Crystallization of Macromolecules for Three-Dimensional Structure Determination

  • Ben Luisi
  • Marie Anderson
  • Graham Hope
Part of the Methods in Molecular Medicine book series (MIMM, volume 10)


The last decade has seen a remarkable flourishing of the biological structure field. This blossoming has brought an explosion of stereochemical information, and has been made possible by the combined improvement in techniques of X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and the bulk preparation of biological materials. Most crucial, however, has been the desire of the experimental biologists to follow research problems to the level of stereochemistry, which is the ultimate reductionist limit of molecular biology. This aim has been driven by the anticipation that such knowledge may permit better understanding and even engineering of biological function.


Nuclear Magnetic Resonance Nuclear Magnetic Resonance Spectroscopy Protein Crystal Electron Microscope Grid Guanidinium Hydrochloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 1998

Authors and Affiliations

  • Ben Luisi
    • 1
    • 2
  • Marie Anderson
    • 1
  • Graham Hope
    • 1
  1. 1.MRC Virology UnitInstitute of VirologyGlasgowScotland, UK
  2. 2.Department of BiochemistryUniversity of CambridgeUK

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