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Models of Alcohol Consumption Using the Laboratory Rat

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Book cover Animal Models of Drug Addiction

Part of the book series: Neuromethods ((NM,volume 24))

Abstract

For 50 years, since the original work by (1940), rats have been used in experiments to model human alcohol abuse. The use of a nonhuman species, such as the rat, to model a behavior that seems to be inherently human has been justified in terms of the relatively economical and convenient provision of large, genetically uniform subject populations, and the degree of control that is possible over such factors as housing, diet, and previous drug experience. In addition, certain physiological or pharmacological manipulations can be administered to rats that would not be possible with human subjects.

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References

  • Aalto J. and Kiianmaa K. (1984) Circadian rhythms of water and alcohol intake: Effect of REM-sleep deprivation and lesion of the suprachiasmatic nucleus. Alcohol 1, 403–407.

    Article  PubMed  CAS  Google Scholar 

  • Beardsley P. M., Lemaire G. A., and Meisch R. A. (1978) Ethanol-reinforced behavior of rats with concurrent access to food and water. Psychopharmacology 59, 7–11.

    Article  PubMed  CAS  Google Scholar 

  • Beardsley P. M., Lemaire G. A., and Meisch R. A. (1983) Effects of minimum-interreinforcer interval on ethanol-maintained performance of rats. Pharmacol. Biochem. Behav. 19, 843–847.

    Article  PubMed  CAS  Google Scholar 

  • Burish T. G., Maisto S. A., Cooper A. M., and Sobell M. B. (1981) Effects of voluntary short-term abstinence from alcohol on subsequent drinking patterns of college students. J. Stud. Alcohol 42, 1013–1020.

    PubMed  CAS  Google Scholar 

  • Cappell H. and LeBlanc A. E. (1981) Tolerance and physical dependence: Do they play a role in alcohol and drug self-administration? in Research Advances in Alcohol and Drug Problems, vol. 6. Isreal Y., Glaser F. B., Kalant H., Popham R. E., Schmidt W., and Smart R. G., eds., Plenum, New York, pp. 159–196.

    Google Scholar 

  • Carroll M. E., France C. P., and Meisch R.A. (1981) Intravenous self-administration of etonitazene, cocaine, and phencyclidine in rats during food deprivation and satiation. J. Pharmacol. Exp. Ther. 217, 241–247.

    PubMed  CAS  Google Scholar 

  • Carroll M. E. and Meisch R. A. (1984) Increased drug-reinforced behavior due to food deprivation, in Advances in Behavioral Pharmacology, vol. 4. Thompson T., Dews P. B., and Barrett J. E., eds., Academic, New York, pp, 47–88.

    Google Scholar 

  • Cicero T. J. (1979) A critique of animal analogues of alcoholism, in Biochemistry and Pharmacology of Ethanol, vol. 2, Majchrowicz E. and Noble E. P., eds., Plenum, New York, pp. 533–560.

    Google Scholar 

  • Cloninger C. R. (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236, 410–416.

    Article  PubMed  CAS  Google Scholar 

  • Collins R. J., Weeks J. R., Cooper M. M., Good P. I., and Russel R. R. (1984) Prediction of abuse liability of drugs using IV self-administration by rats. Psychopharmacology 82, 6–13.

    Article  PubMed  CAS  Google Scholar 

  • Cullen J. W., Croes R. A., and Gillis R. D. (1973) Alcohol selection by rats after experience with a sapid alcohol-sucrose solution. Q J. Stud. Alcohol 34, 769–773.

    PubMed  CAS  Google Scholar 

  • Dahl L. K., Heine M., and Tassinari L. (1962) Effects of chronic salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension. J. Exp. Med. 115, 1173–1190.

    Article  PubMed  CAS  Google Scholar 

  • Deitrich R. A. and Melchior C. L. (1985) A critical assessment of animal models for testing new drugs for altering ethanol intake, in Research Advances in New Psychopharmacological Treatments for Alcoholism, Naranjo C. A. and Sellers E. M., eds.), Excerpta Medica, Amsterdam, pp. 23–43.

    Google Scholar 

  • Deneau G., Yanagita T., and Seever M. H. (1969) Self-administration of psychoactive substances by the monkey. Psychopharmacologia (Berl.) 16, 30–84.

    Article  CAS  Google Scholar 

  • DeNoble V. J., Mele P. C., and Poter J. H. (1985) Intravenous self-administration of pentobarbital and ethanol in rats. Pharmacol. Biochem. Behav. 23, 759–763.

    Article  PubMed  CAS  Google Scholar 

  • Deutsch J. A. and Hardy W. T. (1976) Ethanol tolerance in the rat measured by the untasted intake of alcohol. Behav. Biol. 17, 379–389.

    Article  PubMed  CAS  Google Scholar 

  • Eriksson K. (1968) Genetic selection for voluntary alcohol consumption in the albino rat. Science 159, 739–741.

    Article  PubMed  CAS  Google Scholar 

  • Eriksson K. (1969) Factors affecting voluntary alcohol consumption in the albino rat. Ann. Zool. Fennici. 6, 227–265

    Google Scholar 

  • Falk J. L. (1961) Production of polydipsia in normal rats by an intermittent food schedule. Science 133, 195,196.

    Article  Google Scholar 

  • Falk J. L. (1971) The nature and determinants of adjunctive behavior. Physiol. Behav. 6, 577–588

    Article  PubMed  CAS  Google Scholar 

  • Falk J. L. (1983) Drug dependence: Myth or motive? Pharmacol. Biochem. Behav. 19, 385–391.

    Article  PubMed  CAS  Google Scholar 

  • Falk J. L. and Samson H. H. (1976) Schedule-induced physical dependence on ethanol. Pharmacol. Rev. 27, 449–464.

    Google Scholar 

  • Falk J. L., Samson H. H., and Winger G. (1972) Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat. Science 177, 811–813.

    Article  PubMed  CAS  Google Scholar 

  • Falk J. L. and Tang M. (1977) Animal model of alcoholism: Critique and progress in Alcohol Intoxication and Withdrawal, vol. 3B, Gross M. M., ed. Plenum, New York, pp. 465–493.

    Google Scholar 

  • Freed E. X., Carpenter J. A., and Hymowitz N. (1970) Acquisition and extinction of schedule-induced polydipsic consumption of alcohol and water. Psychol. Rep. 26, 915–922.

    PubMed  CAS  Google Scholar 

  • Freed E. X. and Lester D. (1970) Schedule-induced consumption of ethanol: Calories or chemotherapy? Physiol. Behav. 5, 555–560.

    Article  PubMed  CAS  Google Scholar 

  • Froehlich J. C., Harts J., Lumeng L., and Li T.-K. (1988) Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference. Pharmacol. Biochem. Behav. 32, 215–222.

    Article  Google Scholar 

  • Gatto G. J., Murphy J. M., Waller M. B., McBride W. J., Lumeng L., and Li T.-K. (1987a) Chronic ethanol tolerance through free-choice drinking in the P line of alcohol preferring rats. Pharmacol. Biochem. Behav. 28, 111–115.

    Article  PubMed  CAS  Google Scholar 

  • Gatto G. J., Murphy J. M., Waller M. B., McBride W. J., Lumeng L., and Li T.-K. (1987b) Persistence of tolerance to a single dose of ethanol in the selectively bred alcohol-preferring P rats. Pharmacol. Biochem. Behav. 28, 105–110.

    Article  PubMed  CAS  Google Scholar 

  • Gill K., France S., and Amit Z. (1986) Voluntary ethanol consumption in rats: An examination of blood-brain levels and behavior. Alcoholism: Clin. Exp. Res. 10, 457–462.

    Article  CAS  Google Scholar 

  • Gottheil E., Murphy G. F., Skoloda T. E., and Corbit L. O. (1972) Fixed interval drinking decision: II. Drinking and discomfort in 25 alcoholics. Q. J. Stud. Alcohol 33, 325–340.

    PubMed  CAS  Google Scholar 

  • Grupp L. A. (1981) An investigation of intravenous ethanol self-administration in rats using a fixed ratio schedule of reinforcement. Physiol. Psychol. 9, 359–363.

    CAS  Google Scholar 

  • Grupp L. A., Kalant H., and Leenen F. H. H. (1989) Alcohol intake is inversely related to plasma renin activity in the genetically selected alcohol-preferring and-non-preferring lines of rats. Pharmacol. Biochem. Behav. 32, 1061–1063.

    Article  PubMed  CAS  Google Scholar 

  • Grupp L. A., Perlanski E., Wanless I. R., and Stewart R. B. (1986a) Voluntary alcohol intake in the hypertension prone Dahl rat. Pharmacol. Biochem. Behav. 24, 1167–1174.

    Article  PubMed  CAS  Google Scholar 

  • Grupp L. A., Perlanski E., and Stewart R. B. (1986b) Diet and diuretics in the reduction of voluntary alcohol drinking in rats. Alcohol and Alcoholism 21, 75–79.

    PubMed  CAS  Google Scholar 

  • Henningfield J. E. and Meisch R. A. (1975) Ethanol-reinforced responding and intake as a function of volume per reinforcement. Pharmacol. Biochem. Behav. 3, 437–441.

    Article  PubMed  CAS  Google Scholar 

  • Iwai J., Dahl L. K., and Knudsen K. D. (1973), Genetic influences on the renin-angiotensin system. Low renin activities in hypertension-prone rats. Circ. Res. 32, 678–684.

    PubMed  CAS  Google Scholar 

  • Kakihana R., Brown D. R., McCleam G. E., and Tabershaw I. R. (1966) Brain sensitivity to alcohol in inbred mouse strains. Science 154, 1574,1575.

    Article  Google Scholar 

  • Kalant H. (1983) Animal models of alcohol and drug dependence: Some questions, answers, and clinical implications, in Etiologic Aspects of Alcohol and Drug Abuse Gottheil E., Druley K. A., Skododa T. E., and Waxman H. M., eds., C. C. Thomas, Springfield, IL, pp. 14–29.

    Google Scholar 

  • Kulkosky P. J. (1979) Effect of addition of ethanol and NaCl on saccharin + glucose polydipsia. Pharmacol. Biochem. Behav. 10, 277–283.

    Article  PubMed  CAS  Google Scholar 

  • Lester D. (1961) Self-maintenance of intoxication in the rat. Q, J. Stud. Alcohol 22, 223–231.

    CAS  Google Scholar 

  • Lester D. and Freed E. (1972) The rat views alcohol—Nutrition or nirvana? in Biological Aspects of Alcohol Consumption, Forsander O. and Eriksson K., eds., The Finnish Foundation for Alcohol Studies, Helsinki, pp. 27–29.

    Google Scholar 

  • Lester D. and Freed E. (1973) Criteria for an animal model of alcoholism. Pharmacol. Biochem. Behav. 1, 103–107.

    Article  PubMed  CAS  Google Scholar 

  • Li T.-K., Lumeng L., McBride W. J., and Waller M. B. (1979) Progress toward a voluntary oral consumption model of alcoholism. Drug Alcohol Depend. 4, 45–60.

    Article  PubMed  CAS  Google Scholar 

  • Linseman M. A. (1987) Alcohol consumption in free-feeding rats: Procedural, genetic and pharmacokinetic factors. Psychopharmacology 92, 254–261.

    Article  PubMed  CAS  Google Scholar 

  • Linseman M. A. (1988) Consumption of alcohol compared to another bitter solution in a limited access drinking paradigm. Alcohol 5, 301–303.

    Article  PubMed  CAS  Google Scholar 

  • MacDonnell J. S. and Marcucella H. (1979) Increasing the rate of ethanol consumption in food-and water-satiated rats. Pharmacol. Biochem. Behav. 10, 211–216.

    Article  Google Scholar 

  • Mardones J. and Segozia-Riquelene N. (1983) Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains. Neurobehav. Toxicol. Teratol. 5, 171–178.

    PubMed  CAS  Google Scholar 

  • Meisch R. A. (1976) The function of schedule-induced-polydipsia in establishing ethanol as a positive reinforcer. Pharmacol. Rev. 27, 465–473.

    Google Scholar 

  • Meisch R. A. (1984) Alcohol self-administration by experimental animals, in Research Advances in Alcohol and Drug Problems, vol. 8, Smart R. G., Glaser F. B., Isreal Y., Cappell H., Kalant H., Schmidt W., and Sellers E. M., eds., Plenum, New York, pp. 23–45.

    Google Scholar 

  • Meisch R. A. and Beardsley P. (1975) Ethanol as a reinforcer for rats: Effects of concurrent access to water and alternate positions of water and ethanol. Psychopharmacologia (Berl.) 43, 19–23.

    Article  CAS  Google Scholar 

  • Meisch R. A. and Thompson T. (1971) Ethanol intake in the absence of concurrent food reinforcement. Psychopharmacologia (Berl.) 22, 72–79.

    Article  CAS  Google Scholar 

  • Meisch R. A. and Thompson T. (1974a) Rapid establishment of ethanol as a reinforcer for rats. Psychopharmacologia (Berl.) 37, 311–321.

    Article  CAS  Google Scholar 

  • Meisch R. A. and Thompson T. (1974b) Ethanol intake as a function of concentration during food deprivation and satiation. Pharmacol. Biochem. Behav. 2, 589–596.

    Article  PubMed  CAS  Google Scholar 

  • Mello N. K. (1973) A review of methods to induce alcohol addiction in animals. Pharmacol. Biochem. Behav. 1, 89–101.

    Article  PubMed  CAS  Google Scholar 

  • Murphy J. M., Gatto G. J., Waller M. B., McBride W. J., Lumeng L., and Li T.-K. (1986) Effects of scheduled access on ethanol intake by the alcohol preferring P line of rats. Alcohol 3, 331–336.

    Article  PubMed  CAS  Google Scholar 

  • Numan R. (1981) Multiple exposures to ethanol facilitate intravenous self-administration by rats. Pharmacol. Biochem. Behav. 15, 101–108.

    Article  PubMed  CAS  Google Scholar 

  • Numan R., Naparzewska A. M., and Adler C. M. (1984) Absence of reinforcement with low dose intravenous ethanol self-administration in rats. Phamacol. Biochem. Behav. 21, 609–615.

    Article  CAS  Google Scholar 

  • Oei T. P. S. and Singer G. (1979) Effects of a fixed time schedule and body weight on ethanol self-administration. Pharmacol. Biochem. Behav. 10, 767–770.

    Article  PubMed  CAS  Google Scholar 

  • Pfeffer A. O. and Samson H. H. (1985) Oral ethanol reinforcement in the rat: Effects of acute amphetamine. Alcohol 2, 693–697.

    Article  PubMed  CAS  Google Scholar 

  • Pinel J. P. J and Huang E. (1976) Effects of periodic withdrawal on ethanol and saccharin selection in rats. Physiol. Behav. 16, 693–698.

    Article  PubMed  CAS  Google Scholar 

  • Richter C. P. (1941) Alcohol as food. Q. J. Stud. Alcohol 1, 650–662.

    CAS  Google Scholar 

  • Richter C. P. and Campbell K. H. (1940) Alcohol taste thresholds and concentrations of solutions preferred by rats. Science 9, 507,508.

    Google Scholar 

  • Ritz M. C., George F. R., deFiebre C. M., and Meisch R. A. (1986) Genetic differences in the establishment of ethanol as a reinforcer. Pharmacol. Biochem. Behav. 24, 1089–1094.

    Article  PubMed  CAS  Google Scholar 

  • Samson H. H. (1986) Initiation of ethanol reinforcement using a sucrose substitution procedure in food-and water-sated rats. Alcoholism: Clin. Exp. Res. 10, 436–442.

    Article  CAS  Google Scholar 

  • Samson H. H. and Doyle T. F. (1985) Oral ethanol self-administration in the rat: Effect of naloxone. Pharmacol. Biochem. Behav. 22, 91–99.

    Article  PubMed  CAS  Google Scholar 

  • Samson H. H. and Falk J. L. (1974) Alternation of fluid preference in ethanol-dependent animals. J. Pharmacol. Behav. Ther. 190, 365–376.

    CAS  Google Scholar 

  • Samson H. H. and Falk J. L. (1975) Pattern of daily blood ethanol elevation and the development of physical dependence. Pharmacol. Biochem. Behav. 3, 1119–1123.

    Article  PubMed  CAS  Google Scholar 

  • Samson H. H. and Grant K. A. (1985) Chlordiazepoxide effects on ethanol self-administration: Dependence on concurrent conditions. J. Exp. Anal. Behav. 43, 353–364.

    Article  PubMed  CAS  Google Scholar 

  • Samson H. H. and Pfeffer A. O. (1987) Initiation of ethanol-maintained responding using a schedule-induction procedure in free feeding rats. Alcohol Drug Res. 7, 461–469.

    PubMed  CAS  Google Scholar 

  • Samson H. H., Pfeffer A. O., and Tolliver G. A. (1988) Oral ethanol self-administration in rats: Models of alcohol-seeking behavior. Alcoholism: Clin. Exp. Res. 12, 591–598.

    Article  CAS  Google Scholar 

  • Samson H. H., Tolliver G. A., Lumeng L., and Li T.-K. (1989) Ethanol reinforcement in the alcohol-nonpreferring (NP) rat: Initiation using behavioral techniques without food restriction. Alcoholism: Clin. Exp. Res. 13, 378–385.

    Article  CAS  Google Scholar 

  • Sinclair J. D. and Senter R. J. (1967) Increased preference for ethanol in rats following alcohol deprivation. Psychon. Sci. 8, 11,12.

    Google Scholar 

  • Sinclair J. D. and Senter R. J. (1968) Development of an alcohol deprivation effect in rats. Q. J. Stud. Alc. 29, 863–867.

    CAS  Google Scholar 

  • Sinden J. D. and LeMagnen J. (1982) Parameters of low-dose ethanol intravenous self-administration in the rat. Pharmacol. Biochem. Behav. 16, 181–183.

    Article  PubMed  CAS  Google Scholar 

  • Smith S. G. and Davis W. N. (1974) Intravenous alcohol self-administration in the rat. Pharmacol. Res. Commun. 6, 397–401.

    Article  Google Scholar 

  • Smith S. G., Werner T. E., and Davis W. M. (1976) Comparison between intravenous and intragastric alcohol self-administration. Physiol. Psychol. 4, 91–93.

    Google Scholar 

  • Staats J. (1966) The inbred mouse, in Biology of the Laboratory Mouse, Green E. L., ed., McGraw Hill, New York, pp. 1–11.

    Google Scholar 

  • Stewart R. B. and Grupp L. A. (1984) A simplified procedure for producing ethanol self-selection in rats. Pharmacol. Biochem. Behav. 21, 255–258.

    Article  PubMed  CAS  Google Scholar 

  • Stewart R. B. and Grupp L. A. (1988) Conditioned place aversion mediated by orally self-administered ethanol in the rat: A consideration of blood ethanol levels. Pharmacol. Biochem. Behav. 32, 331–371.

    Google Scholar 

  • Stewart R. B., Perlanski E., and Grupp L. A. (1988) Ethanol as a reinforcer for rats: Factors of facilitation and constraint. Alcoholism: Clin. Exp. Res 12, 599–608.

    Article  CAS  Google Scholar 

  • Suzuki T., George, F. R., and Meisch R. A. (1988) Differential establishment and maintenance of oral ethanol reinforced behavior in Lewis and Fischer 344 inbred rat strains. J. Pharmacol. Exp. Ther. 245, 164–170.

    PubMed  CAS  Google Scholar 

  • Veale W. L. and Myers R. D. (1969) Increased alcohol preference in rats following repeated exposures to alcohol. Psychopharmacologia (Berl.) 15, 361–372.

    Article  CAS  Google Scholar 

  • Waller M. B., McBride W. J., Gatto G. J., Lumeng L., and Li T.-K. (1984) Intragastric self-infusion of ethanol by the P and NP (alcohol-preferring and-nonpreferring) lines of rats. Science 225, 78–80.

    Article  PubMed  CAS  Google Scholar 

  • Waller M. B., McBride W. J., Lumeng L., and Li T.-K. (1982) Induction of dependence on ethanol by free-choice drinking in alcohol preferring rats. Pharmacol. Biochem. Behav. 16, 501–507.

    Article  PubMed  CAS  Google Scholar 

  • Waller M. B., McBride W. J., Lumeng L., and Li T.-K. (1983) Initial sensitivity and acute tolerance to ethanol in the P and NP lines of rats. Pharmacol. Biochem. Behav. 19, 683–686.

    Article  PubMed  CAS  Google Scholar 

  • Waller M. B., Murphy J. M., McBride W. J., Lumeng L., and Li T.-K. (1986) Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and-nonpreferring lines of rats. Pharmacol. Biohem. Behav. 24, 617–625.

    Article  CAS  Google Scholar 

  • Wallgren H. and Barry H. III (1970) Actions of Alcohol. Elsevier, Amsterdam.

    Google Scholar 

  • Wayner M. J., Greenberg I., Tartaglione R., Nolley D., Fraley S., and Cott A. (1972) A new factor affecting the consumption of ethyl alcohol and other sapid fluids. Physiol. Behav. 8, 345–362.

    Article  PubMed  CAS  Google Scholar 

  • Westerfield W. W. and Lawrow J. (1953) The effect of caloric restriction and thiamin deficiency on the voluntary consumption of alcohol by rats. Q. J. Stud. Alc. 14, 378–384

    Google Scholar 

  • Wise R. A. (1973) Voluntary ethanol intake in rats following exposure to ethanol on various schedules. Psychopharmacologia (Berl) 29, 203–210.

    Article  CAS  Google Scholar 

  • Wise R. A. (1980) Action of drugs of abuse on brain reward systems. Pharmacol. Biochem. Behav. 13, 213–223.

    PubMed  Google Scholar 

  • Woods J. H., Young A. M., and Winger G. (1971) The reinforcing property of ethanol, in Biological Aspects of Alcohol. Advances in Mental Science, vol. 3, Roach M. K., McIsaac W., and Creaven R. T., eds., University of Texas Press, Austin, pp. 371–387.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, University of Texas Mental Sciences Institute, Houston, TX

    Robert B. Stewart

  2. Addiction Research Foundation, Toronto, and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada

    Larry A. Grupp

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  1. Robert B. Stewart
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  2. Larry A. Grupp
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Editor information

Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  2. University of Alberta, Edmonton, Canada

    Glen B. Baker

  3. University of Toronto, Toronto, Canada

    Peter H. Wu

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Stewart, R.B., Grupp, L.A. (1992). Models of Alcohol Consumption Using the Laboratory Rat. In: Boulton, A.A., Baker, G.B., Wu, P.H. (eds) Animal Models of Drug Addiction. Neuromethods, vol 24. Humana Press. https://doi.org/10.1385/0-89603-217-5:1

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  • DOI: https://doi.org/10.1385/0-89603-217-5:1

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-217-0

  • Online ISBN: 978-1-59259-629-4

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