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HF Cleavage and Deprotection Procedures for Peptides Synthesized Using a Boc/Bzl Strategy

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Peptide Synthesis Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 35))

Abstract

On completion of chemical synthesis of the peptide chain, the final step requires the removal from the solid-phase support and liberation of the protected side chains of the trifunctional amino acids (1). Many different approaches to this problem have been established, but the procedure most widely used for all Boc/Bzl-based peptides has been treatment with liquid HF.

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Author information

Authors and Affiliations

  1. Bachem Bioscience, King of Prussia, PA, USA

    Michael W. Pennington

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  1. Michael W. Pennington
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Editors and Affiliations

  1. Bachem Bioscience, King of Prussia, PA, USA

    Michael W. Pennington

  2. University of Florida, Gainesville, FL, USA

    Ben M. Dunn

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© 1994 Humana Press Inc.

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Pennington, M.W. (1994). HF Cleavage and Deprotection Procedures for Peptides Synthesized Using a Boc/Bzl Strategy. In: Pennington, M.W., Dunn, B.M. (eds) Peptide Synthesis Protocols. Methods in Molecular Biology, vol 35. Humana Press, Totowa, NJ. https://doi.org/10.1385/0-89603-273-6:41

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  • DOI: https://doi.org/10.1385/0-89603-273-6:41

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-273-6

  • Online ISBN: 978-1-59259-522-8

  • eBook Packages: Springer Protocols

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