Bromoacetylated Synthetic Peptides
Modern peptide synthesis techniques make it straightforward to synthesize linear peptides that are based on amino acid sequences of parent proteins. It is well known that the linear peptide itself often will not share the same activity as the peptide in its original biological environment provided by the native protein. In addition, the scientific reasons for making a peptide will often not be simply to mimic an activity of a protein—whatever it may be—with a small synthetic substitute, but the goal may be to enhance or decrease an activity found in a native protein. Therefore, it is important to be able to modify the conformations and configurations of a linear peptide by cyclizing, polymerizing, or conjugating the peptide.
KeywordsCyclic Peptide Hydrogen Fluoride Free Thiol Linear Peptide Peptide Conjugate
- 8.Inman, J. K., Highet, P. F., Kolodny, N., and Robey, F. A. (1991) Synthesis of Nα- (tert-butoxycarbonyl)-Nɛ-[N-(bromoacetyl)-β-alanyl]-L-lysine· its use in peptide synthesis for placing a bromoacetyl cross-linking function at any desired sequence position. Bioconjugate Chem. 2(6), 458–463.CrossRefGoogle Scholar
- 11.Robey, F A., Harris, T. A., Heegaard, N. H. H., Nguyen, A. K., and Batinic, D (1992) Syntheses, analyses and uses of site-specific bromoacetyl-denvatized synthetic peptides: starting materials for countless new cyclic peptides, peptomers and peptide conjugates. Chemica Oggi Jan/Feb., 27–31.Google Scholar
- 13.White, F. H. (1972) Thiolation, in Methods in Enzymology, vol. 25 (Hirs, C. H. W. and Timasheff, S. N, eds.), Academic, New York, pp. 541–546Google Scholar