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Genetic Animal Models

A User’s Guide

  • Protocol
Animal Models of Drug Addiction

Part of the book series: Neuromethods ((NM,volume 24))

Abstract

The use of genetically specified animals to address fundamental questions in neuroscience continues to grow apace. In the early 1950s, (Mardones 1951) reported the development by selective breeding of strains of rats preferring and not preferring to drink alcohol. (McClearn and Rodgers 1959) reported that inbred mouse strains differed in their preference for 10% ethanol-in-tap water solutions. These pioneering studies represent the two methods still most frequently used today, selective breeding and the analysis of preexisting, defined genotypes (see below).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Colorado School of Medicine, Denver, CO

    R. Adron Harris

  2. Departments of Medical Psychology and Pharmacology, Oregon Health Sctences University, Portland, OR

    John C. Crabbe

Authors
  1. R. Adron Harris
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  2. John C. Crabbe
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Editor information

Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  2. University of Alberta, Edmonton, Canada

    Glen B. Baker

  3. University of Toronto, Toronto, Canada

    Peter H. Wu

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© 1992 The Humana Press Inc.

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Harris, R.A., Crabbe, J.C. (1992). Genetic Animal Models. In: Boulton, A.A., Baker, G.B., Wu, P.H. (eds) Animal Models of Drug Addiction. Neuromethods, vol 24. Humana Press. https://doi.org/10.1385/0-89603-217-5:65

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  • DOI: https://doi.org/10.1385/0-89603-217-5:65

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-217-0

  • Online ISBN: 978-1-59259-629-4

  • eBook Packages: Springer Protocols

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