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Dextran Sodium Sulfate-Induced Murine Inflammatory Colitis Model

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Mouse Models of Innate Immunity

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1031))

Abstract

Colitis is a chronic inflammatory disease of the colon that is characterized by recurring, acute episodes. Mouse models of colitis allow for the study of multiple aspects of this disease, including the innate immune response, epithelial and intestinal cell response, and wound healing. The following protocols cover acute, chronic, and cancer-associated colitis models.

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References

  1. Lakatos P-L (2006) Recent trends in the epidemiology of inflammatory bowel diseases: up or down? World J Gastroenterol 12(38):6102–6108

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  2. 1999–2007 Cancer Incidence and Mortality Data. Center for Disease Control and Prevention. http://apps.nccd.cdc.gov/uscs/. Downloaded 12/14/2012

  3. Terzić J, Grivennikov S, Karin E, Karin M (2010) Inflammation and colon cancer. Gastroenterology 138(6):2101.e5–2114.e5

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Schneider, M. (2013). Dextran Sodium Sulfate-Induced Murine Inflammatory Colitis Model. In: Allen, I. (eds) Mouse Models of Innate Immunity. Methods in Molecular Biology, vol 1031. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-481-4_21

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  • DOI: https://doi.org/10.1007/978-1-62703-481-4_21

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-480-7

  • Online ISBN: 978-1-62703-481-4

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