Chick Embryotoxicity Screening Test (CHEST I and II)

  • Wendy J. Davies
  • Stuart J. Freeman
Part of the Methods in Molecular Biology™ book series (MIMB, volume 43)


The chick embryo has been used for the study of experimental teratogenicity by various techniques (1, 2, 3, 4). This chapter describes a method developed by Jelinek (5,6) that combines a standardized technique (CHEST I) with other techniques (CHEST II); it allows the administration of small amounts of test compound and the measurement of a quantitative endpoint (CHEST I).


Test Compound Chick Embryo Ocular Micrometer Shell Membrane Trunk Length 
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Copyright information

© Humana Press Inc , Totowa, NJ 1995

Authors and Affiliations

  • Wendy J. Davies
    • 1
  • Stuart J. Freeman
    • 2
  1. 1.Zeneca PharmaceuticalsMacclesfieId CheshireUK
  2. 2.Research and Technical Operations, SmithKline BeechamWeybridgeUK

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