Abstract
Hepatitis delta virus (HDV) is an infectious, subviral, pathogen that is associated with a high incidence of fulminant hepatitis in humans. It consists of a closed-circular, single-stranded, RNA genome of about 1700 nucleotides in length that is replicated by a rolling-circle mechanism (reviewed by refs. 1 and 2). There is no DNA intermediate. The infectious genomic strand is a template for an RNA-dependent RNA polymerase (most likely a modified activity of the host’s RNA polymerase II) that generates linear single-stranded multimers of the antigenomic sense. These linear multimers are site-specifically cleaved and ligated to form the closed-circular antigenomic RNAs, which are likewise templates for rolling-circle replication. The linear genomic multimers are also site-specifically cleaved and ligated, and the resulting circular RNAs are subsequently encapsulated to form new infectious particles.
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Tanner, N.K. (1998). Molecular Manipulations of the Catalytic RNAs from the Human Hepatitis Delta Virus. In: Scanlon, K.J. (eds) Therapeutic Applications of Ribozymes. Methods in Molecular Medicine™, vol 11. Springer, Totowa, NJ. https://doi.org/10.1385/0-89603-477-1:29
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DOI: https://doi.org/10.1385/0-89603-477-1:29
Publisher Name: Springer, Totowa, NJ
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