Inhibition of HIV Infection by Lectin Binding to CD4

  • Jean Favero
  • Virginie Lafont
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 9)


The progression of AIDS all over the world has led research laboratories to focus their energy on the identification of molecules that can impair the infection process, Every step of the viral rephcative cycle can be considered as a potential target to block infection. One of the first events in the infection of T-cells by the human immunodeficiency virus (HIV) is the binding of the viral envelope glycoprotein gp120 to the differentiation antigen CD4 expressed on the host cell (1-3). Among the therapeutic strategies aimed at controllmg HIV disease progression, one was to inhibit or perturb this interaction.


Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Jurkat Cell Human Lymphoid Cell Cathode Buffer 
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Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Jean Favero
    • 1
  • Virginie Lafont
    • 1
  1. 1.Microbiologie et Pathologie Cellulaire Infectieuse, Institut National de la Sante et de la Recherche MedicaleUniversite de Montpellier IIMontpellierFrance

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