Time-Lapse Cinemicroscopy

  • Peter N. Riddle
Part of the Methods in Molecular Biology book series (MIMB, volume 5)


Cinematography commenced as a scientific technique used as a system for “slowing down” observed movement. Marey in 1888 (1) constructed, following a number of other ideas, a “Chambre Chronophoto-graphique,” which had practically all the elements of the modern cine camera. With this he made serial photographs (not transparencies) of various biological phenomena (2).


Hair Dryer Special Chamber Field Stop Camera Shutter Film Speed 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Marey, E. J. (1894) Le Mouvement (Masson, G., ed.), Paris.Google Scholar
  2. 2.
    Michaelis, A. R. (1955) Research Films in Biology, Anthropology, Psychology, and Medicine (Academic Press, New York).Google Scholar
  3. 3.
    See J. James (1976) Light Microscopy Techniques in Biology and Medicine, Martinus Nijhoff Medical Division, Netherlands, pp. 151, 152.Google Scholar
  4. 4.
    Richmond, K. M. V., Riddle, P. N., and Brooks, R. F. (1984) Apparent desensitization of Swiss 3T3 cells to the mitogens FGF and vasopressin. J. Cell Physiol. 121, 547–557.PubMedCrossRefGoogle Scholar
  5. 5.
    Wilkinson, C. and Lackie, J. M. (1983) The influence of contact guidance on chemo-taxis of human neutrophil leukocytes. Exp. Cell Res. 145, 255–264.PubMedCrossRefGoogle Scholar
  6. 6.
    O’Neill, C. H., Riddle, P. N., and Rozengurt, E. (1985) Stimulating the proliferation of quiescent 3T3 fibroblasts by peptide growth factors or by agents that elevate cellular cyclic AMP level has opposite effects on motility. Exp. Cell Res. 156, 65–78.PubMedCrossRefGoogle Scholar
  7. 7.
    Lackie, J. M. (1986) Cell Movement and Cell Behavior (Allen and Unwin, London, Boston, and Sydney).Google Scholar
  8. 8.
    Brooks, R. F., Riddle, P. N., Richmond, F. N., and Marsden, J. (1983) The Gl distribution of “Gl-less“ V79 Chinese hamster cells. Exp. Cell Res. 148, 127–142.PubMedCrossRefGoogle Scholar
  9. 9.
    Salmon, E. D. and Ellis, G. W. (1975) A new miniature hydrostatic pressure chamber for microscopy. J. Cell Biol. 65, 587–602.PubMedCrossRefGoogle Scholar
  10. 10.
    Riddle, P. N. (1979) Time-Lapse dnemicroscopy (Traherne, J. E. and Rubery, P. H., eds.), Academic Press, London and New York.Google Scholar
  11. 11.
    Roberts, D. C. and Trevan, D. J. (1961) A versatile microscope chamber for the study of environmental changes on living cells. J. R. Microsc. Soc. 79, 361–366.PubMedGoogle Scholar
  12. 12.
    Riddle, P. N. (1983) A device for demisting Petri dishes. Lab. Practice 32, 80.Google Scholar
  13. 13.
    Riddle, P. N. (1977) Beam deflection as an alternative to light shuttering in cinemi-croscopy. Lab. Practice 26, 865.Google Scholar
  14. 14.
    Trevan, D. J. (1961) A simple inverted microscope for use with a cine camera. J. R. Microsc. Soc. 79, 367, 368.PubMedGoogle Scholar
  15. 15.
    Riddle, P. N. (1974) Comparison cinemicrographs prepared by optical split screen printing, Report of 2nd International Colloquium ofInterkamers’ 73 (Serb, V. and Sibalova, J., eds.), In Vitro vs CSSR Hradci Kralove.Google Scholar
  16. 16.
    Brooks, R. F. and Riddle, P. N. (1988) Differences in growth factor sensitivity between individual 3T3 cells arise at high frequency: possible relevance to cell senescence. Exp. Cell Res. 174, 378–388.PubMedCrossRefGoogle Scholar
  17. 17.
    Small, R. K., Riddle, P. N., and Noble, M. (1987) Evidence for the migration of oligo-dendrocyte-type-2 astrocyte progenitor cells into the developing rat optic nerve. Nature 328, 155–157.PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1990

Authors and Affiliations

  • Peter N. Riddle
    • 1
  1. 1.Imperial Cancer Research FundLondonUK

Personalised recommendations