Abstract
In this test, rabbit-derived cornea1 cells are cultured in the presence of test compounds, the toxicity of which are determined by their effects on cell viability. A decrease in cell number, as measured by uptake of the dye Neutral Red, serves as an indicator of potential cytotoxicity. This test has been proposed as a potential replacement alternative for the Draize Eye Irritation test (1).
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References
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© 1995 Humana Press Inc , Totowa, NJ
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Blein-Sella, O., Adolphe, M. (1995). SIRC Cytotoxicity Test. In: O’Hare, S., Atterwill, C.K. (eds) In Vitro Toxicity Testing Protocols. Methods in Molecular Biology™, vol 43. Humana Press. https://doi.org/10.1385/0-89603-282-5:161
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DOI: https://doi.org/10.1385/0-89603-282-5:161
Publisher Name: Humana Press
Print ISBN: 978-0-89603-282-8
Online ISBN: 978-1-59259-530-3
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