Abstract
Phage-displayed peptide libraries (1) constitute a powerful and effective source for the isolation of peptide mimics of antibody epitopes. Such peptides represent positrve images of the natural antigens and are, therefore, able to mimic some of their blological properties (2). We have developed a methodology to identify phage-borne peptides mimicking disease-specific epitopes that does not require either the availability of or information on the original antigen (which can even be unknown). This application of phage-displayed peptide libraries opens new routes for the identification and characterization of reagents useful for diagnosis, prognosis, and prevention of diseases.
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© 1998 Humana Press Inc., Totowa, NJ
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Folgori, A., Luzzago, A., Monaci, P., Nicosia, A., Cortese, R., Felici, F. (1998). Identification of Disease-Specific Epitopes. In: Cabilly, S. (eds) Combinatorial Peptide Library Protocols. Methods in Molecular Biology™, vol 87. Humana Press. https://doi.org/10.1385/0-89603-392-9:195
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DOI: https://doi.org/10.1385/0-89603-392-9:195
Publisher Name: Humana Press
Print ISBN: 978-0-89603-392-4
Online ISBN: 978-1-59259-571-6
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