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Psychopharmacology pp 513–563Cite as

Discrimination Learning with Drug Stimuli

Methods and Applications

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Part of the book series: Neuromethods ((NM,volume 13))

Abstract

It is the intent of this chapter to selectively review data pertaining to the phenomenon of drug-discrimination learning (DDL), i.e., discriminative control of behavior by drug states. A related phenomenon is state-dependent learning (SDL), i.e., the observation that a behavior learned in one particular state is not easily retrievable unless the state present during the initial learning episode is reinstated. Colpaert (1977)13 argued that DDL and SDL are different phenomena, whereas others assume that both phenomena basically reflect the same properties of drugs, intensity (i.e., dose) being a major factor (Järbe, 1986 67, 1987 68).

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References

  1. Altman J. L., Albert J-M., Milstein S., and Greenberg I. (1977) Drugs as Discriminable Events in Humans, in Discriminative Stimulus Properties of Drugs (Lai H., ed.) Plenum, New York.

    Google Scholar 

  2. Ator N. A. and Griffiths R. R. (1983) Lorazepam and pentobarbital drug discrimination in baboons Cross-drug generalization and interaction with Ro 15-1788. J. Pharmacol. Exp. Ther. 226, 776–778.

    PubMed  CAS  Google Scholar 

  3. Barrett R. J. and Leigh N. J. (1981) Tolerance to the discriminative stimulus properties of d-amphetamine. Neuropharmacology 20, 251–255.

    PubMed  CAS  Google Scholar 

  4. Barrett R. J. and Steranka L. R. (1983) Drug discrimination in rats: Evidence for amphetamine-like cue state following chronic haloperidol. Pharmacol. Biochem. Behav. 18, 611–617.

    PubMed  CAS  Google Scholar 

  5. Barrett R. J., Blackshear M. A., and Sanders-Bush E. (1982) Discriminative stimulus properties of l-5-hydroxy-tryptophan: Behavioral evidence for multiple serotonin receptors. Psychopharmacology 76, 29–35.

    PubMed  CAS  Google Scholar 

  6. Barry H., III. (1974) Classification of drugs according to their discriminable effects in rats. Fed. Proc. 33, 1814–1824.

    PubMed  CAS  Google Scholar 

  7. Bertalmio A. J., Herling S., Hampton R. Y., Winger G., and Woods J. H. (1982) A procedure for rapid evaluation of the discriminative stimulus effects of drugs. J. Pharmacol. Meth. 7, 289–299.

    CAS  Google Scholar 

  8. Brady J. W. and Fischman M. W. (1985) Assessment of Drugs for Dependence Potential and Abuse Liability: An Overview, in Behavioral Pharmacology: The Current Status (Seiden L. S. and Balster R. L., eds.) Alan R. Liss, New York.

    Google Scholar 

  9. Brown A., Feldman R. S., and Moore J. W. (1968) Conditional discrimination learning based on chlordiazepoxide: Dissociation or cue? J. Comp. Physiol. Psychol. 66, 211–215.

    PubMed  CAS  Google Scholar 

  10. Carter R. B, and Leander J. D. (1982) Discriminative stimulus properties of naloxone. Psychopharmacology 77, 305–308.

    PubMed  CAS  Google Scholar 

  11. Catania A. C. (1971) Discriminative Stimulus Functions of Drugs: Interpretations, in Stimulus Properties of Drugs (Thompson T. and Pickens R., eds.) Appleton-Century-Crofts, New York.

    Google Scholar 

  12. Chait L. D., Uhlenhuth E. H., and Johanson C. E. (1984) An experimental paradigm for studying the discriminative stimulus properties of drugs in humans. Psychopharmacology 82, 272–274.

    PubMed  CAS  Google Scholar 

  13. Colpaert F. C. (1977) Drug-Produced Cues and States: Some Theoretical and Methodological Inferences, in Discriminative Stimulus Properties of Drugs (Lai H., ed.) Plenum, New York.

    Google Scholar 

  14. Colpaert F. C. (1982) The Pharmacological Specificity of Opiate Drug Discrimination, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert F. C. and Slangen J. L., eds.) Elsevier, Amsterdam.

    Google Scholar 

  15. Colpaert F. C. and Janssen P. A. J. (1982a) Factors regulating drug cue sensitivity: Limits of discriminability and the role of progressively decreasing training dose in cocaine-saline discrimination. Neuropharmacology 21, 1187–1194.

    PubMed  CAS  Google Scholar 

  16. Colpaert F. C. and Janssen P. A. J. (1982b) Factors regulating drug cue sensitivity: The effects of dose ratio and absolute dose level in the case of fentanyl dose-dose discrimination. Arch. Int. Pharmacodyn. Ther. 258, 283–299.

    PubMed  CAS  Google Scholar 

  17. Colpaert F. C. and Janssen P. A. J. (1981) Factors regulating drug cue sensitivity: The effect of frustrative non-reward in fentanyl-saline discrimination. Arch. Int. Pharmacodyn. Ther. 254, 241–251.

    PubMed  CAS  Google Scholar 

  18. Colpaert F. C. and Rosecrans J. A., eds. (1978) Stimulus Properties of Drugs: Ten Years of Progress Elsevier, Amsterdam.

    Google Scholar 

  19. Colpaert F. C. and Slangen J. L., eds. (1982) Drug Discrimination: Applications in CNS Pharmacology Elsevier, Amsterdam.

    Google Scholar 

  20. Colpaert F. C, Maroli A. N., and Meert T. (1982) Parametric effects in the discrimination of intracranial stimulation: Some methodological and analytical issues. Physiol. Behav. 28, 1047–1058.

    PubMed  CAS  Google Scholar 

  21. Colpaert F. C., Kuyps J. J. M. P., Niemeegers C. J. E., and Janssen P. A. J. (1976a) Discriminative stimulus properties of a low d,l-amphetamine dose. Arch. Int. Pharmacodyn. Ther. 223, 34–42.

    PubMed  CAS  Google Scholar 

  22. Colpaert F. C, Kuyps J. J., Niemeegers C. J. E., and Janssen P. A. J. (1976b) Discriminative stimulus properties of fentanyl and morphine: Tolerance and dependence. Pharmacol. Biochem. Behav. 5, 401–408.

    PubMed  CAS  Google Scholar 

  23. Colpaert F. C, Niemeegers C. J. E., and Janssen P. A. J. (1976c) Theoretical and methodological considerations on drug discrimination learning. Psychopharmacologia 46, 169–177.

    PubMed  CAS  Google Scholar 

  24. Colpaert F. C, Niemeegers C. J. E., and Janssen P. A. J. (1978a) Studies on the regulation of sensitivity to the narcotic cue. Neuropharmacology 17, 705–713.

    PubMed  CAS  Google Scholar 

  25. Colpaert F. C, Niemegeers C. J. E., and Janssen P. A. J. (1978b) Factors Regulating Drug Cue Sensitivity. A Long-Term Study on the Cocaine Cue, in Stimulus Properties of Drugs: Ten Years of Progress (Colpaert F. C. and Rosecrans J. A., eds.) Elsevier, Amsterdam.

    Google Scholar 

  26. Colpaert F. C, Niemeegers C. J. E., and Janssen P. A. J. (1978c) Drug-cue conditioning to external stimulus conditions Eur. J. Pharmacol. 49, 185–188.

    PubMed  CAS  Google Scholar 

  27. Colpaert F. C, Niemegeers C. J. E., and Janssen P. A, J. (1980a) Factors regulating drug cue sensitivity: Limits of discriminability and the role of a progressively decreasing training dose in fentanyl-saline discrimination. J. Pharmacol. Exp. Ther. 212, 474–480.

    PubMed  CAS  Google Scholar 

  28. Colpaert F. C, Niemegeers C. J. E., and Janssen P. A. J. (1980b) Factors regulating drug cue sensitivity: The effect of training dose in fentanyl-saline discrimination. Neuropharmacology 19, 705–713.

    PubMed  CAS  Google Scholar 

  29. DeVry J., Koek W., and Slangen J. L. (1984) Effects of drug-induced differences in reinforcement frequency on discriminative stimulus properties of fentanyl. Psychopharmacology 83, 257–261.

    CAS  Google Scholar 

  30. De Witte P. (1978) Hierarchy on the Perceptual Dimensions of Hypothalamic Stimulation: The Psychophysics of Rewarding Cues, and Effects of Sensory Stimulation on Self-Stimulation, in Stimulus Properties of Drugs: Ten Years of Progress (Colpaert F. C. and Rosecrans J. A., eds.) Elsevier, Amsterdam.

    Google Scholar 

  31. De Witte P. H. (1982) Brain stimulation as the reinforcer in alcohol-saline discrimination. Pharmacol. Biochem. Behav. 17, 1093–1096.

    PubMed  Google Scholar 

  32. De Witte P. H. and Gewiss M. (1986) Effects of variations of reinforcement magnitude on alcohol discrimination using intracranial stimulation as the reinforcer. Physiol. Behav. 36, 1005–1008.

    PubMed  Google Scholar 

  33. D’Mello G. D. (1981) A comparison of some behavioural effects of amphetamine and electrical brain stimulation of the mesolimbic dopamine system in rats. Psychopharmacology 75, 184–192.

    CAS  Google Scholar 

  34. Downey D. J. (1975) State dependent learning with centrally and noncentrally active drugs. Bull. Psychon. Soc. 5, 281–284.

    Google Scholar 

  35. Emmett-Oglesby M. W., Harris C. M., Lane J. D., and Lai H. (1984) Withdrawal from morphine generalizes to a pentylenetetrazol stimulus. Neuropeptides 5, 37–40.

    PubMed  CAS  Google Scholar 

  36. Emmett-Oglesby M. W., Spencer D. G., Jr., Elmesallamy F., and Lai H. (1983a) The pentylenetetrazol model of anxiety detects withdrawal from diazepam in rats. Life Sci. 33, 161–168.

    PubMed  CAS  Google Scholar 

  37. Emmett-Oglesby M. W., Wurst M., and Lai H. (1983b) Discriminative stimulus properties of a small dose of cocaine. Neuropharmacology 22, 97–101.

    PubMed  CAS  Google Scholar 

  38. Extance K. and Goudie A. J. (1981) Inter-animal olfactory cues in operant drug discrimination procedures in rats. Psychopharmacology 73, 363–371.

    PubMed  CAS  Google Scholar 

  39. Ferster C. B. and Skinner B. F. (1957) Schedules of Reinforcement Appleton-Century-Crofts, New York.

    Google Scholar 

  40. France C. P. and Woods J. H. (1985) Opiate agonist-antagonist interactions: Application of a three-key drug discrimination procedure. J. Pharmacol. Exp. Ther. 234, 81–89.

    PubMed  CAS  Google Scholar 

  41. Frey L. G. and Winter J. C. (1978) Current Trends in the Study of Drugs and Discriminative Stimuli, in Drug Discrimination and State Dependent Learning (Ho B. T., Richards III, D. W., and Chute D. L., eds.) Academic, New York.

    Google Scholar 

  42. Gaiardi M., Bartoletti M., Gubellini C, Bacchi A., and Babbini M. (1986) Sensitivity to the narcotic cue in nondependent, morphine-dependent and post-dependent rats. Neuropharmacology 25, 119–123.

    PubMed  CAS  Google Scholar 

  43. Gellert V. F. and Holtzman S. G. (1979) Discriminative stimulus effects of naltrexone in the morphine-dependent rat. J. Pharmacol. Exp. Ther. 211, 596–605.

    PubMed  CAS  Google Scholar 

  44. Gilbert P. E. and Martin W. R. (1976) The effects of morphine-and nalorphine-like drugs in the non-dependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 198, 66–82.

    PubMed  CAS  Google Scholar 

  45. Glennon R. A., Rosecrans J. A., and Young R. (1982) The Use of the Drug Discrimination Paradigm for Studying Hallucinogenic Agents. A Review, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert F. C. and Slangen J. L., eds.) Elsevier, Amsterdam.

    Google Scholar 

  46. Gouvier W. M. D., Akins F. R., and Trapold M. A. (1984) Assessment of drug state dimensionality via drug-drug training and stimulus generalization testing. Pharmacol. Biochem. Behav. 21, 687–693.

    PubMed  CAS  Google Scholar 

  47. Griffiths R. R., Roache J. D., Ator N. A., Lamb R. J., and Lukas S. E. (1985) Similarities in Reinforcing and Discriminative Stimulus Effects of Diazepam, Triazolam, and Pentobarbital in Animals and Humans, in Behavioral Pharmacology: The Current Status (Seiden L. S. and Balster R. L., eds.) Alan R. Liss, New York.

    Google Scholar 

  48. Harris R. T. and Balster R. L. (1970) An Analysis of Psychological Dependence, in Drug Dependence (Harris R. T., Mclsaac W. M., and Schuster C. R., eds.) University of Texas Press, Austin.

    Google Scholar 

  49. Haug T. and Götestam K-G. (1980) Reinforcing, discriminative and activating properties of amphetamine. Addict. Behav. 5, 199–208.

    PubMed  CAS  Google Scholar 

  50. Haug T. and Gotestam K-G. (1982) Onset and offset of the diazepam stimulus complex. Pharmacol. Biochem. Behav. 17, 1171–1174.

    PubMed  CAS  Google Scholar 

  51. Heinemann E. G. and Chase S. (1975) Stimulus Generalization, in Conditioning and Behavior Theory (Estes W. K., ed.) LEA, Hillsdale.

    Google Scholar 

  52. Herling S. and Shannon H. E. (1982) Ro 15-1788 antagonizes the discriminative stimulus effects of diazepam in rats but not similar effects of pentobarbital. Life Sci. 31, 2105–2112.

    PubMed  CAS  Google Scholar 

  53. Herling S. and Woods J. H. (1981) Discriminative stimulus effects of narcotics: Evidence for multiple receptor-mediated actions. Life Sci. 28, 1571–1584.

    PubMed  CAS  Google Scholar 

  54. Hiltunen A. J. and Jarbe T. U. C. (1986a) Interactions between Δ9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons. Neuropharmacology 25, 133–142.

    PubMed  CAS  Google Scholar 

  55. Hiltunen A. J. and Jarbe T. U. C. (1986b) Discrimination of Ro 11-6896, chlordiazepoxide, and ethanol in gerbils: Generalization and antagonism tests. Psychopharmacology 89, 284–290.

    PubMed  CAS  Google Scholar 

  56. Hiltunen A. J. and Järbe, T. U. C. (1986c) Cannabidiol attenuates Δ9-tetrahydrocannabinol like discriminative stimulus effects of cannabinol. Eur. J. Pharmacol. 125, 301–304.

    PubMed  CAS  Google Scholar 

  57. Hirschhorn I. D. and Rosecrans J. A. (1974) Morphine and delta-9-tetrahydrocannabinol: Tolerance to the stimulus effects. Psychopharmacologia 36, 243–253.

    PubMed  CAS  Google Scholar 

  58. Ho B. T., Richards W. III, and Chute D. L., eds (1978) Drug Discrimination and State Dependent Learning Academic, New York.

    Google Scholar 

  59. Holtzman S. G. (1979) Discriminative stimulus properties of levo-alpha-acethylmethadol and its metabolites. Pharmacol. Biochem. Behav. 10, 565–568.

    PubMed  CAS  Google Scholar 

  60. Holtzman S. G. (1985a) Discriminative Stimulus Properties of Opioids that Interact with Mu, Kappa and PCP/Sigma Receptors, in Behavioral Pharmacology: The Current Status (Seiden L. S. and Balster R. L., eds.) Alan R. Liss, New York.

    Google Scholar 

  61. Holtzman S. G. (1985b) Discriminative stimulus effects of morphine withdrawal in the dependent rat: Suppression by opiate and nonopiate drugs. J. Pharmacol. Exp. Ther. 233, 80–86.

    PubMed  CAS  Google Scholar 

  62. Honig W. K. and Urcuioli P. J. (1981) The legacy of Gutman and Kahsh (1956); 25 years of research on stimulus generalization. J. Exp. Anal. Behav. 36, 405–445.

    PubMed  CAS  Google Scholar 

  63. Hutchings G. C, Gonzalez L. P., and Altshuler H. L. (1978) Changes in cocaine discrimination in rats during chronic cocaine exposure. Fed. Proc. 31, 274.

    Google Scholar 

  64. Järbe T. U. C. (1976) Characteristics of pentobarbital discrimination in the gerbil: Transfer and antagonism. Psychopharmacology 49, 33–40.

    PubMed  Google Scholar 

  65. Järbe T. U. C. (1981) Cocaine cue in pigeons: Time-course studies and generalization to structurally related compounds (norcocaine, WIN 35, 428, and 35,065-2) and, d-amphetamine. Br. J. Pharmacol. 73, 843–852.

    PubMed  Google Scholar 

  66. Järbe T. U. C. (1984) Discriminative stimulus properties of cocaine: effects of apomorphine, haloperidol, procaine, and other drugs. Neuropharmacology 23, 899–907.

    PubMed  Google Scholar 

  67. Järbe T. U. C. (1987) Drug Discrimination Learning: Cue Properties of Drugs, in Experimental Psychopharmacology (Greenshaw A. and Dourish C. T., eds.) Humana, Clifton, New Jersey.

    Google Scholar 

  68. Järbe T. U. C. (1986) State-dependent learning and drug discriminative control of behaviour: An overview. Acta Neurol. Scand. 74,(suppl. 109), 37–59.

    Google Scholar 

  69. Järbe T. U. C. and Hiltunen A. J. (1987) Cannabimimetic activity of cannabinol in rats and pigeons. Neuropharmacology 26, 219–228.

    PubMed  Google Scholar 

  70. Järbe T. U. C, and Holmgren B. (1977) Discriminative properties of pentobarbital after repeated, noncontingent exposure in gerbils. Psychopharmacology 53, 39–44.

    PubMed  Google Scholar 

  71. Järbe T. U C. and Johansson B. (1984) Interaction between drug discriminative stimuli and exteroceptive signals. Behav. Neurosci. 98, 686–694.

    PubMed  Google Scholar 

  72. Järbe T. U. C. and Johansson J. O. (1976) Drug discrimination in rats: Effects of mixtures of ditran and cholinesterase inhibitors. Pharmacol. Biochem. Behav. 4, 151–157.

    PubMed  Google Scholar 

  73. Järbe T. U. C. and McMillan, D. E. (1980) Δ9-THC as a discriminative stimulus in rats and pigeons: Generalization to THC-metabolites and SP-111. Psychopharmacology 71, 281–289.

    PubMed  Google Scholar 

  74. Järbe T. U. C. and McMillan D. E. (1983) Interaction of the discriminative stimulus properties of diazepam and ethanol in pigeons. Pharmacol. Biochem. Behav. 18, 73–80.

    PubMed  Google Scholar 

  75. Järbe T. U. C. and Ohlin G. C. (1979) Discriminative effects of combinations of Δ9-tetrahydrocannabinol and pentobarbital in pigeons. Psychopharmacology 63, 233–239.

    PubMed  Google Scholar 

  76. Järbe T. U. C. and Rollenhagen C. (1978) Morphine as a discriminative cue in gerbils: Drug generalization and antagonism. Psychopharmacology 58, 271–275.

    PubMed  Google Scholar 

  77. Järbe T. U. C. and Swedberg M. D. B. (1981) Differences in the stimulus effects of CNS depressant drugs as evidenced by drug vs drug discrimination techniques. Acta Pharmacol. Toxicol. 49,(suppl. IV), abstract 45.

    Google Scholar 

  78. Järbe T. U. C. and Swedberg M. D. B. (1982a) Discriminative stimulus properties of drugs: A brief history and a selective review. Scand. J. Psychol. (suppl. 1), 72–78.

    Google Scholar 

  79. Järbe T. U. C. and Swedberg M. D. B. (1982b) A Conceptualization of Drug Discrimination Learning, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert F. C. and Slangen J. L., eds.) Elsevier, Amsterdam.

    Google Scholar 

  80. Järbe T. U. C, Henriksson B. G., and Ohlin G. C. (1977) Δ9-THC as a discriminative cue in pigeons: Effects of Δ8-THC, CBD, and CBN. Arch. Int. Pharmacodyn. Ther. 228, 68–72.

    PubMed  Google Scholar 

  81. Järbe T. U. C, Svensson R., Hiltunen A.J., and Swedberg M. D. B. (1985) Drug discrimination learning and its reversal. Acta Pharmacol. Toxicol. 57,(suppl. 1), abstract 24.

    Google Scholar 

  82. Järbe T. U. C, Loman P., and Swedberg M. D. B. (1979) Evidence supporting lack of discriminative stimulus properties of a combination of naltrexone and morphine. Pharmacol. Biochem. Behav. 10, 493–497.

    PubMed  Google Scholar 

  83. Järbe T. U. C, Laaksonen T., and Svensson R. (1983a) Influence of external stimulus conditions upon internal drug stimulus control. Psychopharmacology 80, 31–34.

    PubMed  Google Scholar 

  84. Järbe T. U. C, Svensson R., and Laaksonen T. (1983b) Conditioning of a discriminative drug stimulus: Overshadowing and blocking like procedures. Scand. J. Psychol. 24, 325–330.

    PubMed  Google Scholar 

  85. Järbe T. U. C, Swedberg M. D. B., and Mechoulam R. (1981a) A repeated tests procedure to assess onset and duration of the cue properties of (−)-Δ9-THC, (−)Δ8-THC-DMH and (+)-Δ8-THC. Psychopharmacology 75, 152–157.

    PubMed  Google Scholar 

  86. Järbe T. U. C, Sterner U., and Hjerpe C. (1981b) Conditioning of an interoceptive drug stimulus to different exteroceptive contexts. Psychopharmacology 73, 23–26.

    PubMed  Google Scholar 

  87. Järbe T. U. C, Swedberg M. D. B., and Hiltunen A. J. (1984) Conditioning of drug discriminative stimuli—ethanol and pentobarbital. Acta Pharmacol. Toxicol. 55,(suppl. I), abstract 6.

    Google Scholar 

  88. Johansson J. O. and Jarbe T. U. C. (1975a) Antagonism of pentobarbital induced discrimination in the gerbil. Psychopharmacologia 41, 225–228.

    PubMed  CAS  Google Scholar 

  89. Johansson J. O. and Jarbe T. U. C. (1975b) Diazepam as a discriminative cue: Its antagonism by bemegride. Eur. J. Pharmacol. 30, 372–375.

    PubMed  CAS  Google Scholar 

  90. Johansson J. O. and Jarbe T. U. C. (1976) Physostigmine as a discriminative cue in rats. Arch. Int. Pharmacodyn. Ther. 219, 97–102.

    PubMed  CAS  Google Scholar 

  91. Kallman W. M., Kallman M. J., Harry G. J., Woodson P. P., and Rosecrans J. A. (1982) Nicotine as a Discriminative Stimulus in Human Subjects, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert F. C. and Slangen J. L., eds.) Elsevier, Amsterdam.

    Google Scholar 

  92. Kilbey M. M., Harris R. T., and Aigner T. G. (1971) Establishment of equivalent external and internal stimulus control of an operant behavior and its reversal. Proc. Am. Psychol. Assoc. 6, 767–768.

    Google Scholar 

  93. Koek W. and Slangen J. L. (1982) Drug Stimulus Generalization in the Absence of Discrimination Training, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert F. C. and Slangen, J. L., eds.), Elsevier, Amsterdam.

    Google Scholar 

  94. Koek W. and Slangen J. L. (1984) External stimulus control in a “drug-discrimination” procedure: Drug effects and inter-animal variation. Psychopharmacology 82, 168–173.

    PubMed  CAS  Google Scholar 

  95. Krimmer E. C. and Barry III, H. (1979) Pentobarbital and chlordiazepoxide differentiated from each other and from nondrug. Commun. Psychopharmacol. 3, 93–99.

    PubMed  CAS  Google Scholar 

  96. Krimmer E. C, Benson B. J., McGuire M., Barry III, H. (1982) Conditional Sensory Stimuli During Morphine Discrimination, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert F. C. and Slangen J. L., eds.) Elsevier, Amsterdam.

    Google Scholar 

  97. Lal H., ed. (1977a) Discriminative Stimulus Properties of Drugs Plenum, New York.

    Google Scholar 

  98. Lal H. (1977b) Drug Induced Discriminable Stimuli: Past Research and Future Perspectives, in Discriminative Stimulus Properties of Drugs (Lal H, ed.) Plenum, New York.

    Google Scholar 

  99. Lal H. and Fielding S. (1984) Antagonism of discriminative stimuli produced by anxiogenic drugs as a novel approach to bioassay anxiolytics. Drug Dev. Res. 4, 3–21.

    CAS  Google Scholar 

  100. Lal H. and Yaden S. (1985) Discriminative stimuli produced by clonidine in spontaneously hypertensive rats: Generalization to antihypertensive drugs with different mechanisms of action. J. Pharmacol. Exp. Ther. 232, 33–39.

    PubMed  CAS  Google Scholar 

  101. Martin W. R., Eades C. G., Thompson J. A., Huppler R. E., and Gilbert P. E. (1976) The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther 197, 517–532.

    PubMed  CAS  Google Scholar 

  102. McKenna M. and Ho B. T. (1977) Induced tolerance to the discriminative stimulus properties of cocaine. Pharmacol. Biochem. Behav. 7, 273–276.

    PubMed  CAS  Google Scholar 

  103. McMillan D. E. (1982) Generalization of the discriminative stimulus properties of phencyclidine to other drugs in the pigeon using color tracking under second order schedules. Psychopharmacology 78, 131–134.

    PubMed  CAS  Google Scholar 

  104. McMillan D. E. and Wenger G. R. (1984) Bias of phencyclidine discrimination by the schedule of reinforcement. J. Exp. Anal. Behav. 42, 51–66.

    PubMed  CAS  Google Scholar 

  105. McMillan D. E., Cole-Fullenwider D. A., Hardwick W. C., and Wenger G. R. (1982) Phencyclidine discrimination in the pigeon using color tracking under second-order schedules. J. Exp. Anal. Behav. 37, 143–147.

    PubMed  CAS  Google Scholar 

  106. Miksic S. and Lal H. (1977) Tolerance to morphine produced stimuli and analgesia. Psychopharmacology 54, 217–221.

    PubMed  CAS  Google Scholar 

  107. Modrow H. E. and Holloway F. A. (1985) Drug discrimination and cross generalization between two methylxanthines. Pharmacol. Biochem. Behav. 23, 425–429.

    PubMed  CAS  Google Scholar 

  108. Modrow H. E., Petroff K. S. R., and Bliss D. K. (1978) Physiological Substrates of State-Dependent Learning, in Stimulus Properties of Drugs: Ten Years of Progress (Colpaert F. C. and Rosecrans J. A., eds.) Elsevier, Amsterdam.

    Google Scholar 

  109. Mokler D. J., Nelson B. D., Harris L. S., and Rosecrans J. A. (1986) The role of benzodiazepine receptors in the discriminative stimulus properties of delta-9-tetrahydrocannabinol. Life Sci. 38, 1581–1589.

    PubMed  CAS  Google Scholar 

  110. Nichols D. E. and Glennon R. A. (1984) Medicinal Chemistry and Structure-Activity Relationships of Hallucinogens, in Hallucinogens: Neurochemical, Behavioral, and Clinical Perspectives (Jacobs B. L., ed.) Raven, New York.

    Google Scholar 

  111. Nielsen E. B. and Jepsen J. A. (1985) Antagonism of the amphetamine cue by both classical and atypical antipsychotic drugs. Eur. J. Pharmacol. 111, 167–176.

    PubMed  CAS  Google Scholar 

  112. Nielsen, E. B. and Scheel-Krüger J. (1986) Cueing effects of amphetamine and LSD: Elicitation by direct microinjection of the drugs into the nucelus accumbens. Eur. ]. Pharmacol. 125, 85–92.

    CAS  Google Scholar 

  113. Overton D. A. (1966) State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia 10, 6–31.

    PubMed  CAS  Google Scholar 

  114. Overton D. A. (1971) Discriminative Control of Behavior by Drug States, in Stimulus Properties of Drugs (Thompson T. and Pickens R., eds.) Appleton-Century Crofts, New York.

    Google Scholar 

  115. Overton D. A. (1973) State-Dependent Learning Produced by Addicting Drugs, in Opiate Addiction: Origins and Treatment (Fisher S. and Freedman A. M., eds.) Winston, Washington.

    Google Scholar 

  116. Overton D. A. (1977) Comparison of ethanol, pentobarbital and phenobarbetal using drug vs drug discrimination training. Psychopharmacology 53, 195–199.

    PubMed  CAS  Google Scholar 

  117. Overton D. A. (1978) Influence of Training Compartment Design on Performance in the Two-Bar Drug Discrimination Task: A Methodological Report, in Stimulus Properties of Drugs: Ten Years of Progress (Colpaert F. C. and Rosecrans J. A., eds.) Elsevier, Amsterdam.

    Google Scholar 

  118. Overton D. A. (1979a) Influence of shaping procedures and schedules of reinforcement on performance in the two-bar drug discrimination task: A methodological report. Psychopharmacology 65, 291–298.

    PubMed  CAS  Google Scholar 

  119. Overton D. A. (1979b) Drug discrimination training with progressively lowered doses. Science 205, 720–721.

    PubMed  CAS  Google Scholar 

  120. Overton D. A. (1982) Multiple drug training as a method for increasing the specificity of the drug discrimination procedure. J. Pharmacol. Exp. Ther. 221, 166–172.

    PubMed  CAS  Google Scholar 

  121. Overton D. A. (1983) Test for a neurochemically specific mechanism mediating drug discriminations and for stimulus masking. Psychopharmacology 81, 340–344.

    PubMed  CAS  Google Scholar 

  122. Overton D. A. (1984) State Dependent Learning and Drug Discriminations, in Handbook of Psychopharmacology vol. 18 (Iversen L. L., Iversen S. D., and Snyder S. H., eds.) Plenum, New York.

    Google Scholar 

  123. Overton D. A. and Batta S. K. (1977) Relationship Between Abuse Liability of Drugs and Their Degree of Discnminability in the Rat, in Predicting Dependence Liability of Stimulant and Depressant Drugs (Thompson T. and Unna K. R., eds.) University Park, Baltimore.

    Google Scholar 

  124. Overton D. A. and Batta S. K. (1979) Investigation of narcotics and antitussives using drug discrimination techniques. J. Pharmacol. Exp. Ther. 211, 401–408.

    PubMed  CAS  Google Scholar 

  125. Overton D. A., Merkle D. A., and Hayes M. (1983) Are “no drug” cues discriminated during drug-discrimination training? Anim. Learn. Behav. 11, 295–301.

    Google Scholar 

  126. Paule M. G. and Wenger G. R. (1986) Morphine discrimination in the pigeon using a color tracking procedure. Pharmacol. Biochem. Behav. 24, 597–604.

    PubMed  CAS  Google Scholar 

  127. Pellow S. (1985) Can drug effects on anxiety and convulsions be separated? Neurosci. Btobehav. Rev. 9, 55–73.

    CAS  Google Scholar 

  128. Rescorla R. A., Durlach P. J., and Grau J. W. (1984) Contextual Learning in Pavlovian Conditioning, in Context and Learning (Balsam P. D. and Tomie A., eds.) LEA, Hillsdale.

    Google Scholar 

  129. Schechter M. D. (1977) Caffeine potentiation of amphetamine: Implications for hyperkinesis therapy. Pharmacol. Biochem. Behav. 6, 359–361.

    PubMed  CAS  Google Scholar 

  130. Schechter M. D. (1980) Caffeine potentiation of apomorphine discrimination. Pharmacol. Biochem. Behav. 13, 307–309.

    PubMed  CAS  Google Scholar 

  131. Schechter M. D. (1981) Haloperidol-induced supersensitivity to the discrimination of apomorphine. Eur. ]. Pharmacol. 74, 343–346.

    CAS  Google Scholar 

  132. Schechter M. D. (1983a) Drug sensitivity of individual rats determines degree of drug discrimination. Pharmacol. Biochem. Behav. 19, 1–4.

    PubMed  CAS  Google Scholar 

  133. Schechter M. D. (1983b) Behavioral interactions of coadministered amphetamine and pentobarbital. Eur. J. Pharmacol. 86, 447–451.

    PubMed  CAS  Google Scholar 

  134. Schechter M. D. and Concannon J. T. (1984) Differential effects of apomorphine in 6-hydroxydopamine-treated and aged rats. Psychopharmacology 83, 99–103.

    PubMed  CAS  Google Scholar 

  135. Schechter M. D. and Finkelstein J. A. (1985) Effect of dopamine agonists and fenfluramine on discriminative behavior in obese and lean zucker rats. Pharmacol. Biochem. Behav. 23, 7–11.

    PubMed  CAS  Google Scholar 

  136. Schechter M. D. and Lovano D. M. (1982) Time-course action of ethanol upon a stimulant-depressant continuum. Arch. int. Pharmacodyn. Ther. 260, 189–195.

    PubMed  CAS  Google Scholar 

  137. Schechter M. D. and Rosecrans J. A. (1972) Behavioral tolerance to an effect of nicotine in the rat. Arch. int. Pharmacodyn. Ther. 195, 52–56.

    PubMed  CAS  Google Scholar 

  138. Schuster C. R. and Balster R. L. (1977) The Discriminative Stimulus Properties of Drugs, in Advances in Behavioral Pharmacology vol. 1 (Thompson T. and Dews P. B., eds.) Academic, New York.

    Google Scholar 

  139. Sethi B. B., Trivedi J. K., Kumar P., Gulati A., Agarwal A. K., and Sethi N. (1986) Antianxiety effect of cannabis: Involvement of central benzodiazepine receptors. Biol. Psychiatry 21, 3–10.

    PubMed  CAS  Google Scholar 

  140. Shannon H. E. (1983) Discriminative Stimulus Effects of Phencyclidine: Structure-Activity Relationships, in Phencyclidine and Related Arylcyclohexylamines; Present and Future Applications (Kamenka J. M., Domino E. F., and Geneste P., eds.) NPP Books, Ann Arbor.

    Google Scholar 

  141. Shannon H. E. and Holtzman S. G. (1976) Evaluation of the discriminative effects of morphine in the rat. J. Pharmacol. Exp. Ther. 198, 54–65.

    PubMed  CAS  Google Scholar 

  142. Shearman G. T. and Lal H. (1981) Discriminative stimulus properties of cocaine related to an anxiogenic action. Prog. Neuropsychopharmacol. 5, 57–63.

    PubMed  CAS  Google Scholar 

  143. Siegel S. (1983) Classical Conditioning, Drug Tolerance, and Drug Dependence, in Research Advances in Alcohol and Drug Problems, vol. 7 (Smart et al., ed.) Plenum, New York.

    Google Scholar 

  144. Spealman R. D. (1985) Discriminative-stimulus effects of midazolam in squirrel monkeys: Comparison with other drugs and antagonism by Ro 15-1788. J. Pharmacol. Exp. Ther. 225, 456–462.

    Google Scholar 

  145. Stolerman I. P. and D’Mello G. D. (1981) Role of training conditions in discrimination of central nervous system stimulants in rats. Psychopharmacology 73, 295–303.

    PubMed  CAS  Google Scholar 

  146. Stolerman I. P. and Shine P. J. (1985) Trends in drug discrimination research analysed with a cross-indexed bibliography, 1982–1983. Psychopharmacology 86, 1–11.

    PubMed  CAS  Google Scholar 

  147. Stolerman I. P., Baldy R. E., and Shine P. J. (1982) Drug Discrimination Procedure: A Bibliography, in Drug Discrimination Applications in CNS Pharmacology (Colpaert F. C. and Slangen J. L., eds.) Elsevier, Amsterdam.

    Google Scholar 

  148. Swedberg M. D. B. (1985) A model of discrimination learning with interoceptive stimuli. Doctoral dissertation from the Faculty of Social Sciences at the University of Uppsala.

    Google Scholar 

  149. Swedberg M. D. B. and Järbe T. U. C. (1982) Morphine Cue Saliency: Limits of Discriminability and Third-State Perception by Pigeons, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert F. C. and Slangen J. L., eds.) Elsevier, Amsterdam.

    Google Scholar 

  150. Swedberg M. D. B. and Järbe T. U. C. (1985) Drug discrimination procedures: Role of relative stimulus control in two-drug cases. Psychopharmacology 86, 444–451.

    PubMed  CAS  Google Scholar 

  151. Swedberg M. D. B. and Järbe T. U. C. (1986) Drug discrimination procedures: Differential characteristics of the drug A vs drug B and the drug A vs drug B vs no drug case. Psychopharmacology 90, 341–346.

    PubMed  CAS  Google Scholar 

  152. Swedberg M. D. B., Loman P., and Jarbe T. U. C. (1978) Effects of chlormethiazole (Heminevrin®) on drug discrimination and open-field behavior in gerbils. Psychopharmacology 59, 165–170.

    PubMed  CAS  Google Scholar 

  153. Takada K., Winger G., Cook J., Larscheid P., and Woods J. H. (1986) Discriminative and aversive properties of carboline-3-carboxylic acid ethyl ester, a benzodiazepine receptor inverse agonist, in rhesus monkeys. Life Sci. 38, 1049–1056.

    PubMed  CAS  Google Scholar 

  154. Tilson H. A., Baker T. G., and Gylys J. A. (1975) A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylam-phetamine (R-DOM) and S-amphetamine in the rat. Psychopharmacologia 44, 225–228.

    PubMed  CAS  Google Scholar 

  155. Valentino R. J., Herhng S., and Woods J. H. (1983) Discriminative stimulus effects of naltrexone in narcotic-naive and morphine treated pigeons. J. Pharmacol. Exp. Ther. 224, 307–313.

    PubMed  CAS  Google Scholar 

  156. Weissman A. (1976) The discriminability of aspirin in arthritic and non-arthritic rats. Pharmacol. Biochem. Behav. 5, 583–586.

    PubMed  CAS  Google Scholar 

  157. White D. K. and Barrett R. J. (1981) The effects of electroconvulsive shock on the discriminative stimulus properties of d-amphetamine and apomorphine: Evidence for dopamine receptor alteration subsequent to ECS. Psychopharmacology 73, 211–214.

    PubMed  CAS  Google Scholar 

  158. White F. J. and Appel J. B. (1982) Lysergic acid diethylamide (LSD) and lisuride: Differentiation of their neuropharmacological actions. Science 216, 535–537.

    PubMed  CAS  Google Scholar 

  159. White J. M. and Holtzman S. G. (1981) Three-choice drug discrimination in the rat: Morphine, cyclazocme and saline. J. Pharmacol. Exp. Ther. 217, 254–262.

    PubMed  CAS  Google Scholar 

  160. White J. M. and Holtzman S. G. (1983a) Further characterization of the three-choice morphine, cyclazocine and saline discrimination paradigm: opioids with agonist and antagonist properties. J. Pharmacol. Exp. Ther. 224, 95–99.

    PubMed  CAS  Google Scholar 

  161. White J. M. and Holtzman S. G. (1983b) Three-choice drug discrimination: Phencychdine-like stimulus effects of opiates. Psychopharmacology 80, 1–9.

    PubMed  CAS  Google Scholar 

  162. Winter J. C. (1974) Hallucinogens as discriminative stimuli. Fed. Proc. 33, 1825–1832.

    PubMed  CAS  Google Scholar 

  163. Winter J. C. (1978) Drug-Induced Stimulus Control, in: Contemporary Research in Behavioral Pharmacology (Blackman D. E. and Sanger D. J., eds.) Plenum, New York.

    Google Scholar 

  164. Witkin J. M., Dykstra L. A., and Carter R. B. (1982) Acute tolerance to the discriminative stimulus properties of morphine. Pharmacol. Biochem. Behav. 17, 223–228.

    PubMed  CAS  Google Scholar 

  165. Wood D. M., Lal H., and Emmett-Oglesby M. (1984) Acquisition and recovery of tolerance to the discriminative stimulus properties of cocaine. Neuropharmacology 23, 1419–1423.

    PubMed  CAS  Google Scholar 

  166. Woods J. H., Herling S., and Young A. M. (1981) Comparison of discriminative and reinforcing stimulus characteristics of morphine-like opioids and two met-enkephalin analogues. Neuropeptides 1, 409–419.

    CAS  Google Scholar 

  167. Woolverton W. L. and Schuster C. R. (1983) Behavioral and pharmacological aspects of opioid dependence: Mixed agonist-antagonists. Pharmacol. Rev. 35, 33–52.

    PubMed  CAS  Google Scholar 

  168. York J. L. (1981) The ethanol stimulus in rats with differing ethanol preferences. Psychopharmacology 74, 339–343.

    PubMed  CAS  Google Scholar 

  169. Young A. M., Stephens H. R., Hein D. W., and Woods J. H. (1984) Reinforcing and discriminative stimulus properties of mixed agonistantagonist drugs. J. Pharmacol. Exp. Ther. 229, 118–126.

    PubMed  CAS  Google Scholar 

  170. Young A. M., Woods J. H., Herling S., and Hein D. W. (1983) Comparison of the Reinforcing and Discriminative Stimulus Properties of Opioids and Opioid Peptides, in The Neurobiology of Opiate Reward Processes (Smith J. E. and Lane J. D., eds.) Elsevier, Amsterdam.

    Google Scholar 

  171. Zenick H. and Goldsmith M. (1981) Drug discrimination learning in lead-exposed rats. Science 212, 569–571.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, University of Uppsala, Uppsala, Sweden

    Torbjörn U. C. Järbe

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  1. Torbjörn U. C. Järbe
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  1. Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  2. Neurochemical Research Unit, University of Alberta, Edmonton, Canada

    Glen B. Baker  & Andrew J. Greenshaw  & 

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Järbe, T.U.C. (1989). Discrimination Learning with Drug Stimuli. In: Boulton, A.A., Baker, G.B., Greenshaw, A.J. (eds) Psychopharmacology. Neuromethods, vol 13. Humana Press, Totowa, NJ. https://doi.org/10.1385/0-89603-129-2:513

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  • DOI: https://doi.org/10.1385/0-89603-129-2:513

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-129-6

  • Online ISBN: 978-1-59259-618-8

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