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Voltammetric Methods in Brain Systems pp 221–268Cite as

The Measurement of Brain Ascorbate In Vivo and Its Link with Excitatory Amino Acid Neurotransmission

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Part of the book series: Neuromethods ((NM,volume 27))

Abstract

L-Ascorbic acid (AA, vitamin C) is found throughout the plant and animal kingdoms (Davies et al., 1991). A major function of AA is as an antioxidant, protecting tissues from harmful free radicals and maintaining certain enzymes in their reduced form (Padh, 1990). Although mechanisms of its roles are often unknown or only poorly understood, details of specific interactions of AA with a variety of molecular complexes, such as calcium channels (Parsey and Matteson, 1993) and neurotransmitter receptors (Majewska et al., 1990), have recently been revealed.

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  1. Chemistry Department, UniversityCollege, Dublin, Ireland

    Robert D. O’Neill

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  1. Robert D. O’Neill
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  1. Uniuersity of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  2. Unioersity of Alberta, Edmonton, Canada

    Glen B. Baker

  3. University of Kansas, Lawrence, KS

    Ralph N. Adams

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O’Neill, R.D. (1995). The Measurement of Brain Ascorbate In Vivo and Its Link with Excitatory Amino Acid Neurotransmission. In: Boulton, A.A., Baker, G.B., Adams, R.N. (eds) Voltammetric Methods in Brain Systems. Neuromethods, vol 27. Humana Press. https://doi.org/10.1385/0-89603-312-0:221

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