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Structural Genomics pp 315–331Cite as

Navigating the Global Protein–Protein Interaction Landscape Using iRefWeb

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1091))

Abstract

iRefWeb is a bioinformatics resource that offers access to a large collection of data on protein–protein interactions in over a thousand organisms. This collection is consolidated from 14 major public databases that curate the scientific literature. The collection is enhanced with a range of versatile data filters and search options that categorize various types of protein–protein interactions and protein complexes. Users of iRefWeb are able to retrieve all curated interactions for a given organism or those involving a given protein (or a list of proteins), narrow down their search results based on different supporting evidence, and assess the reliability of these interactions using various criteria. They may also examine all data and annotations related to any publication that described the interaction-detection experiments. iRefWeb is freely available to the research community worldwide at http://wodaklab.org/iRefWeb.

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Acknowledgements

This work was supported by the Canadian Institutes of Health Research (MOP#82940), the Ontario Research Fund, and the SickKids Foundation. SJW was Canada Research Chair, Tier 1.

Author information

Authors and Affiliations

  1. Molecular Structure and Function program, Hospital for Sick Children, Toronto, ON, Canada

    Andrei L. Turinsky, Brian Turner & Shoshana J. Wodak

  2. The Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway

    Sabry Razick & Ian M. Donaldson

  3. Biomedical Research Group, Department of Informatics, University of Oslo, Oslo, Norway

    Sabry Razick

  4. Department of Molecular Biosciences, University of Oslo, Oslo, Norway

    Ian M. Donaldson

  5. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

    Shoshana J. Wodak

  6. Department of Biochemistry, University of Toronto, Toronto, ON, Canada

    Shoshana J. Wodak

Authors
  1. Andrei L. Turinsky
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  2. Sabry Razick
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  4. Ian M. Donaldson
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  5. Shoshana J. Wodak
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Editor information

Editors and Affiliations

  1. King's College London, London, United Kingdom

    Yu Wai Chen

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Turinsky, A.L., Razick, S., Turner, B., Donaldson, I.M., Wodak, S.J. (2014). Navigating the Global Protein–Protein Interaction Landscape Using iRefWeb. In: Chen, Y. (eds) Structural Genomics. Methods in Molecular Biology, vol 1091. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-691-7_22

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  • DOI: https://doi.org/10.1007/978-1-62703-691-7_22

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-690-0

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