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Inhibition of HIV Infection by Lectin Binding to CD4

  • Jean Favero
  • Virginie Lafont
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 9)

Abstract

The progression of AIDS all over the world has led research laboratories to focus their energy on the identification of molecules that can impair the infection process, Every step of the viral rephcative cycle can be considered as a potential target to block infection. One of the first events in the infection of T-cells by the human immunodeficiency virus (HIV) is the binding of the viral envelope glycoprotein gp120 to the differentiation antigen CD4 expressed on the host cell (1-3). Among the therapeutic strategies aimed at controllmg HIV disease progression, one was to inhibit or perturb this interaction.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Jurkat Cell Human Lymphoid Cell Cathode Buffer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Dalgleish, A G, Beverly, P C L., Clapham, P R., Crawford, D H, Greeves, M F, and Weiss, R A (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus Nature 312, 763–766PubMedCrossRefGoogle Scholar
  2. 2.
    Sattentau, Q J and Weiss, R A (1988) The CD4 antigen physiological ligand and HIV receptor Cell 52, 631–633PubMedCrossRefGoogle Scholar
  3. 3.
    Klatzmann, D, McDougal, J S., and Maddon, P J (1990) The CD4 molecule and HIV-1 infection Immunodeficiency Rev 2,43–66Google Scholar
  4. 4.
    Lasky, L. A, Groopman, J E, Fennie C W, Benz, P M, Capon, D J, Dowbenko, D J, Nakamura, G R., Nunes, W M, Renz, M E., and Berman, P W (1986) Neutralization of the AIDS retrovirus by antibodies to a recombmant envelope glycoprotein Science 233, 209–212PubMedCrossRefGoogle Scholar
  5. 5.
    Leonard, C K, Spellman, M W, Riddle, L, Harris, R. J, Thomas, J N, and Gregory, T. J (1990) Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.J. Biol Chem 265, 10,373–10,383PubMedGoogle Scholar
  6. 6.
    Feizr, T and Larkm, M (1990) AIDS and glycosylation. Glycobiology 1, 17–23CrossRefGoogle Scholar
  7. 7.
    Robinson, W E, Jr, Montefiort, D. C., and Mitchell, W M. (1987) Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis Aids Res Hum Retrow 3,265–282CrossRefGoogle Scholar
  8. 8.
    Fenoudlet, E, Gluckman, J C, and Barhaoui, E (1990) Role of N-linked glycans of envelope glycoproteins in infectivity of human immunodeficiency virus type 1 J. Virol 64,2841–2848Google Scholar
  9. 9.
    Duck, L, Lindemann, D, Ette, R Manzoni, C, Moritz, D, and Mous, J (1990) Mutation of conserved N-glycosylation sites around the CD4-binding site of human immunodeficiency virus type 1 gp120 affects viral infectivity Virus Res 18,9–20CrossRefGoogle Scholar
  10. 10.
    Favero, J (1994) Lectins in AIDS research Glycobiology 4, 387–396PubMedCrossRefGoogle Scholar
  11. 11.
    Carr, S A, Hemmling, M E, Folena-Wasserman, G, Sweet, R W, Anumula, K, Barr, J R, Huddleston, M J, and Taylor, P (1989) Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry J.Biol Chem 264,21,286–21,295PubMedGoogle Scholar
  12. 12.
    Levy, J A. (1993) Pathogenesis of human immunodeficiency virus infection Microbiol Rev 57, 183–289PubMedGoogle Scholar
  13. 13.
    Lifson, J, Coutre, S., Huang, E, and Engleman, E (1986) Role of envelope glycoprotein carbohydrate in human immunodeficiency virus (HIV) infectivity and virus-induced cell fusion J.Exp.Med 164,2101–2106PubMedCrossRefGoogle Scholar
  14. 14.
    Hansen, J E S, Nielsen, C. M, Nielsen, C, Heegaard, P, Tathieson, L. R, and Nielsen, J 0 (1989) Correlation between carbohydrate structures on the envelope glycoprotein gp120 of HIV-1 and HIV-2 and syncytium inhibition with lectins AIDS 3, 635–641PubMedCrossRefGoogle Scholar
  15. 15.
    Fenouillet, E., Clerget-Raslain, B, Gluckman, J C, Guetard, D, Montagnier, L, and Bahraoui, E (1989) Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor J. Exp Med 169, 807–822PubMedCrossRefGoogle Scholar
  16. 16.
    Pineau, N., Aucouturier, P, Brugier, J. C, and Preud’homme, J L. (1990) Jacalin a lectin mitogenic for human CD4 T-lymphocytes Clin Exp immunol 80,420–425.PubMedCrossRefGoogle Scholar
  17. 17.
    Favero, J, Corbeau, P, Nicolas, M, Benkirane, M, Trave, G, Dixon, J F P, Aucouturier, P, Rasheed, S, Parker, J W, Liautard, J P, Devaux, C., and Dornand, J (1993) Inhibition of human immunodeficiency virus infection by the lectin jacalin and by a derived peptide showing a sequence similarity with gp120 Eur J Immunol 23, 179–185PubMedCrossRefGoogle Scholar
  18. 18.
    Taimi, M, Dornand, J, Nicolas, M., Marti, J, and Favero, J (1994) Involvement of CD4 in interleukin-6 secretion by U937 monocytic cells stimulated with the lectin jacalin J. Leuk Biol 5,214–220Google Scholar
  19. 19.
    Lafont, V, Dornand, J, Dupuy d’Angeac A, Momer, S, Alcover, A, and Favero, J (1994) Jacalin. a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex. J. Leuk Biol 56,521–524Google Scholar
  20. 20.
    Sastry, M. V. K, BanarJee, P, Patanjali, S R., Swamy, M. J, Swarnalatha, G V., and Surolia, A. (1986) Analysis of saccharide binding to Artocarpus integrifolia lectin reveals specific recognition of T-antigen (β-D-Gal(1→3)D-GalNac) J. Biol Chem 261, 11,726–11,733PubMedGoogle Scholar
  21. 21.
    Corbeau, P, Devaux, C, Kourilsky, F, and Chermann, J C (1990) An early postinfection signal mediated by monoclonal anti-β2 microglobulin antibody is responsible for delayed production of human immunodeficiency virus type 1 In peripheral blood mononuclear cells J. Virol 64,1459–1464PubMedGoogle Scholar
  22. 22.
    Hasunuma, T., Tsubota. H, Watanabe. M, Chen, Z W, Lord, C I, Burkly, L C Daley, J F, and Letvin, N L (1992) Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes J. Immunol 148, 1841–1846PubMedGoogle Scholar
  23. 23.
    Juszczak, R J, Turchin, H, Truneh, A, Culp, J, and Kassis, S (1991) Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p561ck with CD4 in human T-lymphocytes J. Biol Chem 266, 11,176–11,183PubMedGoogle Scholar
  24. 24.
    Cohen, D I, Tani, Y., Tian, H., Boone, E, Samelson, L E, and Lane, H C (1992) Participation of tyrosine phosphorylation in the cytopathic effect of human immunodeficlency virus-1 Science 256, 542–545PubMedCrossRefGoogle Scholar
  25. 25.
    Yoshida, H., Koga, Y, Moroi, Y., Kimura, G, and Nomoto, K. (1992) The effect of P561ck, a lymphocyte specific protein kinase, on syncytium formation induced by human immunodeficlency virus envelope glycoprotein Internal Immunol 4,233–242CrossRefGoogle Scholar
  26. 26.
    Soula, M, Fagard, R, and Fisher, S. (1992) Interaction of human immunodeficiency virus glycoprotein gp160 with CD4 in Jurkat cells increases p561ck autophosphorylation and kinase activity. Int Immunol 4, 295–299PubMedCrossRefGoogle Scholar
  27. 27.
    Tremblay, M, Meloche, S., Graton, S, Wainberg, M A, and Sekaly, R P (1994) Association of p561ck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J 13,774–783.PubMedGoogle Scholar
  28. 28.
    Carrel, S., Salvi, S, Gallay, P, Rapin, C, and Sekaly, R P (1991) Positive signal transduction via surface CD4 molecules does not need coexpression of the CD3/ TcR complex. Res Immunol 142,97–108PubMedCrossRefGoogle Scholar
  29. 29.
    Saggioro, D, Sorio C, Calderazzo, F, Callegaro, L, Panozzo, M., Berton, G., and Chieco-Bianchi, L (1993) Mechanism of action of the monosialoganglioside GM1 as a modulator of CD4 expression. J. Biol Chem 268, 1368–1375.PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Jean Favero
    • 1
  • Virginie Lafont
    • 1
  1. 1.Microbiologie et Pathologie Cellulaire Infectieuse, Institut National de la Sante et de la Recherche MedicaleUniversite de Montpellier IIMontpellierFrance

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