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Lentiviral Vectors in Huntington’s Disease Research and Therapy

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Viral Vector Approaches in Neurobiology and Brain Diseases

Part of the book series: Neuromethods ((NM,volume 82))

Abstract

We describe here the potential of viral-mediated gene transfer for the modeling and treatment of Huntington’s disease, focusing in particular on strategies for the tissue-specific targeting of various CNS cells. The protocols described here cover the design of lentiviral vectors, strategies for modifying their tropism, including the use of various envelopes and tissue-specific promoters, and the potential of miRNA to regulate transgene expression.

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Authors and Affiliations

  1. Atomic Energy Commission (CEA), Institute of Biomedical Imaging (I2BM), and Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France

    Aurélie Delzor, Noëlle Dufour & Nicole Déglon

  2. Laboratory of Cellular and Molecular Neurotherapies (LCMN), Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), Lausanne, Switzerland

    Nicole Déglon

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  1. Aurélie Delzor
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  2. Noëlle Dufour
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  3. Nicole Déglon
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Editors and Affiliations

  1. Institute of Experimental Neurology, San Raffaele Scientific Institute Division of Neuroscience, Milan, Italy

    Riccardo Brambilla

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Delzor, A., Dufour, N., Déglon, N. (2014). Lentiviral Vectors in Huntington’s Disease Research and Therapy. In: Brambilla, R. (eds) Viral Vector Approaches in Neurobiology and Brain Diseases. Neuromethods, vol 82. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-610-8_11

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  • DOI: https://doi.org/10.1007/978-1-62703-610-8_11

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