Cystic Fibrosis Airway Epithelial Cell Culture

  • Manuel A. Lega
Part of the Methods in Molecular Medicine book series (MIMM, volume 2)


Cystic fibrosis (CF) is the most frequent (incidence around l/2500 live births) genetic cause of death among Caucasians. It is an autosomal recessive disorder compromising the secretory epithelia. Clinically, CF is a polymorphic disease showing abnormal functioning of the airways, the digestive apparatus (pancreas and intestine), the reproductive tract, and the sweat glands, leading to respiratory insufficiency, mainutrition, male sterility, and production of salty sweat. The average life-span of CF patients falls around 25–30 yr of age in the United States and Europe, and around 10 yr of age in Latin America (1, 2). Respiratory infections are the cause of death of more than 90% of CF patients. No curative treatments are as yet available for CF.


Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Cystic Fibrosis Patient Airway Epithelial Cell Submucosal Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 1996

Authors and Affiliations

  • Manuel A. Lega
    • 1
  1. 1.Department of Biology, Human Gene Therapy Working GroupUniversidad Nacional del SurBahia BlancaArgentina

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