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Immortalization of Human B-Lymphocytes by Epstein-Barr Virus

  • Paul M. Brickell
Part of the Methods in Molecular Biology book series (MIMB, volume 8)

Abstract

Epstein-Barr virus (EBV) is able to immortalize human B-lymphocytes with high efficiency. This property underlies the role of EBV in a number of human diseases. First, EBV is the causative agent of infectious mononucleosis, which is a benign proliferation of B-lymphocytes (1). Second, EBV is involved in the etiology of Burkitt’s lymphoma (2) and of invasive B-lymphocyte proliferations found in immunosuppressed individuals (3).

Keywords

Fetal Calf Serum Latent Membrane Protein Infectious Mononucleosis Immunosuppressed Individual Viral Gene Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc., Clifton, NJ 1991

Authors and Affiliations

  • Paul M. Brickell
    • 1
  1. 1.Medical Molecular Biology UnitUniversity College and Middlesex School of MedicineLondonUK

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