Abstract
If two variants in a population are related by simple Mendelian inheritance, then in principle, it is possible to isolate a gene in which the sequence differences will explain the nature of the variants. In practice, this is a daunting task in a genome the size of human (3000 Mb) and may take many years to achieve. Genome mapping and sequencing projects invert the problem by attempting the systematic discovery and ordering of all genes over a period of many years. We may reasonably expect a complete map and sequences of all the genes in the human genome (not the entire genome sequence) by about 2005.
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© 1997 Humana Press Inc., Totowa, NJ
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Bishop, M.J. (1997). Gene Mapping and Isolation. In: Boultwood, J. (eds) Gene Isolation and Mapping Protocols. Methods in Molecular Biology™, vol 68. Humana Press. https://doi.org/10.1385/0-89603-482-8:237
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DOI: https://doi.org/10.1385/0-89603-482-8:237
Publisher Name: Humana Press
Print ISBN: 978-0-89603-482-2
Online ISBN: 978-1-59259-554-9
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