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Antisense Oligodeoxynucleotide Technology

Application to CNS Neuropharmacology

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In Vivo Neuromethods

Part of the book series: Neuromethods ((NM,volume 32))

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Abstract

With the advent of molecular cloning techniques in the past decade, a large number of novel gene products with unknown functions have been identified in the brain. For instance, an explosive growth has occurred in the discovery of many new receptor subtypes or receptors for most neurotransmitters. However, the lack of truly selective ligands for each of these new receptors makes it impossible to investigate their functional roles. Establishing the precise function of the newly identified receptors is an essential step for the understanding of their cellular mechanisms which may be pivotal in important neurophysiological processes and may lead to understanding of neurological or psychiatric diseases and/or their treatement.

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Authors and Affiliations

  1. Center for Molecular and Behavioral Neuroscience, The State University of New Jersey, Newark, NJ

    Abdel-Mouttalib Ouagazzal, James M. Tepper & Ian Creese

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  1. Abdel-Mouttalib Ouagazzal
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  2. James M. Tepper
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  3. Ian Creese
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© 1998 Humana Press Inc.

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Ouagazzal, AM., Tepper, J.M., Creese, I. (1998). Antisense Oligodeoxynucleotide Technology. In: In Vivo Neuromethods. Neuromethods, vol 32. Humana Press. https://doi.org/10.1385/0-89603-511-5:295

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  • DOI: https://doi.org/10.1385/0-89603-511-5:295

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-511-9

  • Online ISBN: 978-1-59259-637-9

  • eBook Packages: Springer Protocols

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