Immortalization of Human B-Lymphocytes by Epstein-Barr Virus

  • Paul M. Brickell
Part of the Methods in Molecular Biology book series (MIMB, volume 8)


Epstein-Barr virus (EBV) is able to immortalize human B-lymphocytes with high efficiency. This property underlies the role of EBV in a number of human diseases. First, EBV is the causative agent of infectious mononucleosis, which is a benign proliferation of B-lymphocytes (1). Second, EBV is involved in the etiology of Burkitt’s lymphoma (2) and of invasive B-lymphocyte proliferations found in immunosuppressed individuals (3).


Fetal Calf Serum Latent Membrane Protein Infectious Mononucleosis Immunosuppressed Individual Viral Gene Product 
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Copyright information

© The Humana Press Inc., Clifton, NJ 1991

Authors and Affiliations

  • Paul M. Brickell
    • 1
  1. 1.Medical Molecular Biology UnitUniversity College and Middlesex School of MedicineLondonUK

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