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New Instrumental Approaches to Collision-Induced Dissociation Using a Time-of-Flight Instrument

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Protein and Peptide Analysis by Mass Spectrometry

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 61))

Abstract

Described here is one of the most powerful methods of mass spectrometry (MS) for molecular structure analysis, introduced under the acronym “PSD-MALDI” (postsource decay with matrix-assisted laser desorption/ionization) MS (16). It has found rapid and wide acceptance (711), mainly because of its attractive features, such as high sensitivity, high tolerance of various sample conditions, speed of analysis, and limited instrumental requirements. All major mass spectrometer companies have now extended their product line to support the PSD-MALDI mode for bioorganic structure analysis.

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References

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© 1996 Humana Press Inc., Totowa, NJ

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Spengler, B. (1996). New Instrumental Approaches to Collision-Induced Dissociation Using a Time-of-Flight Instrument. In: Chapman, J.R. (eds) Protein and Peptide Analysis by Mass Spectrometry. Methods in Molecular Biology™, vol 61. Humana Press. https://doi.org/10.1385/0-89603-345-7:43

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  • DOI: https://doi.org/10.1385/0-89603-345-7:43

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-345-0

  • Online ISBN: 978-1-59259-547-1

  • eBook Packages: Springer Protocols

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