Suppression of the Human Carcinoma Phenotype by an Antioncogene Ribozyme

  • Toshiya Shitara
  • Kevin J. Scanlon
Part of the Methods in Molecular Medicine book series (MIMM, volume 7)


A spectrum of oncogenes have been identified and are thought to be associated with the progression of neoplasia. These oncogenes include the following: growth factors/receptors, kinases, nuclear proteins (i.e., Fos/Jun), and tumor suppressor genes. Perturbation of one or more of these genes can transform normal cells into invasive/metastatic cancer cells. Understanding the role of these oncogenes for specific types of cancer may lead to a more rational basis for tissue-specific targets in cancer gene therapy.


Cancer Gene Therapy Hammerhead Ribozyme Viral Vector System Ribozyme Activity Human Bladder Carcinoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 1997

Authors and Affiliations

  • Toshiya Shitara
    • 1
  • Kevin J. Scanlon
    • 2
  1. 1.Department of UrologyKitasato University HospitalKitasatoJapan
  2. 2.City of Hope National Medical CenterDuarte

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