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A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma

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Mouse Models of Allergic Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1032))

Abstract

Airway remodeling is a term used to collectively indicate bronchial structural changes that may lead to irreversible airflow obstruction and progressive decline in lung function in asthmatic patients. Bronchial myofibroblasts contribute to airway remodeling by producing collagenous proteins in the subepithelial zone and by increasing the density of contractile cells in the bronchial wall. A substantial proportion of bronchial myofibroblasts in asthma differentiate from circulating mesenchymal progenitor cells known as fibrocytes. Here, we describe a mouse model of allergic asthma for evaluating the functional role of fibrocytes and myofibroblasts in this disease and the inhibitory effects of novel therapeutic candidates.

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Author information

Authors and Affiliations

  1. Avail Biomedical Research Institute, Basel, Switzerland

    Matthias Schmidt & Sabrina Mattoli

Authors
  1. Matthias Schmidt
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  2. Sabrina Mattoli
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Editor information

Editors and Affiliations

  1. Dept. of Biomedical Sciences & Pathobiol, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

    Irving C. Allen

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Schmidt, M., Mattoli, S. (2013). A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma. In: Allen, I. (eds) Mouse Models of Allergic Disease. Methods in Molecular Biology, vol 1032. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-496-8_19

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  • DOI: https://doi.org/10.1007/978-1-62703-496-8_19

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-495-1

  • Online ISBN: 978-1-62703-496-8

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