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Folate-Polylysine-Mediated Delivery of a Multiunit Anti-BCR/ABL Ribozyme to BCR/ABL-Transformed 32D Cells

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Therapeutic Applications of Ribozymes

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 11))

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Abstract

The use of oligodeoxynucleotides (ODN) to disrupt gene function has been studied in a variety of in vitro and in vivo systems (1–14). Antigene, antisense, ribozyme, and aptamer nucleic acid molecules have been shown in numerous model systems to effect DNA, RNA, or protein targets, or physiologic properties of cells (15). However, nucleic acid drugs must overcome several problems before wide application of these promising strategies can be realized.

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Author information

Authors and Affiliations

  1. Fels Institute for Cancer Research and Molecular Biology, Temple Cancer Center, Philaddphia, PA

    Lance H. Leopold

  2. Department of Biochemistry, Fels Institute for Molecular Biology and Cancer Research, Temple University School of Medicine, Philadelphia, PA

    Scott K. Shore, Ramana M. V. Reddy & E. Premkumar Reddy

Authors
  1. Lance H. Leopold
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  2. Scott K. Shore
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  3. Ramana M. V. Reddy
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  4. E. Premkumar Reddy
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Editors and Affiliations

  1. Berlex Biosciences, Richmond, CA

    Kevin J. Scanlon

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© 1998 Humana Press Inc.

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Leopold, L.H., Shore, S.K., Reddy, R.M.V., Reddy, E.P. (1998). Folate-Polylysine-Mediated Delivery of a Multiunit Anti-BCR/ABL Ribozyme to BCR/ABL-Transformed 32D Cells. In: Scanlon, K.J. (eds) Therapeutic Applications of Ribozymes. Methods in Molecular Medicine™, vol 11. Springer, Totowa, NJ. https://doi.org/10.1385/0-89603-477-1:279

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  • DOI: https://doi.org/10.1385/0-89603-477-1:279

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-0-89603-477-8

  • Online ISBN: 978-1-59259-595-2

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