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G Proteins and Mood Disorders

  • Jun-Feng Wang
  • L. Trevor Young
Part of the Neuromethods book series (NM, volume 31)

Abstract

A neurobiological basis for mood disorders has long been postulated, but is yet to be conclusively established. Earlier studies on the monoaminergic neurotransmitter systems in mood disorder have been very suggestive, although not conclusive, of alterations in these systems (noradrenergic, dopaminergic, serotonergic, and cholinergic) possibly owing to changes in receptor sensitivity (Post and Ballenger, 1984). These data have resulted in a recent and relatively extensive field of research investigating mechanisms that regulate receptor responsivity, which has focused to a large extent on the G protein-coupled signal transduction pathways.

Keywords

Bipolar Disorder Major Depressive Disorder Mood Disorder Adenylyl Cyclase Antidepressant Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Avissar, S and Schreiber, G. (1989) Muscarinic receptor subclassification and G proteins: Significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics Biol. Psychiatry 26, 113–130.PubMedGoogle Scholar
  2. Avissar, S. and Schreiber, G. (1992) The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders. Biol Psychiatry 31, 435–459PubMedGoogle Scholar
  3. Avissar, S., Schreiber G, Danon, A., and Balmaker, R H (1988) Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex Nature 331, 440–442PubMedGoogle Scholar
  4. Avissar, S., Schreiber, G, Aulakh, C. S, Wozniak, K. M., and Murphy, D. L. (1990) Carbamazepine and electroconvulsive shock attenuate β-adrenoceptor and muacarinic cholinoceptor coupling to G proteins in rat cortex Eur J. Pharmacol. 189, 99–103.PubMedGoogle Scholar
  5. Avissar, S., Murphy, D. L., and Schreiber, G. (1991) Magnesium reversal of lithium inhibition of β adrenergic and muscarinic receptor coupling to G proteins. Biochem. Pharmacol 41, 171–175PubMedGoogle Scholar
  6. Avissar, S., Barki-Harrington, L., Nechamkin, Y, Roitman, G, (1996) Reduced β-adrenergic receptor-coupled Gs protein function and Gs immunoreactivity in mononuclear leukocytes of patients with depression. Biol. Psychiatry 39, 755–760.PubMedGoogle Scholar
  7. Backlund, P. S. Jr, Simonds, W. E., and Spiegel, A. M. (1990) Carboxyl methylation and COOH-terminal processing of the brain G protein gamma-subunit. J iol. Chem 265, 15,572–15,576.Google Scholar
  8. Banerjee, S. P., Kung, S L, Riggi, S. J., and Chanda, S. (1977) Development of β-adrenergic receptor subsensitivity by antidepressants Nature 268, 455, 456.PubMedGoogle Scholar
  9. Barnard, E. A(1988) Molecular neurobiology separating receptor subtypes from their shadows. Nature 335, 301–302.PubMedGoogle Scholar
  10. Bergstrom, D A and Kellar, K J. (1979) Effect of electroconvulsive shock therapy on monoaminergic receptor binding sites in rat brain. Nature 278, 464–466PubMedGoogle Scholar
  11. Birnbaumer, L. (1993) Receptor-to-effector signaling through G proteins, roles for beta gamma dimers as well as alpha subunits Cell 71, 1069–1072.Google Scholar
  12. Birnbaumer, L., Abramowitz, J, and Brown, A M(1990) Receptor-effector coupling by G proteins. Biochem Biophys Acta 1031, 163–224PubMedGoogle Scholar
  13. Bunney, W. E., Jr. and Garland-Bunney, B. L. (1987) Mechanisms of action of lithium in affective illness, basic and clinical implications, in Psychopharmacology The Third Generation of Progress (Meltzer, H Y., ed.), Raven, New York, pp. 553–565Google Scholar
  14. Carli, M., Anand-Srivastava, M., Molina-Holgado, E, Dewar, K. M., and Reader T A. (1994) Effects of chronic lithium treatments on central dopaminergic receptor systems. G proteins as possible targets. Neurochem. Int 24, 13–22.PubMedGoogle Scholar
  15. Chen, J. and Rasenick, M. M. (1995a) Chronic treatment of C6 glioma cell with antidepressant increases functional coupling between a G protein (Gs) and adenylyl cyclase. J Neurochem 64, 724–732PubMedGoogle Scholar
  16. Chen, J. and Rasenick, M. M (1995b) Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content. J. Pharmacol Exp Ther. 275, 509–517.PubMedGoogle Scholar
  17. Clapham, D E and Neer, E. J (1993) New roles for G protein βγ dimers in transmembrane signaling. Nature 365, 403–406.PubMedGoogle Scholar
  18. Cockcroft, S. and Gomperts, D (1985) Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodi-esterase Nature 314, 534–536.PubMedGoogle Scholar
  19. Colin, S. F., Chang, H.-C, Mollner, S., Pfeuffer, T., Reed, R. R., Duman, R S., and Nestler, E. J. (1991) Chronic lithium regulates the expression of adenylate cyclase and Gi-protein α-subunit in rat cerebral cortex. Proc Natl. Acad Sci USA 88, 10,634–10,637PubMedGoogle Scholar
  20. Coppen, A (1967) The biochemistry of affective disorders. Br. J Psychiatry 113, 1237–1264.PubMedGoogle Scholar
  21. Cowburn, R. F., Marcusson, J. O., Eriksson, A., and O’Neill, C.,(1994) Adenylyl cyclase activity and G protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res. 633, 297–304PubMedGoogle Scholar
  22. Crespo, P., Xu, N., Simonds, W E, and Gutking, J S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G protein βγ-subunits. Nature 369, 418–420.PubMedGoogle Scholar
  23. Emamghoreishi, M., Warsh, J. J., Sibony, D., and Li, P. P. (1996) Lack of effect of chronic antidepressant treatment on Gαs and Gα1 subunit protein and mRNA levels in the rat cerebral cortex. Neuropsychophar-macoiogy 15, 281–287.Google Scholar
  24. Extein, I, Tallman, J., Smith, C. C., and Goodwin, F. K. (1979) Changes in lymphocyte beta-adrenergic receptors in depression and mania. Psychiatry Res. 1, 191–197.PubMedGoogle Scholar
  25. Faure, M., Voyno-Yasenetskaya, A., and Bourne, H. R. (1994) cAMP and βγ-subunits of heterotrimeric G proteins stimulate the mitogen-acti-vated protein kinase pathway in COS-7 cells. J Biol. Chem 169, 7851–7854.Google Scholar
  26. Federman, A. D, Conklin, B. R, Schrader, K. A., Reed, R. R., and Bourne, H R. (1992) Hormonal stimulation of adenlyl cyclase through Gi-protein beta gamma subunits. Nature 356, 159–161.PubMedGoogle Scholar
  27. Forn, J. and Valdecasas, F. G. (1971) Effects of lithium on brain adenyl cyclase activity. Biochem. Pharmacol. 20, 2773–2779PubMedGoogle Scholar
  28. Gejman, P. V., Martinez, M., Cao, Q. H., Friedman, E., Berrettim, W. H., Goldin, L. R, Koroulakis, P., Ames, C., Lerman, M. A., and Gershon, E. S. (1993) Linkage analysis of 57 microsatellite loci to bipolar disorder. Neuropsychopharmacology 9, 31–40.PubMedGoogle Scholar
  29. Gil, D. W. and Wolfe, B. B. (1985) Pirenzepine distiguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase J. Pharmacol. Exp. Ther. 232, 608–616.PubMedGoogle Scholar
  30. Gilman, A. G. (1987) G proteins-transducers of receptor-generated signals. Annu. Rev. Biochem. 56, 615–649.PubMedGoogle Scholar
  31. Goldberg, H., Clayman, P., and Skorecki, K. (1988) Mechanism of Li inhibition of vasopressm-sensitive adenylate cyclase in cultured renal epithelial cells. Am. J. Phystol. 255, F995–F1002.Google Scholar
  32. Halper, J. P, Brown, R. P., Sweeney, J. A., Kocsis, J. H., Peters, A., and Mann, J. J. (1988) Blunted β-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Arch Gen. Psychiatry. 45, 241–244.PubMedGoogle Scholar
  33. Hammer, R and Giachetti, A. (1982) Muscarinic receptor subtypes: M1 and M2, biochemical and functional characterization. Life Sci. 2991–2998.Google Scholar
  34. Heal, K. J, Butler, S A., Hurst, E. M., and Buckett, W. R. (1989) Antidepressant treatments including sibutramine hydrochloride and electroconvulsive shock, decrease β1 and β2-adrenoceptors in rat cortex J. Neurochem. 53, 1019–1025PubMedGoogle Scholar
  35. Hepler, J. R. and Gilman, A G. (1992) G proteins. Trends Biochem. Sci 17, 383–387.PubMedGoogle Scholar
  36. Hsiao, J. K., Manji, H. K, Chen, G., Bitran, J. A, Risby, E. D., and Potter, W Z (1992) Lithium administration modulates platelet G1 in humans Life Sci 50, 227–233.PubMedGoogle Scholar
  37. Hudson, J., Young, L. T., Li, P P, and Warsh, J. J (1996) CNS transmembrane signal transduction in the pathophysiology and pharmacology of affective disorders and schizophrenia. Synapse 13, 278–293.Google Scholar
  38. Iyengar, R. (1993) Molecular and functional diversity of mammalian G5-stimulated adenylyl cyclasesFASEB J. 7, 768–775PubMedGoogle Scholar
  39. Jope, R. S., Song, L., Li, P. P., Young, L. T., Kish, S J., Pacheco, M A., and Warsh, J. J. (1996) The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain J. Neurochem 66, 2402–2409PubMedGoogle Scholar
  40. Kay, G., Sargeant, M, McGuffin, P, Whatley, S, Marchbanks, R., Baldwin, D., Montgomery, S., and Elliott, J. M. (1993) The lymphoblast β-adrenergic receptor in bipolar depressed patients characterization and down-regulation. J. Affect Disord 27, 163–172PubMedGoogle Scholar
  41. Kellar, K. J., Cascio, S., Butler, J. A, and Kurtzke, R. N. (1981) Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain. Eur. J. Pharmacol. 69, 515–518.PubMedGoogle Scholar
  42. Landmann, R., Burgisser, E., and Buhler, F. R. (1983) Human lymphocytes as a model for beta-adrenergic receptors in clinical investigation J. Receptor Res. 3, 71–88.Google Scholar
  43. Le, F., Mitchell, P, Vivero Waters, Donald, J, Selbie, L A., Shine, J, and Schofield, P (1994) Exclusion of close linkage of bipolar disorder to the Gs-a-subunit gene in nine Australian pedigrees. J. Affec. Dis. 32, 187–195.Google Scholar
  44. Lesch, K, Aulakh,, Tolliver, T., Hill, J, and Woldzin, B. (1991a) Differential effects of long-term lithium and carbamazepine administration on Gs and G1 protein in rat brain. J. Pharmacol Mol Pharmacol 207, 355–359Google Scholar
  45. Lesch, K., Aulakh, C, Tolhver, T, Hill, J, and Murphy, D (1991b) Regulation of G proteins by chronic antidepressant drug treatment in rat bram: tricyclics but not clorgyline increase Gαo subunits Eur J Pharmacol 207, 361–364.PubMedGoogle Scholar
  46. Li, P P, Young, L. T., and Warsh, J. J. (1991) Lithium decreased Gs, Gi-l and Gi-2 α-subunit mRNA levels in rat cortex. Eur J. Pharmacol. Mol Pharmacol. 206, 165, 166.Google Scholar
  47. Li, P. P, Young, L T, Y Tam, D. Sibony, and J. J Warsh. (1993a) Effects of chronic lithium and carbamazepine treatment on G protein subunit expressioninrat cerebral cortex. Biol Psychiatry 34, 167–170Google Scholar
  48. Li, X. and Jope, R. S(1995) Selective inhibition of the expression of signal transduction proteins by lithium in nerve growth factor-differentiated PC12 cells J. Neurochem 65, 2500–2508PubMedGoogle Scholar
  49. Logothetis, D. E., Kurachi, Y, Galper, J., Neer, E. J, and Clapham, D. E. (1987) The βγ-subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 325, 321PubMedGoogle Scholar
  50. Manji, H, Chen, G, Shimon, H., Hsiao, J. K, Potter, W. Z., and Belmaker, R. H. (1995a) Guanine nucleotide-binding proteins in bipolar affective disorder Arch. Gen. Psychiatry 52, 135–144.PubMedGoogle Scholar
  51. Mann, J. J., Brown, R P., Halper, J P., Sweeney, J. A., Kocsis, J. H, Stokes, P. E, and Bilezikian, J. P. (1985) Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. N. Engl. J. Med. 313, 715–720PubMedGoogle Scholar
  52. Masana, M I., Bitran, J. A., Hsiao, J. K., Mefford, I. N., and W. Z. Potter. (1991) Lithium effects on noradrenergic-linked adenylate cyclase activity in intact rat brain and in vivo microdialysis study. Brain Res 538, 333–336PubMedGoogle Scholar
  53. Masana, M I., Bitran, J. A., Hsiao, J. K., and Potter, W Z. (1992) In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain. J. Neurochem. 59, 200–205.PubMedGoogle Scholar
  54. Mathews, R, Li, P. P, Young, L T, Kish, S. J, and Warsh, J. J (1997) Increased Gq/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder Biol. Psychiatry, 41, 649–656PubMedGoogle Scholar
  55. Menkes, D., Rasenick, M. M, Wheeler, M. A., and Bitensky, M. W. (1983) Guanosine triphosphate activation of brain adenylate cyclase enhancement by long-term antidepressant treatment. Science 219, 65–67PubMedGoogle Scholar
  56. Milligan, G (1993) Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications Trends Pharmacol Sci. 14, 413–416.PubMedGoogle Scholar
  57. Milligan, G., Unson, G, and Wakelam, M J. O. (1989) Cholera toxin treatment produces down-regulation of the-subunit of the stimulatory guanine-nucleotide-binding protein (Gs). Biochem. J 262, 643–647.PubMedGoogle Scholar
  58. Mishra, R, Janowsky, A., and Sulser, F. (1980) Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain, subsensitivity without reduction in β-adrenergic receptor binding. Neuropharrnacology 19, 983–987.Google Scholar
  59. Mork, A. and Geisler, A. (1989a) Effects of lithium ex vivo on the GTP-mediated inhibition of calcium-stimulated adenylate cyclase activity in rat brain. Eur. J. Pharmacol. 168, 347–354, 1989.PubMedGoogle Scholar
  60. Mork, A. and Geisler, A. (1989b) Effects of GTP on hormone-stimulated adenylate cyclase activity in cerebral cortex, striatum, and hippocampus from rats treated chronically with lithium. Biol Psychiatry 26, 279–288.PubMedGoogle Scholar
  61. Moss, J. and Vaughan, M. (1988) ADP-ribosylation of guanyl mucleotide-bindmg regulatory proteins by bacterial toxins. Adv. Enzymol 60, 303–379.Google Scholar
  62. Muller, W., Brunner, H., and Misgeld, U (1989) Lithium discriminates between muscarinic receptor subtypes on guinea pig hippocampal neurons in vitro Neurosci. Lett 100, 135–140.PubMedGoogle Scholar
  63. Nathanson, N.in, Klein, W. L., and Nireneberg, M. (1978) Regulation of adenylate cyclase activity mediated by muscarinic acetylcholine receptor Proc. Natl Acad. Sci USA 75, 1788–1791PubMedGoogle Scholar
  64. Neer, E J. (1995) Heterotrimeric G proteins Organizers of transmembrane signals. Cell 80, 249–257.PubMedGoogle Scholar
  65. Nestler, E. J., Terwilliger, R. Z., and Duman, R. S (1995) Regulation of endogenous ADP-ribosylation by acute and chronic lithium in rat brain. J Neurochem. 64, 2319–2324.PubMedGoogle Scholar
  66. Newman, M E and Lerer, B. (1989) Post-receptor-mediated increases in adenylate cyclase activity after chronic antidepressant treatment relationship to receptor desensitisation Eur. J. Pharmacol 162, 345–352.PubMedGoogle Scholar
  67. Newman, M. E., Solomon, H., and Lerer, B. (1986) Electroconvulsive shock and cyclic AMP signal transduction effects distal to the receptor. J Neurochem. 46, 1667–1669PubMedGoogle Scholar
  68. Newman, M E., Lipot, M., and (1987) Differential effects of chronic administration of desipramine on the cyclic AMP response in cortical slices and membranes in the rat. Neuropharmacology 26, 1127–1130.PubMedGoogle Scholar
  69. Newman, M. E, Drummer, D., and (1989) Single and combined effects of desimipramine and lithium on serotonergic receptor number and second messenger function in rat brain J Pharmacol Exp. Ther 252, 826–831Google Scholar
  70. Newman, M. E., Ben-Zeev, A., and Lerer, B. (1991) Chloramphetamine did not prevent the effects of chronic antidepressants on 5-hydroxy-tryptamine inhibition of forskolin-stimulated adenylate cyclase in rat hippocampus Eur. J Pharmacol 207, 209–213PubMedGoogle Scholar
  71. Odagaki, Y, Koyama, Y, and Yamashita, I. (1992) Lithium and serotonergic neural transmission, a review of pharmacological and biochemical aspects in animal studies. Lithium 3, 95–107.Google Scholar
  72. Ozawa, H. and Rasenick, M. M (1989) Coupling of the stimulatory GTP-binding protein Gs to rat synaptic membrane adenylate cyclase in enhanced subsequent to chronic antidepressant treatment. Mol Pharmacol. 36, 803–808PubMedGoogle Scholar
  73. Ozawa, H. and Rasenick, M. M. (1991) Chronic electroconvulsive treatment augments coupling of the GTP-bindmg protein Gs to the catalytic moiety of adenlyl cyclase in a manner similar to that seen with chronic antidepressant drugs. J Neurochem 66, 330–338.Google Scholar
  74. Ozawa, H., Gsell, W., Frolich, L., Zochling, R., Pantucek, F., Beckmann, H., and Riederer, P. (1993) Imbalance of the Gs and Gi/o function in postmortem human brain of depressed patients. J. Neural. Transm. (Gen Section) 94, 63–69Google Scholar
  75. Ozawa, H., Katamura, Y., Hatta, S, Amemiya, N., Saito, T., Ohshika, H., and Takahata, N (1994) Antidepressants directly influence in situ binding of guanine nucleotide in synaptic membrane. Life Sci 54, 925–932.PubMedGoogle Scholar
  76. Pandey, G. N., Dysken, M. W, Garver, D. L., and Davis, J. M. (1979a) Changes in lymphocyte beta-adrenergic receptor function in affective illness. Am J Psychiatry 136, 675–678.PubMedGoogle Scholar
  77. Pandey, G N, Heinze, W J, Brown, B. D., and Davies, J M. (1979b) Electroconvulsive shock treatment decreases β-adrenergic receptor sensitivity in rat brain. Nature 280, 234,235.Google Scholar
  78. Peralta, E. G., Ashkenazi, A., Winslow, J. W., Ramachandran, J, and Capon, D. J. (1988) Differential regulation of PI hydrolysis and adenyl cyclase by muscarinic receptor subtypes. Nature 334, 434–437PubMedGoogle Scholar
  79. Post, R and Ballenger, J. (1984) Neurobiology of Mood Disorders. Williams & Wilkins, Baltimore, p. 887Google Scholar
  80. Price, L. H, Charney, D. S., Delgado, P. L., and Heninger, D. R (1990) Lithium and serotonin function, implications for the serotonin hypothesis of depression Psychopharmacology 100, 3–12.PubMedGoogle Scholar
  81. Raymond, J. R(1995) Multiple mechanisms of receptor-G protein signaling specifity Am. J. Phystol 38, F141–F158.Google Scholar
  82. Rens-Domiano, S. and Hamm, H. (1995) Structural and functional relationships of heterotrimeric G proteins. FASEB. J. 9, 1059–1066.PubMedGoogle Scholar
  83. Reuveny, E., Slesinger, P A., Inglese, J., Morales, J. M., Iniguez-Lluhi, J. A., Lefkowitz, R. J., Bourne, H. R., Jan, Y. N., and Jan, L. Y(1994) Activation of the cloned muscarinic potassium channel by G protein βγ-subunits. Nature 370, 143–146.PubMedGoogle Scholar
  84. Risby, E. D., Hsiao, J K., and Manji, H. K. (1991) The mechanisms of action of lithium. II. Effects on adenylate cyclase activity and β-adrenergic receptor binding in normal subjects. Arch. Gen. Psychiatry 48, 513–524.PubMedGoogle Scholar
  85. Schildkraut, J. J (1965) The catecholamine hypothesis of affective disorders A review of supporting evidence. Am. J. Psychiatry 122, 509–522.PubMedGoogle Scholar
  86. Schreiber, G, S. Avissar, A Danon, and R. H. Belmaker. (1991) Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry 29, 273–280.PubMedGoogle Scholar
  87. Shelton, R., Manier, M. S, and Sulser, F. (1996) cAMP dependent protein kinase activity in major depression. Am. J. Psychiatry 153, 1037–1042PubMedGoogle Scholar
  88. Siever, L. J, Kafka, M. S., Targum, S., and Lake, R. (1984) Platelet alpha-adrenergic binding and biochemical responsiveness in depressed patients and controls. Psychiatry Res. 11, 287–302.PubMedGoogle Scholar
  89. Smrcka, A. V and Sternweis, P. C. (1994) Regulation of purified subtypes of phosphatidylinositol-specific phospholipase Cβ by G protein α-and βγ-subunits. J. Biol Chem. 268, 9667–9674.Google Scholar
  90. Spiegel, A M., Shenker, A., and Weinstein, L. S (1992) Receptor-effector coupling by G proteins: Implications for normal and abnormal signal transduction. Endocnnol Rev. 13, 536–565Google Scholar
  91. Tamir, A. and Gill, D M. (1988) ADP-ribosylation by chlera toxin of membranes derived from brain modifies the interaction of adenylate cyclase with guanine nucleotides and NaF J. Neurochem. 50, 1791–1797.PubMedGoogle Scholar
  92. Vetulani, J. and Susler, F. (1975) Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP generation in limbic forebrain. Nature 247, 495,496Google Scholar
  93. Vetulani, J., Stawarz, R. J, Dingell, J. V., and Susler, F. (1976) A possible common mechanism of action of antidepressant treatments. Naunyn-Schmiedeberg’s. Arch. Pharmacol. 293, 109–114.Google Scholar
  94. Vetulani, J., Lebrecht, U., and Pilc A. (1981) Enhancement of responsiveness of the central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment. Eur J. Pharmacol. 76, 81–85PubMedGoogle Scholar
  95. Volonte, C., (1987) Lithium stimulates the binding of GTP to the membranes of PC12 cells cultured with nerve growth factor. Neurosci. Lett 87, 127–132.Google Scholar
  96. Wickman, K. D., Iniguez-Lluhi, J. A, Davenport, P A., Taussig, R., Krapivinsky, G., binder, M E., Gilman, A. G., and Clapham, D. E (1994) Recombinant G protein βγ-subunits activate the muscarinicgated atrial potassium channel. Nature 368, 255–257PubMedGoogle Scholar
  97. Wood, A J. and Goodwin, G M. (1987) A review of the biochemical and neuropharmacological actions of lithium. Psychol. Med 17, 579–600PubMedGoogle Scholar
  98. Yamamoto, H., Tomita, U., Mikuni, M, Kobayashi, I., Kagaya, A., Katada, T, Ui, M, and Takahashi, K. (1992) Direct activation of purified Go-type GTP binding protein by tricyclic antidepressants. Neurosci Let 139, 194–196.Google Scholar
  99. Young, L T. and Woods, C. M (1996) Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells. Eur. J Pharmacol, in press.Google Scholar
  100. Young, L T., Li, P. P, Kish, S. J., Siu, L. P, Kamble, A., Hornykiewcz, O., and Warsh, J. J (1991) Cerebral cortex Gαs protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder J Neurochem 61, 890–898.Google Scholar
  101. Young, L. T, Li, P. P, Kish, S J., Siu, L. P., and Warsh, J J (1993) Postmortem cerebral cortex Gs alpha-subunit levels are elevated in bipolar affective disorder. Brain Res. 551, 323–326.Google Scholar
  102. Young, L T., Li, P. P., Kish, S J., and Warsh, J. J. (1994a) Cerebral cortex β-adrenoceptor binding in bipolar affective disorder. J. Affect Disord. 30, 89–92PubMedGoogle Scholar
  103. Young, L. T., Li, P P., Kamble, A, Siu, K. P., and Warsh, J. J (1994b) Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am. J. Psychiatry 151, 594–596.PubMedGoogle Scholar
  104. Young, L. T., Asghari, V., Li, P. P., Kish, S. J., Fahnestock, M., and Warsh, J J (1996) Stimulatory G protein α-subunit mRNA levels are not increased in autopsied cerebral cortex from patients with bipolar disorder Mol. Brain Res, 42, 45–50.PubMedGoogle Scholar
  105. Zemlan, F. P. and Garver, D. L. (1990) Depression and antidepressant therapy: receptor dynamics. Prog. Neuropsychopharmacol. Biol. Psychiatry 14, 503–523.PubMedGoogle Scholar

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© Humana Press Inc 1997

Authors and Affiliations

  • Jun-Feng Wang
    • 1
  • L. Trevor Young
    • 1
  1. 1.Department of Psychiatry and Biomedical SciencesMcMaster UniversityHamiltonCanada

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