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Spliceosomal Pre-mRNA Splicing pp 55–82Cite as

Regulation of Alternative Pre-mRNA Splicing

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1126))

Abstract

Alternative splicing plays a prevalent role in generating functionally diversified proteomes from genomes with a more limited repertoire of protein-coding genes. Alternative splicing is frequently regulated with cell type or developmental specificity and in response to signaling pathways, and its mis-regulation can lead to disease. Co-regulated programs of alternative splicing involve interplay between a host of cis-acting transcript features and trans-acting RNA-binding proteins. Here, we review the current state of understanding of the logic and mechanism of regulated alternative splicing and indicate how this understanding can be exploited to manipulate splicing for therapeutic purposes.

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Acknowledgments

Work in the authors’ lab is supported by grants from the Wellcome Trust (092900) and the Biotechnology and Biological Sciences Research Council (BB/H004203/1 and BB/J0014567/1).

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Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge, Cambridge, UK

    Miguel B. Coelho & Christopher W. J. Smith

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  1. Miguel B. Coelho
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  2. Christopher W. J. Smith
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  1. University of California, Irvine, California, USA

    Klemens J. Hertel

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Coelho, M.B., Smith, C.W.J. (2014). Regulation of Alternative Pre-mRNA Splicing. In: Hertel, K. (eds) Spliceosomal Pre-mRNA Splicing. Methods in Molecular Biology, vol 1126. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-980-2_5

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  • DOI: https://doi.org/10.1007/978-1-62703-980-2_5

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-979-6

  • Online ISBN: 978-1-62703-980-2

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