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G Protein-Coupled melatonin receptors

  • Protocol
G Protein Methods and Protocols

Part of the book series: Neuromethods ((NM,volume 31))

Abstract

Increasing evidence indicates that melatonin, the principal hormone secreted by the pineal gland, influences the function of diverse neuroendocrine and other systems in mammals. This indoleamine hormone is also involved in maintaining brain homeostasis, entraining biological rhythms and coordinating reproductive function to changes in photoperiod, particularly in seasonal breeders (Brown, and Niles, 1982; Tamarkin et al, 1985; Reiter, 1991). Other studies indicate a potentially important immunomodulatory role for melatonin (Maestroni, 1993) that binds with high affinity to T-lymphocytes (Gonzalez-Haba et al., 1995). Recent reports that melatonin is a potent free radical scavenger suggest that it may also play an important role as a protective antioxidant hormone (Hardeland et al., 1993; Reiter, 1996).

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Authors and Affiliations

  1. Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

    Lennard P. Niles

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  1. Lennard P. Niles
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Editors and Affiliations

  1. McMaster University, Hamilton, Canada

    Ram K. Mishra

  2. University of Alberta, Edmonton, Canada

    Glen B. Baker

  3. University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

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© 1997 Humana Press Inc

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Niles, L.P. (1997). G Protein-Coupled melatonin receptors. In: Mishra, R.K., Baker, G.B., Boulton, A.A. (eds) G Protein Methods and Protocols. Neuromethods, vol 31. Humana Press. https://doi.org/10.1385/0-89603-490-9:223

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  • DOI: https://doi.org/10.1385/0-89603-490-9:223

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-490-7

  • Online ISBN: 978-1-59259-636-2

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