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Photoreceptor Degeneration in Mice: Adeno-Associated Viral Vector-Mediated Delivery of Erythropoietin

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Tissue-Protective Cytokines

Part of the book series: Methods in Molecular Biology ((MIMB,volume 982))

Abstract

The exogenous delivery of erythropoietin (EPO) and EPO derivatives (EPO-Ds) represents a valuable strategy to protect the retina from degeneration. In this chapter we describe a method to deliver EPO and the EPO derivative S100E in the light-damage model of induced retinal degeneration using adeno-­associated viral (AAV) vectors and to evaluate the functional and morphological protection of the retina from light damage.

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Author information

Authors and Affiliations

  1. Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

    Pasqualina Colella & Alberto Auricchio

  2. Medical Genetics, Department of Medical Translational Science, Federico II University, Naples, Italy

    Alberto Auricchio

Authors
  1. Pasqualina Colella
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  2. Alberto Auricchio
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Editor information

Editors and Affiliations

  1. Medical School, Brighton and Sussex, Trafford Centre, Falmer, BN1 9RY, United Kingdom

    Pietro Ghezzi

  2. Leiden University Medical Center, Stille Rijn 11a, Leiden, 2312 DE, Netherlands

    Anthony Cerami

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Colella, P., Auricchio, A. (2013). Photoreceptor Degeneration in Mice: Adeno-Associated Viral Vector-Mediated Delivery of Erythropoietin. In: Ghezzi, P., Cerami, A. (eds) Tissue-Protective Cytokines. Methods in Molecular Biology, vol 982. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-308-4_16

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  • DOI: https://doi.org/10.1007/978-1-62703-308-4_16

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-307-7

  • Online ISBN: 978-1-62703-308-4

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