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G Protein α- and βγ-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interactions

  • Protocol
G Protein Methods and Protocols

Part of the book series: Neuromethods ((NM,volume 31))

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Abstract

Dopamine receptors are members of a large family of neurotransmitter/hormone receptors that exert their biological actions via signal transduction pathways that involve subtype-specific guanine nucleotide binding or G proteins (see Kaziro et al., 1991; Simon et al., 1991; Hille, 1992; Iyengar, 1993; Clapham and Neer, 1993; Gilman, 1995; Rodbell, 1995; Raymond, 1995). On the basis of biochemical, pharmacological and physiological criteria, receptors for dopamine within the central nervous system and periphery have been classified into two types, termed Dl and D2 (see reviews: Kebabian and Calne, 1979; Seeman, 1980; Niznik, 1987; Niznik and Jarvie 1989; Niznik and Van Tol, 1992; Kebabian, 1993; Hall, 1994; Lokhandwala and Chen, 1994). Operationally, native membrane-bound dopamine Dl receptors are defined by their ability to stimulate, via Gs or Golf (Herve et al., 1993), adenylate cyclase activity which subsequently activates cAMP-dependent protein kinases (see Hemmings et al., 1987; Lovenberg et al., 1991; Niznik et al, 1992).

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Authors and Affiliations

  1. Clarke Institute of Psychiatry, University of Toronto, Ontario, Canada

    Zdenek B. Pristupa & Hyman B. Niznik

  2. Department of Pharmacology, University of Texas South Western Medical Center, Dallas, TX

    Roger K. Sunahara

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  1. Zdenek B. Pristupa
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  2. Roger K. Sunahara
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  3. Hyman B. Niznik
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Editor information

Editors and Affiliations

  1. McMaster University, Hamilton, Canada

    Ram K. Mishra

  2. University of Alberta, Edmonton, Canada

    Glen B. Baker

  3. University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

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© 1997 Humana Press Inc

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Pristupa, Z.B., Sunahara, R.K., Niznik, H.B. (1997). G Protein α- and βγ-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interactions. In: Mishra, R.K., Baker, G.B., Boulton, A.A. (eds) G Protein Methods and Protocols. Neuromethods, vol 31. Humana Press. https://doi.org/10.1385/0-89603-490-9:81

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  • DOI: https://doi.org/10.1385/0-89603-490-9:81

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-490-7

  • Online ISBN: 978-1-59259-636-2

  • eBook Packages: Springer Protocols

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