G Protein α- and βγ-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interactions

  • Zdenek B. Pristupa
  • Roger K. Sunahara
  • Hyman B. Niznik
Part of the Neuromethods book series (NM, volume 31)


Dopamine receptors are members of a large family of neurotransmitter/hormone receptors that exert their biological actions via signal transduction pathways that involve subtype-specific guanine nucleotide binding or G proteins (see Kaziro et al., 1991; Simon et al., 1991; Hille, 1992; Iyengar, 1993; Clapham and Neer, 1993; Gilman, 1995; Rodbell, 1995; Raymond, 1995). On the basis of biochemical, pharmacological and physiological criteria, receptors for dopamine within the central nervous system and periphery have been classified into two types, termed Dl and D2 (see reviews: Kebabian and Calne, 1979; Seeman, 1980; Niznik, 1987; Niznik and Jarvie 1989; Niznik and Van Tol, 1992; Kebabian, 1993; Hall, 1994; Lokhandwala and Chen, 1994). Operationally, native membrane-bound dopamine Dl receptors are defined by their ability to stimulate, via Gs or Golf (Herve et al., 1993), adenylate cyclase activity which subsequently activates cAMP-dependent protein kinases (see Hemmings et al., 1987; Lovenberg et al., 1991; Niznik et al, 1992).


Dopamine Receptor Cytoplasmic Loop Dopamine Receptor Subtype Raclopride Binding Striatal Interneuron 
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Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  • Zdenek B. Pristupa
    • 1
  • Roger K. Sunahara
    • 2
  • Hyman B. Niznik
    • 1
  1. 1.Clarke Institute of PsychiatryUniversity of TorontoOntarioCanada
  2. 2.Department of PharmacologyUniversity of Texas South Western Medical CenterDallas

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