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Wound Regeneration and Repair pp 299–311Cite as

A Novel and Efficient Model of Coronary Artery Ligation in the Mouse

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1037))

Abstract

Coronary artery ligation to induce myocardial infarction (MI) and ischemia/reperfusion (I/R) injury in mice is typically performed by an invasive and time-consuming approach that requires ventilation and a full thoracotomy (classical method), often resulting in extensive tissue damage and high mortality. Here, we describe a novel and rapid surgical method to induce MI that does not require ventilation. This method is much more efficient and safer than the classical method of MI and I/R injury.

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Author information

Authors and Affiliations

  1. Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA

    Erhe Gao & Walter J. Koch

Authors
  1. Erhe Gao
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  2. Walter J. Koch
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Editor information

Editors and Affiliations

  1. Virginia Tech Carilion Research Institut, Roanoke, Virginia, USA

    Robert G. Gourdie

  2. School of Pharmacy, MCPHS University, Worcester, Massachusetts, USA

    Tereance A. Myers

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Gao, E., Koch, W.J. (2013). A Novel and Efficient Model of Coronary Artery Ligation in the Mouse. In: Gourdie, R., Myers, T. (eds) Wound Regeneration and Repair. Methods in Molecular Biology, vol 1037. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-505-7_17

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  • DOI: https://doi.org/10.1007/978-1-62703-505-7_17

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-504-0

  • Online ISBN: 978-1-62703-505-7

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