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Protein Binding of Psychotropic Drugs

Equilibrium Dialysis and Lipophilicity Correlations

  • Protocol
Analysis of Psychiatric Drugs

Part of the book series: Neuromethods ((NM,volume 10))

Abstract

Binding of drugs to plasma protein has been known for many years to be significant in both drug effects and pharmacokinetics (Goldstein, 1949; Gillette, 1973; Curry, 1980; Meyer and Guttman, 1968; Vallner, 1974). However, in spite of rigorous study, binding remains contentious and poorly understood. This review is concerned with binding phenomena concernmg psychotropic drugs, methods of study, and pharmacological significance. Tissue binding is also considered. Special attention is given to the most popular assessment technique—equilibrium dialysis. This technique has recently undergone rigorous reevaluation.

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Author information

Authors and Affiliations

  1. Division of Clinical Pharmacokinetics, College of Pharmacy, University of Florida, Gainesvzlle, Florida

    Stephen H. Curry

  2. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan

    Oliver Y-P Hu

  3. Department of Pharmacology and Therapeutics, The London Hospital Medical College, London, UK

    Robin Whelpton

Authors
  1. Stephen H. Curry
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  2. Oliver Y-P Hu
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  3. Robin Whelpton
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Editor information

Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  2. University of Alberta, Edmonton, Canada

    Glen B. Baker  & Ronald T. Coutts  & 

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© 1988 The Humana Press Inc.

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Curry, S.H., Hu, O.YP., Whelpton, R. (1988). Protein Binding of Psychotropic Drugs. In: Boulton, A.A., Baker, G.B., Coutts, R.T. (eds) Analysis of Psychiatric Drugs. Neuromethods, vol 10. Humana Press. https://doi.org/10.1385/0-89603-121-7:1

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  • DOI: https://doi.org/10.1385/0-89603-121-7:1

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-121-0

  • Online ISBN: 978-1-59259-615-7

  • eBook Packages: Springer Protocols

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