Antisense Blockade of Expression

SNAP-25 In Vitro and In Vivo
  • Marina Catsicas
  • Astrid Osen-Sand
  • Julie K. Staple
  • Kenneth A. Jones
  • Guidon Ayala
  • Jonathan Knowles
  • Gabriele Grenningloh
  • Emilio Merlo Pith
  • Stefan Catsicas
Part of the Methods in Molecular Medicine book series (MIMM, volume 1)

Abstract

With the advent of modern molecular genetics and molecular biology, we will face more and more situations where novel gene products with unknown functions are identified. Genetic linkage analysis will allow the association of novel or known genes to Important diseases (1). Similarly, sensitlve differential cloning procedures will identify rare genes expressed in specific physiological or pathological situations (1, 3). In both cases, establishing the precise function of the identified gene is an essential step for the understanding of the cellular mechanisms that either lead to the disease or are pivotal in important physiological processes.

Keywords

Sugar Toxicity Sucrose Cysteine Retina 

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Copyright information

© Humana Press Inc., Totowa, NJ 1996

Authors and Affiliations

  • Marina Catsicas
    • 1
  • Astrid Osen-Sand
    • 1
  • Julie K. Staple
    • 1
  • Kenneth A. Jones
    • 1
  • Guidon Ayala
    • 1
  • Jonathan Knowles
    • 1
  • Gabriele Grenningloh
    • 1
  • Emilio Merlo Pith
    • 1
  • Stefan Catsicas
    • 1
  1. 1.Glaxo Institute for Molecular BiologyGenevaSwitzerland

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