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Protocols in Molecular Neurobiology pp 307–323Cite as

Identification of a Ligand-Gated Ion Channel by Photoaffinity Labeling and Microsequencing

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 13))

Abstract

It is generally agreed that ion channels are operationally composed of two functional domains: The selectivity filter comprises the part of the protein that determines which ion may pass and which is retained; the gate determines under which conditions the selected ions may pass. Named according to the mechanisms that regulate the gate, the two groups of ion channels are today known as the ligandgated and the voltagegated channels.

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Author information

Authors and Affiliations

  1. Fachbereich Chemie, Institut fur Biochie, Freie Universitat Berlin, Berlin, Germany

    Ferdinand Hucho

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  1. Ferdinand Hucho
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Editor information

Editors and Affiliations

  1. University of Hertfordshire, Hatfield, UK

    Alan Longstaff

  2. King’s College, University of London, UK

    Patricia Revest

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© 1992 The Humana Press, Totowa, NJ

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Hucho, F. (1992). Identification of a Ligand-Gated Ion Channel by Photoaffinity Labeling and Microsequencing. In: Longstaff, A., Revest, P. (eds) Protocols in Molecular Neurobiology. Methods in Molecular Biology™, vol 13. Springer, Totowa, NJ. https://doi.org/10.1385/0-89603-199-3:307

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  • DOI: https://doi.org/10.1385/0-89603-199-3:307

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-0-89603-199-9

  • Online ISBN: 978-1-59259-500-6

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