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Platelet Physiology

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Haemostasis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 992))

Abstract

Platelets are cell fragments which circulate in blood. They are of pivotal importance in blood clot formation, affecting thrombosis and haemostasis. By rapidly altering the activation and expression of surface receptors, platelets are able to quickly undergo structural and phenotypic changes in response to stimulation, such as collagen exposure on injured vascular endothelium. This response to stimulation allows platelets to become adhesive, aggregate to form a thrombus, and release a variety of mediators affecting coagulation, inflammation, and chemotaxis at the site of injury. Therefore, in addition to their critical role in thrombosis and haemostasis, platelets also play a role in immunity, inflammation, wound healing, haematologic malignancies, and metabolic disorders. The role of platelets in disease, particularly in atherothrombosis, is increasingly the focus of current research and antiplatelet therapy plays a significant role in the prevention and treatment of atherothrombotic and inflammatory diseases.

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  1. Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, WA, Australia

    Matthew D. Linden

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  1. Department of Paediatrics, University of Melbourne, n/a, Parkville, 3052, Victoria, Australia

    Paul Monagle

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Linden, M.D. (2013). Platelet Physiology. In: Monagle, P. (eds) Haemostasis. Methods in Molecular Biology, vol 992. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-339-8_2

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  • DOI: https://doi.org/10.1007/978-1-62703-339-8_2

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