despair” as an animal model of depression Eur J Pharmacol 60, 139–142
Schefke, D M, Fontana, D J and Commissans, R L (1989) Anti-conflict effi cacy of buspirone following acute versus chronic treatment Psychopharmacology 99, 427–429
Seidon, L S, Dahms, J L, and Shaughnessy, R A (1985) Behavioral screen for antidepressants the effects of drugs and electroconvulsive shock on perfor mance under a differenhal-reinforcement-of-low-rate schedual. Psychopharmacology 86, 55–60
Sehgman, M E P (1971) Phobias and preparedness. Behav Ther 2, 307–320
Seligman, M E P (1975) Helplessness On Depression, Development, and Death Freeman, San Francisco
Shanks, N and Ainsman H (1989) Strain-specific effects of antidepressants on escape deficits induced by inescapable shock Psychopharmacology 99, 122–128
Sheehan, D V., Raj, A B Sheehan, K. H., and Soto, S (1990) Is buspirone effec tive for panic disorder? J Clin Psychopharmacol 10, 3–11
Sheehan, D V., Raj, A. B Sheehan, K H, and Soto, S. (1988) The relative effi cacy of buspirone, imipramine and placebo in panic disorder a preliminary report Pharmacol Biochem Behav 29, 815–817
Shephard, R A. (1986) Neurotransmitters, anxiety and benzodiazepines a behavioral review Neurosci Biobehav Rev 10, 449–461.
Sherman, A D and Petty, F (1980) Neurochemical basis of the action of antide pressants on learned helplessness. Behav Neural Biol 30, 119–134
Sherman, A. D., Sacquitne, J L, and Petty, F (1982) Specificity of the learned helplessness model of depression Pharmacol. Biochem Behav 16, 449–454
Shimada, T, Matsumoto, K, Osanai, M., Matsuda, H, Terasawa, K, and Watanabe, H (1995) The modified light/dark transition test in mice, evalu ation of classic and putative anxiolytic and axiogenic drugs. Gen Pharmacol 26, 205–210
Skolnick, P, Paul, S M., and Weissman, B A (1984) Preclinical pharmacology of buspirone hydrochloride. Pharmacotherapy 4, 308–314.
Soderpalm, B, Eriksson, E, and Engel J A (1989b) Anticonfhct and rotarod impairing effects of alprazolam and diazepam in rat after acute and subchronic administration. Prog Neuropsychopharmacol. Biol Psychiat 13, 269–283
Soderpalm, B, Hjorth, S, and Engel, J. A, (1989a) Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery’s conflict test Pharmacol Biochem Behav 32, 259–265
Soderpalm, B, Lundin, B., and Hjorth, S (1993) Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-hke action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic treatment Eur J Pharmacol 239, 69–73
Sommermeyer, H, Schreiber, R, Greuel, J M, De Vry, J, and Glaser, T (1993) Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat neu-robiological correlates Eur J Pharmacol 240, 29–37
Song, C, Earley, B., and Leonard, B E (1996) Behavioural and immunological effects of the anthistamme terfenadine in olfactory bulbectomized rats Eur Neuropsychopharmacol 6, 157–162
Stefanski, R Palejko, W., Kotowski, W, and Plaznik, A (1992) The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety Neuropharmacology 31, 1252–1258
Steru, L Chermat, R, Thierry, B, Mico, J A, Lenegre, A., Steru, M, Simon, P, and Porsolt, R D (1987) The automated tail suspension test a computerized device which differentiates psychotropic drugs Pro Neuropharmacol Biol Psych 11, 659–671
Steru, L Chermat, R, Thierry, B, and Simon, P (1985) The tail suspension test a new method for screening antidepressants in mice Psychopharmacology 85, 367–370
Suranyi-Cadotte, B E Bodnoff, S R, and Welner, S A (1990) Antidepressant-anxiolytic interactions involvement of the benzodiazepine-GABA and sero tonin systems Prog Neuropharmacol Biol Psychiatr 14, 633–654
Tejedor-Real, P, Mico, J A, Maldonado, R, Roques, B P, and Gibert-Rahola, J (1995) Implication of endogenous opiod system in the learned helpless ness model of depression Pharmacol Biochem Behav 52, 145–152
Telner, J I and Singhal, R L (1981) Effects of nortriptyline treatment on learned helplessness in the rat Pharmacol Biochem Behav 14, 823–826
Teste, J F, Pelsy-Johann, I, Decelle, T., and Boulu, R G (1993) Anti-immobil-lty activity of different anti-depressant drugs in normal or reserpinized mice Fund Clin Pharmacol 7, 219–226
Thiebot, M H (1983) Behavioral models of anxiety in animals Encephale 9(4 Suppl. 2), 167B–176B
Thiebot, M. H., Soubne, P, and Sanger, D. (1988) Anxiogenic properties of beta-CCE and FG 7142. a review of promises and pitfalls. Psychopharmacology 94, 452–463.
Thiebot, M. H, Soubne, P, and Simon, P (1985) Is delay of reward mediated by shock-avoidance behavior a critical target for anti-punishment effects of diazepam in rats? Psychopharmacology 87, 473–479
Tonoue, T, Ashida, Y Makino, H, and Hata, H (1986) Inhibition of shock-ehcited ultrasonic vocalization by opioid peptides in the rat a psychotropic effect. Psychoneuroendocrinology 11, 177–184
Tonoue, T, Iwasawa, H, and Naito, H (1987) Diazepam and endorphin in dependently inhibit ultrasonic distress calls in rats Eur J Pharmacol 142, 133–136
Treit, D (1994) Animal models of anxiety and anxiolytic drug action, in Hand book of Depression and Anxiety A Bwlogical Approach (den Boer J A, Ad Sitsen J M., eds) Marcel Dekker, New York, pp 201–224
Treit, D. (1985a) Animal models for the study of anti-anxiety agents a review Neurosci Biobehav Rev 9, 203–222.
Treit, D. (1985b) Evidence that tolerance develops to the anxiolytic effect of diazepam in rats. Pharmacol Biochem Behav 22, 383–387.
Treit, D. (1985c) The inhibitory effect of diazepam on defensive burying. anxiolytic vs analgesic effects Pharmacol. Biochem Behav 22, 47–52.
Treit, D., (1987) Ro 15-1788, CGS 8216, picrotoxin, and pentylenetetrazol do they antagonize anxiolytic drug effects through an anxiogenic action? Brain Res Bull 19, 401–405.
Treit, D (1990) A comparison of anxiolytic and nonanxiolytic agents in the shock-probe/burying test for anxiolytics. Pharmacol Biochem Behav 36, 203–205.
Treit, D and Fundytus, M (1988) A comparison of buspirone and chlordiazep-oxide in the shock-probe/burying test for anxiolytics. Pharmacol Biochem Behav 30, 1071–1075
Treit, D., Lolordo, V M, and Armstrong, D E (1986) The effects of diazepam on “fear” reactions in rats are modulated by environmental constraints on the rat’s defensive repertoire Pharmacol Biochem Behav 25, 561–565
Treit, D., Pinel, J. P, and Fibiger, H C. (1981) Conditioned defensive burying a new paradigm for the study of anxiolytic agents Pharmacol Biochem Behav 15, 619–626
Tsuda, A, Ida, Y, and Tanaka, M (1988) The contrasting effects of diazepam and yohimbine on conditioned defensive burying in rats Psychobiology 16, 213–217
Tsuda, A, Ida, Y Nishimura, H., and Tanaka, M (1989) Anxiogenic effects of (3-CCE as measured in two different conditioning paradigms Psychobiology 17, 202–206
Tyrer, P J (1990) The division of neurosis a failed classification J Roy Soc Med 83, 614–616
Tyrer, P and Tyrer, J. (1994) Antidepressive drugs for treatment of anxiety dis orders-and vice versa, in, Handbook of Depression and Anxiety A Biological Approach (den Boer J A and Ad Sitsen, J M, eds.), Marcel Dekker, New York, pp 497–514
van der Heyden, J. A, Molewijk, E., and Oliver, B (1987) Strain differences in response to drugs in the tail suspension test for antidepressant activity Psychopharmacology 92, 127–130
van Hest, A., van Dnmmelen, M, and Olivier, B (1992) Flesinoxan shows anti depressant activity in a DRL 72-s screen Psychopharmacology 107, 474–479
van Riezen, H., Schmeden, H, and Wren, A.F. (1977) Olfactory bulb ablation in the rat. behavioural changes and their reversal by antidepressant drugs. Br J Pharmacol 60, 521–528
Vaugeois J M, Pouhe, D, Zuccaro, F., and Costentin, J. (1996) Indirect dopam ine agonists effects on despair test dissociation from hyperactivity Pharmacol Biochem Behav 54, 235–239
Wainstein, M, Tannhauser, M, and Barros, H. M. (1990) Lack of tolerance to imipramine or miansenne in two animal models of depression. Pharmacology 41, 327–332.
Weissman, B A, Barrett, J E, Brady, L S, Witkin, J M, Mendelson, W B, Paul, S M, and Skolnick, P (1984) Behavioral and neurochemical studies on the anticonflict actions of buspirone Drug Dev Res 4, 83–93
West, A P (1990) Neurobehavioral studies of forced swimming’s the role of learning and memory in the forced swim test Prog Neuro-Psychopharmacol Biol Psychiat 14, 863–877
Wheatley, D. (1982) Buspirone multicenter efficacy study J Clin Psychiat 43, 92–94
Widgiz, S L M and Beck, C H. M (1990) The effects of diazepam on the exploratory behaviour of rats in an elevated runway Evidence for biphasic effects of benzodiazepines Behav Brain Res 40, 109–118
Willner, P. (1994) Animal models of depression, in Handbook of Depression and Anxiety. A Biological Approach (den Boer, J A and Ad Sitsen, J M, eds) Marcel Dekker, New York, pp 297–316
Willner, P, Muscat, R, and Papp, M (1992) Chronic mild stress-induced anhedonia a realistic animal model of depression Neurosci Biobehav Rev 16, 525–534
Willner, P, Towell, A, Sampson, D, Sophokleous, S, and Muscat, R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant Psychopharmacology 93, 358–364
Winslow, J T and Insel, T R (1990) Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rat pups Neuropsychopharmacology 3, 51–59
Wise, R. A, Bauco, P, Carlezon, W A, and Tromiar, W (1992) Self-stimulation and drug reward mechanisms Ann NY Acad Set 654, 192–198
Witkin, J M and Perez, L A (1990) Comparison of anticonfhct effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonergic receptors in rats Behav Pharmacol 1, 247–254
Wright, I K, Heaton, M, Upton, N, and Marsdon, C A (1992) Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the rat elevated X-maze Psychopharmacology 107, 405–414
Yamashita, S Oishi, R, and Gomita, Y (1995) Anticonfhct effects of acute and chronic treatments with buspirone and gepirone in rats Pharmacol Biochem Behav 50, 477–479
Young, R and Johnson, D N (1991a) A fully automated light/dark appara tus useful for comparing anxiolytic agents Pharmacol Biochem Behav 40, 739–743
Young, R. and Johnson, D N (1991b) Comparison of routes of administration and time course effects of zacopnde and buspirone in mice using an auto mated light/dark test Pharmacol Biochem Behav 40, 733–737
Young, R, Urbancic, A, Emrey, T A, Hall, P. C, and Metcalf, G (1987) Behav ioral effects of several anxiolytics and putative anxiolytics Eur J Pharmacol 143, 361–371
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Treit, D., Menard, J. (1998). Animal Models of Anxiety and Depression. In: In Vivo Neuromethods. Neuromethods, vol 32. Humana Press. https://doi.org/10.1385/0-89603-511-5:89
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