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The Drosophila melanogaster Assay

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In Vitro Toxicity Testing Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 43))

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Abstract

The method described is based on that developed by Schuler and colleagues (1,2 and recently refined (3).

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References

  1. Schuler, R. L, Hardin, B. D, and Niemeier, R. W. (1982) Drosophila as a tool for the rapid assessment of chemicals for teratogenicity Terat. Carc. Mutat. 2, 293–301

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  2. Schuler, R. L., Radike, M. A., Hardin, B. D., and Niemeier, R. W. (1985) Pattern of response of intact Drosophila to known teratogens. J Am. Coll Toxicol 4(4), 291–303.

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  3. Lynch, D. W., Schuler, R. L, Hood, R. D., and Davis, D G. (1991) Evaluation of Drosophila for screening developmental toxicants: test results with eighteen chemicals and presentation of a new Drosophila bioassay. Terat. Carc. Mutat. 11, 147–173

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  4. Sachs, L. (1984) Applied Statistics: A Handbook of Techniques, 2nd ed., Springer-Verlag, New York.

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  5. Ranganathan, S., Davis, D. G., and Hood, R, D. (1987). Developmental toxicity of ethanol in Drosophila melanogaster. Teratology 36, 45–49.

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  6. Goldstein, S. H. and Babich, H. (1989) Differential effects of arsenite and arsenate to Drosophila melanogaster in a combined adult/developmental toxicity assay. Bull. Environ. Contam. Toxicol. 42, 276–282.

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  7. Bournias-Vardiabasis, N., Teplitz, R. L., Chernoff, G. F, and Seecof, R. L. (1983) Detection of teratogens in the Drosophila embryonic cell culture test: assay of 100 chemicals. Teratology 28, 109–122

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  8. Bournias-Vardiabasis, N. and Flores, J. (1983) Drug metabolising enzymes in Drosophila melanogaster teratogenicity of cyclophosphamide in vitro. Terat. Carc. Mutat. 3, 255–262

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Author information

Authors and Affiliations

  1. Zeneca Pharmaceuticals, MacclesfieId Cheshire, UK

    Wendy J. Davies

  2. Research and Technical Operations, SmithKline Beecham, Weybridge, UK

    Stuart J. Freeman

Authors
  1. Wendy J. Davies
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  2. Stuart J. Freeman
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Editor information

Editors and Affiliations

  1. University of Hertfordshire, Hatfield, UK

    Sheila O’Hare  & Chris K. Atterwill  & 

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© 1995 Humana Press Inc , Totowa, NJ

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Davies, W.J., Freeman, S.J. (1995). The Drosophila melanogaster Assay. In: O’Hare, S., Atterwill, C.K. (eds) In Vitro Toxicity Testing Protocols. Methods in Molecular Biology™, vol 43. Humana Press. https://doi.org/10.1385/0-89603-282-5:317

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  • DOI: https://doi.org/10.1385/0-89603-282-5:317

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-282-8

  • Online ISBN: 978-1-59259-530-3

  • eBook Packages: Springer Protocols

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