Transporter Current Measurements

  • Mami Noda
Part of the Springer Protocols Handbooks book series (SPH)


Na+/K+ pump, Na+/Ca2+ exchanger, glutamate transporter and other transporters for dopamine, norepinephrine, GABA, and others, are all electrogenic. These transporters or exchanger transport Na+ ions, with or without transmitters, in or out of the cells, while K+ or Ca2+, sometimes with anions, are transported to the opposite direction. Since more Na+ is transported, it induces net positive charge movement, therefore producing membrane currents in the direction of Na+ ion movement. Na+/K+ pump can work against ion gradient because it is an ATPase (Na+/K+-ATPase). In addition, under a certain condition, the Na+/K+ pump transforms into an ion channel so that it produces pump-channel currents. Other exchangers and transporters are generally dependent on electrochemical potential gradients and also voltage-dependent.


Cystic Fibrosis Transmembrane Conductance Regulator Glutamate Transporter Exchange Current Transporter Current Pump Current 
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Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Laboratory of Pathophysiology, Graduate School of Pharmaceutical SciencesKyushu UniversityFukuokaJapan

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