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Regional Differences in Dopamine Release, Uptake, and Diffusion Measured by Fast-Scan Cyclic Voltammetry

  • Protocol
Voltammetric Methods in Brain Systems

Part of the book series: Neuromethods ((NM,volume 27))

Abstract

The neurotransmitter dopamine (DA) is present in high concentrations in select areas of the central nervous system (CNS), including the striatal and limbic regions. Appropriate control of its role in communication between neurons is clearly important for normal function. Possibly the most recognizable aspect of improper regulation of DA is Parkinson’s disease. The symptoms of this neurodegenerative disorder, which affects the control of motor activity and results from deterioration of nigrostriatal DA neurons, are treated by various means that attempt to restore dopaminergic capacity. Dopamine is also thought to subserve cognitive, emotive, and even endocrine functions, and has been implicated in other neuropathologies, such as schizophrenia and substance addiction.

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  1. Department of Chemistry, The University of North Carolina, Chapel Hill, NC

    Paul A. Garris & R. Mark Wightman

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  1. Uniuersity of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  2. Unioersity of Alberta, Edmonton, Canada

    Glen B. Baker

  3. University of Kansas, Lawrence, KS

    Ralph N. Adams

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Garris, P.A., Mark Wightman, R. (1995). Regional Differences in Dopamine Release, Uptake, and Diffusion Measured by Fast-Scan Cyclic Voltammetry. In: Boulton, A.A., Baker, G.B., Adams, R.N. (eds) Voltammetric Methods in Brain Systems. Neuromethods, vol 27. Humana Press. https://doi.org/10.1385/0-89603-312-0:179

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  • DOI: https://doi.org/10.1385/0-89603-312-0:179

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-312-2

  • Online ISBN: 978-1-59259-632-4

  • eBook Packages: Springer Protocols

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