The Quartz Crystal Microbalance (QCM) as an Immunosensor

  • Franz Aberl
  • Conrad Kößlinger
  • Hans Wolf
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 13)


This chapter demonstrates a preliminary experimental approach to detect antiviral antibodies by means of a quartz crystal immunosensor. As an example of the large numbers of immunoassays currently applied in the clinical laboratory, the screening for human immunodeficiency virus (HIV) specific antibodies was presented as a model application. The quartz crystal microbalance belongs to the group of acoustic immunosensors and its principle of operation is based on the propagation of acoustic shear waves in the substrate of the sensor. Phase and velocity of the acoustic wave are influenced by the specific adsorption of antibody molecules onto the antigen-coated sensor surface. This primary measuring allows the continuous monitoring of molecular interactions in liquids.


Resonant Frequency Quartz Crystal Quartz Crystal Microbalance Sensor Surface Antiviral Antibody 
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Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Franz Aberl
    • 1
  • Conrad Kößlinger
    • 1
  • Hans Wolf
    • 2
  1. 1.SecuretecMunichGermany
  2. 2.Institute for Medical Microbiology and HygieneUniversity of RegensburgGermany

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