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Transgenic Animals and the Study of Cancer

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Transgenesis Techniques

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 18))

Abstract

This chapter seeks to outline the strategies being employed to exploit transgenic mice as a tool in the study of cancer. Rather than catalog the many different oncogene and oncogene-promoter combinations that have been introduced into transgenic mice to elicit tumors, I will concentrate on a single system that epitomizes the general approach. That system, pioneered by Philip Leder of Harvard University, is mammary carcinogenesis induced by oncogene expression directed by the Mouse Mammary Tumor Virus (MMTV) enhancer-promoter.

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Authors and Affiliations

  1. Neuropeptide Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, Republic of Singapore

    David Murphy

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  1. David Murphy
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  1. National University of Singapore, Republic of Singapore

    David Murphy  & David A. Carter  & 

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© 1993 Humana Press Inc., Totowa, NJ

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Murphy, D. (1993). Transgenic Animals and the Study of Cancer. In: Murphy, D., Carter, D.A. (eds) Transgenesis Techniques. Methods in Molecular Biology™, vol 18. Humana Press. https://doi.org/10.1385/0-89603-245-0:23

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  • DOI: https://doi.org/10.1385/0-89603-245-0:23

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-245-3

  • Online ISBN: 978-1-59259-505-1

  • eBook Packages: Springer Protocols

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