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Noninvasive Prenatal Diagnosis Using Fetal Cells in Maternal Blood

  • Protocol
Molecular Diagnosis of Genetic Diseases

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 5))

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Abstract

It has been a long-sought goal of human genetics to develop safe and reliable prenatal diagnostic procedures that constitute no risk to the fetus. At present, the safety of available methods is limited by the need to obtam fetal tissues through invasive means, such as chorlomc villus sampling (CVS) and amniocentesis, which constitute a risk to the fetus. One potential noninvasive approach for prenatal diagnosis is to use fetal cells that have entered into maternal circulation during pregnancy as a source of fetal material for analysis.

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Author information

Authors and Affiliations

  1. Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK

    Y. M. Dennis Lo

Authors
  1. Y. M. Dennis Lo
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Editor information

Editors and Affiliations

  1. Regional Molecular Genetics Laboratory, St. Mary’s Hospital, Manchester, UK

    Rob Elles

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© 1996 Humana Press Inc., Totowa, NJ

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Lo, Y.M.D. (1996). Noninvasive Prenatal Diagnosis Using Fetal Cells in Maternal Blood. In: Elles, R. (eds) Molecular Diagnosis of Genetic Diseases. Methods in Molecular Medicine™, vol 5. Humana Press. https://doi.org/10.1385/0-89603-346-5:237

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  • DOI: https://doi.org/10.1385/0-89603-346-5:237

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-346-7

  • Online ISBN: 978-1-59259-589-1

  • eBook Packages: Springer Protocols

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