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miRNomics: MicroRNA Biology and Computational Analysis pp 303–310Cite as

Master Regulators of Posttranscriptional Gene Expression Are Subject to Regulation

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1107))

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs of 17–25 nt in length that control gene expression posttranscriptionally. As master regulators of posttranscriptional gene expression, miRNAs themselves are subject to tight regulation at multiple steps. The most common mechanisms include miRNA transcription, processing, and localization. Additionally, intricate feedback loops between miRNAs and transcription factors result in unidirectional, reciprocal, or self-directed elegant control mechanisms. In this chapter, we focus on the posttranscriptional regulatory mechanisms that generate miRNAs whose sequence might be slightly different from the miRNA-coding sequences. Hopefully, this information will be helpful in the discovery of novel miRNAs as well as in the analysis of deep-sequencing data and ab initio prediction of miRNAs.

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Acknowledgement

This work was supported by the Scientific and Technical Research Council of Turkey (104T144, 107T475, and 210T006 to BA).

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Authors and Affiliations

  1. Molecular Biology and Genetics, Izmir Institute of Technology, Izmir, Turkey

    Syed Muhammad Hamid & Bünyamin Akgül

Authors
  1. Syed Muhammad Hamid
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  2. Bünyamin Akgül
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Editor information

Editors and Affiliations

  1. Dabburiya Village, Israel

    Malik Yousef

  2. Izmir Institute of Technology, Izmir, Turkey

    Jens Allmer

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Hamid, S.M., Akgül, B. (2014). Master Regulators of Posttranscriptional Gene Expression Are Subject to Regulation. In: Yousef, M., Allmer, J. (eds) miRNomics: MicroRNA Biology and Computational Analysis. Methods in Molecular Biology, vol 1107. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-748-8_18

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  • DOI: https://doi.org/10.1007/978-1-62703-748-8_18

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-747-1

  • Online ISBN: 978-1-62703-748-8

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