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Angiogenic Nanodelivery Systems for Myocardial Therapy

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Book cover Cellular Cardiomyoplasty

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1036))

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Abstract

Despite outstanding progress in the area of cardiovascular diseases, significant challenges remain in designing efficient delivery systems for myocardial therapy. Nanotechnology provides the tools to explore such frontiers of biomedical science at cellular level and thus offers unique features for potential application in the field of cardiac therapy. This chapter focuses on the methodology, based on the work done in our lab, to prepare and investigate two kinds of biocompatible nanoparticles (NPs) that can be useful for sustained delivery of single or multiple angiogenic growth factors to damaged sites, such as in myocardially infarcted heart to promote myocardial angiogenesis and reduce scar area.

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Acknowledgments

This work is supported in part by research grant from Canadian Institutes of Health Research and Natural Sciences and Engineering Research Council, Canada. A. Paul acknowledges postdoctoral award from Fonds Québécois de la Recherche sur la Nature et les Technologies (FRSQ, Canada).

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Authors and Affiliations

  1. Department of Biomedical Engineering, Biomedical Technology and Cell Therapy Research Laboratory, Artificial Cells and Organs Research Centre, McGill University, Montreal, QC, Canada

    Arghya Paul & Satya Prakash

  2. Department of Surgery, Division of Cardiac Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada

    Dominique Shum-Tim

  3. Department of Surgery, Division of Surgical Research, McGill University Health Center, McGill University, Montreal, QC, Canada

    Dominique Shum-Tim

Authors
  1. Arghya Paul
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  2. Dominique Shum-Tim
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  3. Satya Prakash
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Editor information

Editors and Affiliations

  1. , Department of Surgery, East Tennessee State University, Johnson City, 37614, Tennessee, USA

    Race L. Kao

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Paul, A., Shum-Tim, D., Prakash, S. (2013). Angiogenic Nanodelivery Systems for Myocardial Therapy. In: Kao, R. (eds) Cellular Cardiomyoplasty. Methods in Molecular Biology, vol 1036. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-511-8_12

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  • DOI: https://doi.org/10.1007/978-1-62703-511-8_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-510-1

  • Online ISBN: 978-1-62703-511-8

  • eBook Packages: Springer Protocols

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