Computer-Assisted Analysis of Single-Cell Behavior
Recent advances in analysis of signal transduction mechanisms have demonstrated that changes in cell morphology are part of cellular responses to many important stimuli. In particular, growth factors and the signaling mechanisms stimulated by them can cause dramatic reorganization of the cytoskeleton and cell shape. These changes can affect cell motility, protein synthesis, adhesion, and, potentially, gene regulation. By measuring the kinetics and characteristics of changes in cell motility, cell morphology, and subcellular structures such as vesicles and the nucleus, the relationships of these changes to other biochemical events occurring inside the cell can be better understood.
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