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Targeting Wnt Signaling to Improve Wound Healing After Myocardial Infarction

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Book cover Wound Regeneration and Repair

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1037))

Abstract

Myocardial infarction is one of the major causes of left ventricular dilatation, frequently leading to heart failure. In the last decade, the wound healing process that takes place in the infarct area after infarction has been recognized as a novel therapeutic target to attenuate left ventricular dilatation and preserve an adequate cardiac function. In this chapter, we discuss the role of Wnt signaling in the wound healing process after infarction, with a specific focus on its modulating effect on myofibroblast characteristics.

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Acknowledgments

The financial support for this research line by the Department of Economic Affairs of The Netherlands (BSIK grant 03033) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Pharmacology, CARIM, Maastricht University, Maastricht, The Netherlands

    Evangelos P. Daskalopoulos, Ben J. A. Janssen & W. Matthijs Blankesteijn

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  1. Evangelos P. Daskalopoulos
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  2. Ben J. A. Janssen
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  3. W. Matthijs Blankesteijn
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Editors and Affiliations

  1. Virginia Tech Carilion Research Institut, Roanoke, Virginia, USA

    Robert G. Gourdie

  2. School of Pharmacy, MCPHS University, Worcester, Massachusetts, USA

    Tereance A. Myers

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Daskalopoulos, E.P., Janssen, B.J.A., Blankesteijn, W.M. (2013). Targeting Wnt Signaling to Improve Wound Healing After Myocardial Infarction. In: Gourdie, R., Myers, T. (eds) Wound Regeneration and Repair. Methods in Molecular Biology, vol 1037. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-505-7_21

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  • DOI: https://doi.org/10.1007/978-1-62703-505-7_21

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  • Print ISBN: 978-1-62703-504-0

  • Online ISBN: 978-1-62703-505-7

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