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The Use of Calorie Restriction Mimetics to Study Aging

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Biological Aging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1048))

Abstract

Calorie restriction (CR) has a variety of effects on extending lifespan and delaying the onset of age-related diseases, and it is accepted as the only established experimental antiaging intervention. Several pharmacological agents that can replicate the beneficial effects of CR, called calorie restriction mimetics (CRMs), have been identified. The nutrient-sensing pathways including those involving sirtuins (especially SIRT1) and mammalian target of rapamycin (mTOR) may regulate the physiology of CR, and candidate CRMs that modulate these specific pathways have been identified and investigated using animal models. In this chapter, we focus on candidate CRMs including sirtuin-activating compounds (STACs) and mTOR inhibitors, their slowing of aging, and methods for evaluation of lifespan and metabolic disorders.

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Acknowledgements

This work was supported by a Grant from Novo Nordisk Pharma, a Grant-in-Aid for Scientific Research (C) (24591218), and a Grant for Promoted Research from Kanazawa Medical University (S2012-4) to M. Kitada and by Grants for Collaborative Research (C2012-1) and Specially Promoted Research from Kanazawa Medical University (SR2012-06) and the Fourth Annual Research Award Grant of Japanese Society of Anti-Aging Medicine to D. Koya.

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Authors and Affiliations

  1. Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan

    Munehiro Kitada & Daisuke Koya

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  1. Munehiro Kitada
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  2. Daisuke Koya
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Editors and Affiliations

  1. Dept. Biology, University of Alabama, Birmingham Dept. Biology, Birmingham, Alabama, USA

    Trygve O. Tollefsbol

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Kitada, M., Koya, D. (2013). The Use of Calorie Restriction Mimetics to Study Aging. In: Tollefsbol, T. (eds) Biological Aging. Methods in Molecular Biology, vol 1048. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-556-9_8

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  • DOI: https://doi.org/10.1007/978-1-62703-556-9_8

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-555-2

  • Online ISBN: 978-1-62703-556-9

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