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Transporter Current Measurements

  • Mami Noda
Part of the Springer Protocols Handbooks book series (SPH)

Abstract

Na+/K+ pump, Na+/Ca2+ exchanger, glutamate transporter and other transporters for dopamine, norepinephrine, GABA, and others, are all electrogenic. These transporters or exchanger transport Na+ ions, with or without transmitters, in or out of the cells, while K+ or Ca2+, sometimes with anions, are transported to the opposite direction. Since more Na+ is transported, it induces net positive charge movement, therefore producing membrane currents in the direction of Na+ ion movement. Na+/K+ pump can work against ion gradient because it is an ATPase (Na+/K+-ATPase). In addition, under a certain condition, the Na+/K+ pump transforms into an ion channel so that it produces pump-channel currents. Other exchangers and transporters are generally dependent on electrochemical potential gradients and also voltage-dependent.

Keywords

Cystic Fibrosis Transmembrane Conductance Regulator Glutamate Transporter Exchange Current Transporter Current Pump Current 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Laboratory of Pathophysiology, Graduate School of Pharmaceutical SciencesKyushu UniversityFukuokaJapan

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