Abstract
A significant proportion of genetic disorders are caused by point mutations in proteins. Structural studies of these mutated proteins are now mostly carried out by genetic methods. Even so, mass spectrometry (MS) is a rapid and excellent method of mutation analysis, especially when sufficient amounts of the gene product are obtained. It is also useful for verifying the structure of recombinant proteins.
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References
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© 1996 Humana Press Inc., Totowa, NJ
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Wada, Y. (1996). Structural Analysis of Protein Variants. In: Chapman, J.R. (eds) Protein and Peptide Analysis by Mass Spectrometry. Methods in Molecular Biology™, vol 61. Humana Press. https://doi.org/10.1385/0-89603-345-7:101
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DOI: https://doi.org/10.1385/0-89603-345-7:101
Publisher Name: Humana Press
Print ISBN: 978-0-89603-345-0
Online ISBN: 978-1-59259-547-1
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