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Protein Threading

  • Protocol
The Proteomics Protocols Handbook

Part of the book series: Springer Protocols Handbooks ((SPH))

Abstract

Theoreticians have been trying to predict protein structure based on sequence information for decades. Literally, more than a quarter century ago, there were optimistic reports that one could use simulation methods to calculate the structure of a small protein given only its sequence (xc1|1,2). To this day, devotees of this approach persevere and may ultimately win over the problems with force fields and the enormous search space. In the meantime, a class of protein structure methods have developed, traveling under names such as “protein threading” and “fold recognition.”

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  1. Zentrum fÜr Bioinformatik, University of Hamburg, Hamburg, Germany

    Andrew E. Torda

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  1. University of Hertfordshire, Hatfield, UK

    John M. Walker

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Torda, A.E. (2005). Protein Threading. In: Walker, J.M. (eds) The Proteomics Protocols Handbook. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1385/1-59259-890-0:921

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  • DOI: https://doi.org/10.1385/1-59259-890-0:921

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