Abstract
Although central manipulations with electrical and chemical stimulation techniques are invaluable for investigating mechanisms of brain function, the use of this approach is often criticized for the “nonphysiological” nature of such interventions. This criticism mainly applies to the use of artificial stimuli in relation to possible “non-specific” effects. Examples of such problems are particularly salient with chemical stimulation techniques and include factors such as osmotic and pH influences, selectivity of drug action and so on. At another level it is important to recognize the fact that local brain stimuli may activate or inhibit only a segment of the mechanisms involved in the phenomenon that is studied—brain circuits do not act in isolation. These considerations may usefully be held in mind when interpreting the influences of local brain manipulations.
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References
Aghajanian, G. K. and Davis, M. (1975) A method of direct chemical brain stimulation in behavioral studies using microiontophoresis Pharmacol Biochem Behav 3, 127–131
Agnew, W F and McCreery, D B. (1990) Consideration for safety with chronically implanted nerve electrodes Epilepsia 31,Suppl 2, 27–32
Asanuma, H. and Arnold, A P. (1975) Noxious effects of excessive currents used for intracortical microstimulation. Brain Res. 96, 103–107
Azami, J, Llewlyn, M B, and Roberta, M H T (1980) An extra-fine assembly for intracerebral microinjection J Physiol (Lond.), 305, 18P–19P
Bielajew, C. and Shizgal, P. (1982) Behaviourally derived measures of conduction velocity in the substrate for rewarding medial forebrain bundle stimulation Brain Res 237, 107–119
Blair, R, Fishman, B., Amit, Z., and Weeks, J R (1980) A simple double channel swivel for infusions of fluids into unrestrained animals Pharmacol Biochem Behav 12, 463–466
Bozarth, M A and Wise, R A (1980) Electrolytic microinfusion transducer. An alternative method of intracranial drug application J Neurosa Methods 2, 273–275.
Bureš J, Buresová O, and Huston, J P (1983) Techniques and Basic Experiments for the Study of Brain Behaviour, Elsevier, Amsterdam
Carlezon, W A Jr and Wise, R. A. (1996) Rewarding actions of phencychdine and related drugs in nucleus accumbens shell and frontal cortex. J Neurosci 16, 3112–3122
Cooley, R K and Vanderwolf C H. (1978) Stereotaxic Surgery in the Rat-A Photographic Series A. J. Kirby, London, Ontario, Canada.
Cnswell, H E (1977) A simple chronic microinjection system for use with chemitrodes Pharmacol Biochem Behav 6, 237–238
Fletcher, P J and Paterson, I A (1989) Acompanson of effects of tryptamine and 5-hydroxytryptamine on feeding following injection into the paraventricular nucleus of the hypothalamus Pharmacol Biochem Behav 32, 907–911
Fritsch, G and Hitzig, E (1870) Uber die elektrische Erragbarkeit des Grosshirns Arch Anat Physiol 37, 330–332
Franklin, K and Paxmos, G (1997) The Mouse Brain in Stereotaxic Coordinates Academic, San Diego, CA
Gallistel, C R Rolls, E T, and Greene, D (1969) Neuron function inferred from behavioral and electrophysiological estimates of refractory period Science 166, 1028–1030
Greenshaw, A J (1997) A simple technique for determining stereotaxic coordinates for brain implantation of probes at rotated angles in one or two planes J Neurosci Meth (in press)
Hashimoto, M (1915a) Fieberstudien I Mitteilung Uber die spezifische Uberempfindhchkeit des Warmzentrums an sensibihsierten tieren Arch Exper Pathol Pharmakol 70, 370–393
Hashimoto, M (1915b) Fieberstudien II Mitteilung Uber den Einfluss unmitelbaver Erwarmung und Abkuhlung des Warmzentrums auf die Tenperaturwirkungen von verschiedenen pyrogenene und antiphyretischen Substanzen Arch Exper Pathol Pharmakol 70, 394–425
Hess, W R (1928) Hirnreizversuche uber den mechanisms des schlafes Arch Psychiatr. 86, 287–292
Ireland, W P (1988) Mathematical means to allow computer calculation of stereotaxic settings J Neurosci Meth 23, 85–89
Iwamoto, E T, Williamson, E C, Wash, C, and Hancock, R (1984) An improved infusion pump for injecting nanohter volumes subcortically in awake rats Pharmacol Biochem Behav 20, 959–963
Kandel, E R, Schwartz, J H, and Jessell, T M (1991) Principles of Neural Science Appleton and Lange, East Norwalk, Conn
Miliaressis, E (1981) A miniature moveable electrode for brain stimulation in small animals Brain Res Bull 7, 715–718
Myers, R. D. (1974) Handbook of Drug and Chemical Stimulation of the Brain Van Nostrand Rheinold, New York.
Nicholls, J G, Martin, A R, and Wallace, B G (1992) From Neuron To Brain A Cellular and Molecular Approach to the Function of the Nervous System, 3rd ed, Sinauer Associates, Sunderland, MA
Paxinos, G. and Watson, C. (1997) The Rat Brain in Stereotaxic Coordinates Compact 3rd ed, Academic Press, San Diego
Parada, M A Puig de Parada, M, and Hoebel, B. G (1994) A new triple channel swivel for fluid delivery m the range of intracranial (10 nl) and intravenous (100 µ1) self-administration volumes and also suitable for microdialysis J Neurosci Meth 54, 1–8
Ranck, J B Jr (1975) Which elements are excited in electrical stimulation of mammalian central nervous system? Brain Res 98, 417–440
Ranck, J. B. Jr. (1981) Extracellular stimulation, in Electrical Stimulation Research Techniques (Patterson, M M and Kesner, R P., eds ) Academic, New York, pp 1–36
Simonoff, L N (1866) Die hemmungs mechanismen der Sangethiere experimentell bemeisen. Arch Anat. Physiol Leipzig, 33, 545–565
Tehovnik, E J (1996) Electrical stimulation of neural tissue to evoke behavioural responses J Neurosci Meth 65, 1–17.
Urquhart J Fara J. W. and Willis K L (1984) Rate-controleed delivery systems in drug and hormone research. Ann Rev Pharmacol Toxicol 24, 199–236
von Euler, C and Holmgren, B. (1956) The “thyroxine” receptor of the thyroidpituitary system J Physiol (Lond.) 131, 125–136
Walls, E K and Wishart, T B (1977) Reliable method for cannulation of the third venhcle of the rat Physiol Behav 19, 171–173
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Greenshaw, A.J. (1998). Electrical and Chemical Stimulation of Brain Tissue in Vivo. In: In Vivo Neuromethods. Neuromethods, vol 32. Humana Press. https://doi.org/10.1385/0-89603-511-5:359
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DOI: https://doi.org/10.1385/0-89603-511-5:359
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